Angewandte Chemie,
Год журнала:
2017,
Номер
130(3), С. 752 - 756
Опубликована: Ноя. 8, 2017
Abstract
A
photoinduced
cascade
strategy
leading
to
a
variety
of
differentially
functionalised
nitriles
and
ketones
has
been
developed.
These
reactions
rely
on
the
oxidative
generation
iminyl
radicals
from
simple
oximes.
Radical
transposition
by
C(sp
3
)−(sp
)
)−H
bond
cleavage
gives
access
distal
carbon
that
undergo
S
H
2
functionalisations.
mild,
visible‐light‐mediated
procedures
can
be
used
for
remote
fluorination,
chlorination,
azidation,
were
applied
modification
bioactive
structurally
complex
molecules.
Organic Letters,
Год журнала:
2018,
Номер
20(15), С. 4614 - 4617
Опубликована: Июль 19, 2018
An
iron-catalyzed
redox-neutral,
decarboxylative
olefination
of
cycloketone
oxime
esters
with
α,β-unsaturated
carboxylic
acids
has
been
developed.
This
reaction
involves
an
iminyl
radical
mediated
C–C
bond
cleavage/radical
addition/decarboxylation
cascade.
protocol
is
highlighted
by
its
low-cost
catalytic
system
and
readily
accessible
starting
materials,
as
well
broad
substrate
scope,
thus
providing
facile
access
to
structurally
diverse
cyano-containing
alkenes.
Organic Letters,
Год журнала:
2019,
Номер
21(8), С. 2723 - 2730
Опубликована: Март 29, 2019
By
merging
C–F
and
C–C
bond
activation
in
the
cross-electrophile
coupling,
we
developed
an
efficient
cyanide-free
synthesis
of
diverse
functional-group-rich
cyano-substituted
gem-difluoroalkenes
using
cyclobutanone
oxime
esters
trifluoromethyl
alkenes
as
precursors.
Notably,
this
Ni-catalyzed
reaction
is
bestowed
with
broad
substrate
scope,
low
catalyst
loading,
complete
regioselectivities,
high
tolerance
a
wide
range
sensitive
functional
groups.
Preliminary
mechanistic
studies
indicate
that
iminyl
radical-initiated
cleavage
involved
pathway.
The Journal of Organic Chemistry,
Год журнала:
2017,
Номер
83(2), С. 1046 - 1055
Опубликована: Дек. 14, 2017
The
copper-catalyzed
cyclization
of
activated
alkenes
with
cyclobutanone
O-acyl
oximes
under
redox-neutral
conditions
has
been
reported.
This
facile
protocol
provided
an
efficient
approach
to
a
variety
cyanoalkylated
oxindoles
and
dihydroquinolin-2(1H)-ones
broad
substrate
scope
excellent
functional
group
tolerance.
In
this
reaction,
sequential
C–C
bond
cleavage,
radical
addition,
processes
were
involved,
wherein
multiple
bonds
constructed
in
one-pot
reaction.
Mechanistic
studies
suggest
that
the
reaction
probably
proceeded
via
pathway.
Organic Chemistry Frontiers,
Год журнала:
2020,
Номер
7(14), С. 1948 - 1969
Опубликована: Янв. 1, 2020
We
summarized
recent
advances
in
cyclization
reactions
of
unsaturated
oxime
esters
(ethers),
which
provide
diversiform
functionalized
nitrogen-containing
scaffolds.
Angewandte Chemie,
Год журнала:
2017,
Номер
130(3), С. 752 - 756
Опубликована: Ноя. 8, 2017
Abstract
A
photoinduced
cascade
strategy
leading
to
a
variety
of
differentially
functionalised
nitriles
and
ketones
has
been
developed.
These
reactions
rely
on
the
oxidative
generation
iminyl
radicals
from
simple
oximes.
Radical
transposition
by
C(sp
3
)−(sp
)
)−H
bond
cleavage
gives
access
distal
carbon
that
undergo
S
H
2
functionalisations.
mild,
visible‐light‐mediated
procedures
can
be
used
for
remote
fluorination,
chlorination,
azidation,
were
applied
modification
bioactive
structurally
complex
molecules.
