Preparation of Erlotinib hydrochloride nanoparticles (anti-cancer drug) by RESS-C method and investigating the effective parameters

Scientific Reports, Год журнала: 2024, Номер 14(1)

Опубликована: Июнь 28, 2024

The size of the drug particles is one essential factors for proper absorption compared to dose drug. When particle decreased, uptake into body increases. Recent studies have revealed that rapid expansion supercritical solution with cosolvent plays a significant role in preparing micron and submicron particles. This paper examines preparation Erlotinib hydrochloride nanoparticles using through method first time. An examination parameters temperature (318-338 K), pressures (15-25 MPa) nozzle diameter (300-700 μm) was investigated by Box-Behnken design, their respective effects on has more impact than other parameters. smallest were produced at 338 K, pressure 20 MPa, 700 μm. Besides, ERL characterized SEM, DLS, XRD, FTIR, DSC analyses. Finally, results showed average decreased from 31.6 μm 200-1100 nm.

Язык: Английский

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1 Crystallization of neomycin nanoparticles in the presence of polyvinyl pyrrolidone (PVP)

Nanoscale Advances, Год журнала: 2025, Номер unknown

Опубликована: Янв. 1, 2025

Neomycin nanoparticles were prepared using the inductive crystallization method in presence of polyvinylpyrrolidone (PVP) as a stabilizer.

Язык: Английский

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Antisolvent Crystallization for the Size Reduction of Cholecalciferol: Parametric and Optimization Study

Crystal Research and Technology, Год журнала: 2025, Номер unknown

Опубликована: Март 17, 2025

Abstract The active form of vitamin D 3 , cholecalciferol, is one the essential constituents that allows most cells to develop and differentiate, also critical for parathyroid regulation immune system improvement. Reducing size cholecalciferol can offer several benefits, such as improved surface area, enhanced biological activity, better penetrating power. In this context, antisolvent crystallization utilized decrease particle cholecalciferol. solvent selections are made using Hansen solubility parameters (HSP). effect various factors like ratio (1:1–20:1, v/v), rate addition (5–40, mL h −1 ), stirring speed (200–500 rpm), concentration (2.5–15, mg temperature (15–30 °C) assessed parametric study. individual interaction effects studied central composite design (CCD) followed by model formulation optimization. lowest (111.6 nm) obtained at 2.5 25 addition, 10:1 (v/v) ratio, 20 °C temperature, 300 rpm.

Язык: Английский

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Trends and Advances in Liposome Formulation Technology with an Emphasis on Ensuring Safety and Quality in Food and Drug Applications

Food Bioscience, Год журнала: 2025, Номер unknown, С. 106913 - 106913

Опубликована: Май 1, 2025

Язык: Английский

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