Dynamic kinetic resolution and dynamic kinetic asymmetric transformation of atropisomeric biaryls
Chem Catalysis,
Год журнала:
2025,
Номер
unknown, С. 101329 - 101329
Опубликована: Март 1, 2025
Язык: Английский
Formal Synthesis of Fostriecin via Asymmetric Alcohol-Mediated Carbonyl Allylation
Organic Letters,
Год журнала:
2025,
Номер
unknown
Опубликована: Апрель 10, 2025
A
formal
synthesis
of
fostriecin
via
convergent
assembly
two
fragments
prepared
asymmetric
alcohol-mediated
C-C
coupling
is
described.
One
fragment
made
by
the
enantioselective
iridium-catalyzed
allylation
an
allylic
alcohol
mediated
allyl
acetate.
The
other
ruthenium-catalyzed
reductive
syn-(α-alkoxy)allylation
aldehyde
alkoxyallene
(where
2-propanol
hydrogen
source),
representing
first
use
this
method
in
target-oriented
synthesis.
Metathetic
union
enables
interception
a
late-stage
compound
that
previously
required
25
step
(LLS)
only
7
steps
(LLS).
Язык: Английский
Asymmetric Vicinal and Remote Hydroamination of Olefins by Employing a Heck-Reaction-Derived Hydride Source
Journal of the American Chemical Society,
Год журнала:
2025,
Номер
unknown
Опубликована: Май 6, 2025
Metal
hydrides
are
reactive
intermediates
in
numerous
catalytic
processes.
In
many
processes,
metal
formed,
but
their
potential
reactivity
is
often
wasted
by
reaction
with
a
base
or
an
oxidant
to
permit
catalyst
turnover.
this
report,
the
hydroamination
of
unactivated
olefins
described
coupling
Heck
between
aryl
boronic
acid,
olefin,
and
nitrene
precursor
dioxazolone.
Initiated
olefin
arylboroic
rhodium
hydride
intermediate
generated
retained
for
second
equivalent
olefin.
Depending
on
chain
length
alkyl
group
α-
β-amino
amides
were
obtained
excellent
regio-
enantioselectivity
via
direct
remote
(migratory)
hydroamination,
respectively.
The
system
features
broad
scope,
mild
conditions,
enantioselectivity,
it
also
represents
rare
example
asymmetric
using
chiral
rhodium(III)
cyclopentadienyl
catalyst.
Mechanistic
studies
delineated
turnover-limiting
enantio-determining
steps
system.
Язык: Английский
Terpenylation of Ketones and a Secondary Alcohol under Hydrogen-Borrowing Manganese Catalysis
The Journal of Organic Chemistry,
Год журнала:
2024,
Номер
unknown
Опубликована: Дек. 16, 2024
An
Earth-abundant
Mn-PNP
pincer
complex-catalyzed
terpenylation
of
cyclic
and
acyclic
ketones
secondary
alcohol
1-phenylethanol
using
isoprenoid
derivatives
prenol,
nerol,
phytol,
solanesol,
E-farnesol
as
allyl
surrogates
is
reported.
The
C-C
coupling
reactions
are
green
atom-economic,
proceeding
via
dehydrogenation
alcohols
following
a
hydrogen
autotransfer
methodology
aided
by
metal-ligand
cooperation.
Язык: Английский