ACS Catalysis, Год журнала: 2024, Номер 14(11), С. 8176 - 8183

Опубликована: Май 10, 2024

Axially chiral bridged biaryls represent an important subset of axially biaryl scaffolds in fields ranging from organic synthesis to biochemistry materials science. While numerous catalytic strategies have been elucidated for the construction axial chirality, enantioenriched form remains underdeveloped. Herein, we demonstrate approach synthesize diverse through nickel-catalyzed kinetic asymmetric cleavage unactivated aromatic C–O bond. The system features mild reaction conditions, high resolution efficiency, and versatile post-functionalizations. Mechanistic studies reveal impact nickel catalyst's chirality on stereochemical output this transformation.

Язык: Английский