Mild synthesis of isoxazoline derivatives via an efficient [4 + 1] annulation reaction of transient nitrosoalkenes and sulfur ylides

Scientific Reports, Год журнала: 2021, Номер 11(1)

Опубликована: Янв. 22, 2021

An efficient [4 + 1] annulation between α-bromooximes and sulfur ylides via in situ generation of nitrosoalkenes under mild basic reaction conditions has been developed, providing an expeditious scalable approach to synthesize biologically interesting isoxazoline derivatives with good excellent yields.

Язык: Английский

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Practical Synthesis of Isoindolines Yields Potent Colistin Potentiators in Multidrug-Resistant Acinetobacter baumannii

Organic & Biomolecular Chemistry, Год журнала: 2024, Номер 22(20), С. 4057 - 4061

Опубликована: Янв. 1, 2024

An efficient and practical one-pot synthesis of isoindolines from readily available starting materials was achieved under mild conditions by implementing an isoindole umpolung strategy. A variety were prepared with good to excellent yields. Biological screens these identified compounds demonstrated that they are potent potentiators colistin for multi-drug resistant

Язык: Английский

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Diethylsilane as a Powerful Reagent in Au Nanoparticle‐Catalyzed Reductive Transformations

European Journal of Organic Chemistry, Год журнала: 2020, Номер 2020(23), С. 3508 - 3514

Опубликована: Май 8, 2020

Diethylsilane (Et 2 SiH ), a simple and readily available dihydrosilane, that exhibits superior reactivity, as compared to monohydrosilanes, in series of reductive transformations catalyzed by recyclable reusable Au nanoparticles (1 mol‐%) supported on TiO . It reduces aldehydes or ketones almost instantaneously at ambient conditions. can be used one pot rapid amination procedure, which premixing aldehyde amine is required prior the addition reducing agent catalyst, even protic solvent. An unprecedented method for synthesis N ‐arylisoindolines also shown between o ‐phthalaldehyde anilines. In this transformation, it proposed intermediate ,2‐diphenylisoindolin‐1‐imines are reduced stepwise isoindolines. Finally, Et amides into amines excellent yields shorter reaction times relative previously known analogous nano (0) ‐catalyzed protocols.

Язык: Английский

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Accessing 2‐Aryl Quinolines via Acceptorless Dehydrogenation and Transfer Hydrogenation Under Base and Solvent‐Free Reaction Conditions

ChemistrySelect, Год журнала: 2023, Номер 8(45)

Опубликована: Дек. 1, 2023

Abstract Catalytic hydrogenation/dehydrogenation reactions are one of the most active areas research for synthesis pharmaceuticals and fine chemicals. Despite several efficient homogeneous catalysts that have already been identified, highly heterogeneous remain elusive. Herein, we report an easy convenient wet impregnation method Pd‐nanoclusters supported on ZnO nanoparticles. The catalyst displays a multifunctional role in 2‐aryl quinolines using alcohol 2‐nitrobenzyl as reactants via dehydrogenation/hydrogenation pathway under neat base‐free reaction conditions. exhibits excellent selectivity can be recycled five times without appreciable loss its activity.

Язык: Английский

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Metal–organic frameworks of Cu2(TPTC)-catalyzed cascade C–S coupling/Csp2–H hydroxylation reaction

Journal of the Iranian Chemical Society, Год журнала: 2020, Номер 17(6), С. 1339 - 1345

Опубликована: Янв. 28, 2020

Язык: Английский

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Efficient Synthesis of Phenoxathiines via the Cascade C–H Hydroxylation–C–S Coupling–C–O Cyclization Reaction

Russian Journal of General Chemistry, Год журнала: 2019, Номер 89(12), С. 2558 - 2561

Опубликована: Дек. 1, 2019

Язык: Английский

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