Hydrolysis, Ligand Exchange, and Redox Properties of Vanadium Compounds: Implications of Solution Transformation on Biological, Therapeutic, and Environmental Applications

Chemical Reviews, Год журнала: 2025, Номер unknown

Опубликована: Янв. 16, 2025

Vanadium is a transition metal with important industrial, technological, biological, and biomedical applications widespread in the environment living beings. The different reactions that vanadium compounds (VCs) undergo presence of proteins, nucleic acids, lipids metabolites under mild physiological conditions are reviewed. In present naturally or through anthropogenic sources, latter having an environmental impact caused by dispersion VCs atmosphere aquifers. has versatile chemistry interconvertible oxidation states, variable coordination number geometry, ability to form polyoxidovanadates various nuclearity structures. If VC added water-containing it can hydrolysis, ligand-exchange, redox, other types changes, determined speciation vanadium. Importantly, solution likely differ from introduced into system varies concentration. Here, hydrolytic ligand-exchange chemical reactions, influence pH, concentration, salt, specific solutes, biomolecules, on described. One our goals this work highlight need for assessment speciation, so beneficial toxic species might be identified mechanisms action elucidated.

Язык: Английский

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Optimizing Therapeutics for Intratumoral Cancer Treatments: Antiproliferative Vanadium Complexes in Glioblastoma

International Journal of Molecular Sciences, Год журнала: 2025, Номер 26(3), С. 994 - 994

Опубликована: Янв. 24, 2025

Glioblastoma, an aggressive cancer, is difficult to treat due its location, late detection, drug resistance, and poor absorption of chemotherapeutics. Intratumoral administration offers a promising potential treatment alternative with localized delivery minimal systemic toxicity. Vanadium(V) coordination complexes, incorporating Schiff base catecholate ligands, have shown effects as antiproliferative agents tunable efficacy reactivity, stability, steric bulk, hydrophobicity, uptake, toxicity optimized for the intratumoral vehicle. A new series oxovanadium(V) base–catecholate complexes were synthesized characterized using nuclear magnetic resonance (NMR), UV-Vis, infrared spectroscopy mass spectrometry. Stability under physiological conditions was assessed via UV-Vis spectroscopy, activity evaluated in T98G glioblastoma SVG p12 normal glial cells viability assays. The newly [VO(3-tBuHSHED)(TIPCAT)] complex more stable (t1/2 ~ 4.5 h) had strong (IC50 1.5 µM), comparing favorably current lead compound, [VO(HSHED)(DTB)]. structural modifications enhanced bulk through substitution iso-propyl tert-butyl groups. improved properties attributed hindrance associated catecholato well formation non-toxic byproducts upon degradation. emerges candidate therapy by demonstrating stability greater selectivity, which highlights role strategic ligand design developing therapies resistant cancers. In reporting class compounds effective against cells, we describe generally desirable that drugs being developed should have.

Язык: Английский

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Anticancer perspectives of vanadium complexes

Inorganic Chemistry Communications, Год журнала: 2024, Номер 161, С. 112014 - 112014

Опубликована: Янв. 5, 2024

Язык: Английский

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Solution chemistry and anti-proliferative activity against glioblastoma cells of a vanadium(V) complex with two bioactive ligands

Frontiers in Chemical Biology, Год журнала: 2024, Номер 3

Опубликована: Июль 5, 2024

Introduction: Glioblastoma is a brain cancer difficult to treat but recently mixed-ligand vanadium(V) Schiff base/catecholato complexes have exhibited high in vitro anti-proliferative activity. Hence, we explored the activity of [V V OL 1 L 2 ], which contains two iron chelating ligands, 2-hydroxy-1-naphthylaldehyde iso -nicotinoyhydrazone (L H ) and clioquinol H). This complex was previously reported be very effective against Trypanosoma cruzi , causative agent Chagas disease. These studies possibility that compound with efficacy also has human glioblastoma cells. Since ] poorly soluble water ligand dissociated from upon addition an aqueous environment, understanding speciation important interpret its biological Methods: Stability cell media were followed by UV/Vis spectroscopy determine relevance T98G cells, measured absence presence Fe(III). Results Discussion: The current work demonstrated vanadium coordination had (T98G) line. enhanced effects cells could due either hydrolysis release toxic clioquinol, or rapid uptake lipophilic prior hydrolysis. showed at least part potent toxicity stemmed bioactive complex, depended on whether Fe(III) present. (O) H)] most remained intact and, hence, active. Thus, future development should focus one-ligand making any more soluble, stable solution, designed rapidly taken up diseased

