Axially Chiral Bridged Biaryls by Ni-Catalyzed Kinetic Asymmetric C–O Bond Cleavage

ACS Catalysis, Год журнала: 2024, Номер 14(11), С. 8176 - 8183

Опубликована: Май 10, 2024

Axially chiral bridged biaryls represent an important subset of axially biaryl scaffolds in fields ranging from organic synthesis to biochemistry materials science. While numerous catalytic strategies have been elucidated for the construction axial chirality, enantioenriched form remains underdeveloped. Herein, we demonstrate approach synthesize diverse through nickel-catalyzed kinetic asymmetric cleavage unactivated aromatic C–O bond. The system features mild reaction conditions, high resolution efficiency, and versatile post-functionalizations. Mechanistic studies reveal impact nickel catalyst's chirality on stereochemical output this transformation.

Язык: Английский

Modular Assembly of Axially Chiral QUINAP Derivatives via Nickel-Catalyzed Enantioselective C–P Cross-Coupling

ACS Catalysis, Год журнала: 2025, Номер unknown, С. 8268 - 8273

Опубликована: Май 2, 2025

Язык: Английский

nBu4NBr-Catalyzed Esterification of Methoxyarenes with Acyl Bro-mide

Organic & Biomolecular Chemistry, Год журнала: 2025, Номер unknown

Опубликована: Янв. 1, 2025

The catalytic esterification of methoxyarenes remains challenging, especially for C(sp3)-O bond functionalization. Herein, we report a simple and efficient method using nBu4NBr as catalyst to directly convert acyl bromides into esters under solvent-free conditions. This strategy provides approach, achieving yields up 95%.

Язык: Английский