Organic Letters, Год журнала: 2024, Номер 26(43), С. 9288 - 9293

Опубликована: Окт. 21, 2024

A highly regioselective cobalt-catalyzed three-component alkyl arylation of acrylates with iodides and aryl Grignard reagents has been established. The reaction efficiently provides an alternative strategy for the construction α-aryl esters a broad substrate scope good yields under mild conditions. practical applicability this protocol is shown by scaled-up further transformations products. In addition, preliminary mechanistic explorations demonstrated that radicals generated efficient cobalt catalysis are instantaneously added to finally afford desired

Язык: Английский