Catalytic Asymmetric Synthesis of β-Amino α-Tertiary Alcohol through Borrowing Hydrogen Amination
Organic Letters,
Год журнала:
2025,
Номер
unknown
Опубликована: Март 6, 2025
The
first
enantioconvergent
transition-metal-catalyzed
amination
of
racemic
α-tertiary
1,2-diols
providing
access
to
vicinal
β-amino
alcohols
is
disclosed.
iridium-catalyzed
reaction
proceeds
through
a
chiral
phosphoric
acid-mediated
borrowing
hydrogen
pathway
with
excellent
yields
and
enantioselectivities
for
range
amine
nucleophiles
1,2-diols.
An
array
were
obtained
high
(50
examples
up
91%
yield
99%
ee).
These
important
amino
alcohol
products
can
be
easily
converted
into
ligands
bioactive
skeletons.
Mechanistic
investigations
proposed
dynamic
kinetic
resolution
involving
imine
formation
then
reduction
as
the
enantiodetermining
step.
Язык: Английский
Linker engineering of ternary donor–acceptor photosensitizers in chem-stable metal–organic frameworks for efficient photo-catalytic aerobic oxidation
Chemical Engineering Journal,
Год журнала:
2025,
Номер
unknown, С. 163233 - 163233
Опубликована: Апрель 1, 2025
Язык: Английский
Organophotocatalyzed C‐Si Bond Fragmentation Using Silyl Ethers as Radical Precursors
Advanced Synthesis & Catalysis,
Год журнала:
2024,
Номер
366(19), С. 4132 - 4138
Опубликована: Июль 19, 2024
Abstract
In
this
work,
silyl
ethers
of
phenols
and
alcohols
have
been
successfully
prepared
tested
as
neutral
carbon
(silicon)
centered
radical
precursors.
The
organophotocatalyzed
oxidation
(by
the
Fukuzumi
catalyst)
these
caused
cleavage
a
C−Si
(or
Si−Si)
bond
for
release
desired
to
be
used
forging
C(
sp
3
)
−C(
−Si)
bonds
via
Giese
reaction.
Язык: Английский
Unsaturated organosilanes: synthesis, transformations and applications
Russian Chemical Reviews,
Год журнала:
2024,
Номер
93(11), С. RCR5140 - RCR5140
Опубликована: Окт. 30, 2024
The
urgency
of
improving
the
efficiency
known
methods
and
developing
new
ones
for
synthesis
unsaturated
silanes
is
caused
by
need
to
obtain
useful
compounds,
including
biologically
active
ones,
on
their
basis.
This
review
considers
preparation
silanes,
transformations
prospects
use
as
precursors
in
organic
organoelement
synthesis.
A
large
number
substituted
organosilicon
products
are
given,
those
capable
further
functionalization
formation
heterocycles,
silaheterocycles.<br>
bibliography
includes
205
references.
Язык: Английский
Dual N-Heterocyclic Carbene/Photoredox-Catalyzed Coupling of Acyl Fluorides and Alkyl Silanes
ACS Catalysis,
Год журнала:
2024,
Номер
unknown, С. 17642 - 17653
Опубликована: Ноя. 15, 2024
The
combination
of
N-heterocyclic
carbene
(NHC)
organocatalysis
with
photochemical
activation
is
becoming
increasingly
established
as
an
approach
for
conducting
radical
organic
reactions
under
mild
and
practical
conditions.
As
comparatively
easy
to
prepare
handle
compounds,
alkyl
silanes
are
attractive
substrates
chemistry
desilylative
mesolysis
the
corresponding
cations
known
be
rapid.
Here,
we
report
successful
application
benzyl
silane
derivatives
source
radicals
in
dual
NHC/photoredox-catalyzed
radical–radical
coupling
acyl
fluorides.
Relatively
electron-rich
reacted
smoothly
afford
ketones
generally
good
yields,
while
optimization
NHC
photocatalyst
allowed
a
wider
scope
including
primary
substrates.
Furthermore,
initial
experiments
revealed
that
organosilanes
bearing
N-,
O-
S-heteroatoms
can
also
serve
sources
these
Язык: Английский