Solvent Minimized Synthesis of Amides by Reactive Extrusion DOI Creative Commons
Robert R. A. Bolt, Harry R. Smallman, Jamie A. Leitch

и другие.

Angewandte Chemie International Edition, Год журнала: 2024, Номер unknown

Опубликована: Сен. 9, 2024

Abstract Herein, we report on the translation of a small scale ball‐milled amidation protocol into large continuous reactive extrusion process. Critical components to successful were: a) understanding how different operating parameters twin‐screw extruder should be harnessed control prolonged operation, and b) consideration physical form input materials. The reaction is applied 36 amides spanning variety combinations (liquid‐liquid, solid–liquid solid‐solid). Following this learning process, have developed an for each combination demonstrated 7‐hour process synthesis amide 500 gram (1.3 mols product).

Язык: Английский

Ball milling for mechanochemical reactions DOI
Isaiah R. Speight, Karen J. Ardila‐Fierro, José G. Hernández

и другие.

Nature Reviews Methods Primers, Год журнала: 2025, Номер 5(1)

Опубликована: Май 22, 2025

Язык: Английский

Процитировано

0
Solvent Minimized Synthesis of Amides by Reactive Extrusion DOI Creative Commons
Robert R. A. Bolt, Harry R. Smallman, Jamie A. Leitch

и другие.

Angewandte Chemie, Год журнала: 2024, Номер unknown

Опубликована: Сен. 9, 2024

Abstract Herein, we report on the translation of a small scale ball‐milled amidation protocol into large continuous reactive extrusion process. Critical components to successful were: a) understanding how different operating parameters twin‐screw extruder should be harnessed control prolonged operation, and b) consideration physical form input materials. The reaction is applied 36 amides spanning variety combinations (liquid‐liquid, solid–liquid solid‐solid). Following this learning process, have developed an for each combination demonstrated 7‐hour process synthesis amide 500 gram (1.3 mols product).

Язык: Английский

Процитировано

0
Solvent Minimized Synthesis of Amides by Reactive Extrusion DOI Creative Commons
Robert R. A. Bolt, Harry R. Smallman, Jamie A. Leitch

и другие.

Angewandte Chemie International Edition, Год журнала: 2024, Номер unknown

Опубликована: Сен. 9, 2024

Abstract Herein, we report on the translation of a small scale ball‐milled amidation protocol into large continuous reactive extrusion process. Critical components to successful were: a) understanding how different operating parameters twin‐screw extruder should be harnessed control prolonged operation, and b) consideration physical form input materials. The reaction is applied 36 amides spanning variety combinations (liquid‐liquid, solid–liquid solid‐solid). Following this learning process, have developed an for each combination demonstrated 7‐hour process synthesis amide 500 gram (1.3 mols product).

Язык: Английский

Процитировано

0