Язык: Английский

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Substitution Kinetics, Albumin and Transferrin Affinities, and Hypoxia All Affect the Biological Activities of Anticancer Vanadium(V) Complexes

Inorganic Chemistry, Год журнала: 2023, Номер 62(43), С. 17804 - 17817

Опубликована: Окт. 20, 2023

Limited stability of most transition-metal complexes in biological media has hampered their medicinal applications but also created a potential for novel cancer treatments, such as intratumoral injections cytotoxic short-lived anticancer drugs. Two related V(V) complexes, [VO(Hshed)(dtb)] (1) and [VO(Hshed)(cat)] (2), where H2shed = N-(salicylideneaminato)-N'-(2-hydroxyethyl)-1,2-ethanediamine, H2dtb 3,5-di-tert-butylcatechol, H2cat 1,2-catechol, decomposed within minutes cell culture medium at 310 K (t1/2 43 9 s 1 2, respectively). Despite this, both showed high antiproliferative activities triple-negative human breast (MDA-MB-231) cells, the mechanisms were radically different. Complex formed noncovalent adducts with serum albumin, rapidly entered cells via passive diffusion, was nearly active short-term treatment (IC50 1.9 ± 0.2 μM 30 min) compared long-term 1.3 72 h). The activity decreased about 20-fold after its decomposition min K. 2 similar ≈ 12 h) fresh solutions inactive treatment. mainly due to reactions among products, free catechol, O2 medium. As result, less sensitive than that effects hypoxic conditions are characteristic solid tumors presence apo-transferrin acts scavenger V(V/IV) products blood serum. In summary, complex 1, not is suitable candidate further development an drug delivered injections. These results demonstrate importance fine-tuning ligand properties optimization metal complexes.

Язык: Английский

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Halogenated non-innocent vanadium(v) Schiff base complexes: chemical and anti-proliferative properties

New Journal of Chemistry, Год журнала: 2024, Номер 48(29), С. 12893 - 12911

Опубликована: Янв. 1, 2024

Halogenated non-innocent vanadium( v ) Schiff base mono-substituted catecholates have a low stability and anti-proliferative properties similar to vanadate. A linear correlation between complex redox potential the catechol p K was observed.

Язык: Английский

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Reactivity in cell culture medium and in vitro anticancer activity of 3,5-di-tert-butylcatechol: link to metal-catechol interactions

Frontiers in Chemical Biology, Год журнала: 2025, Номер 4

Опубликована: Фев. 3, 2025

Introduction Catechol moieties are common in natural bioactive molecules, and their ability to bind metal ions is widely explored both naturally with siderophores the development of metal-based drugs. The reactivities biology activities a sterically hindered model catechol compound, 3,5-di- tert -butylcatechol (dtbH 2 ) its oxidation product -butyl- o -quinone (dtbQ), were studied cell culture medium understand better medicinal roles this class molecules. Methods Anti-proliferative dtbH dtbQ fresh aged solutions molecules two human cancer lines, T98G (glioblastoma) A549 (lung carcinoma). Electrospray mass spectrometry UV/Vis spectroscopy used study buffer medium, presence absence glutathione imidazole. Results Discussion showed high anti-proliferative activity (IC 50 < 10 μM 72 h assays) lines added ions. was observed when freshly while pre-incubation for 24 reduced 5-10-fold. This deactivation avoided biological reductant, (GSH), at physiologically relevant intracellular concentration (5.0 mM). These results explained by speciation studies (UV/Vis spectrometry) aqueous buffers, or organic solvents GSH. that redox equilibrium established between dtbQ, latter rapidly coupling GSH an oxidative manner. resultant adduct likely be responsible toxicity GSH-rich cells via oxygen-dependent radical chain reactions. Deactivation due reactions nucleophiles, such as amino acids, followed formation polymeric species. reported V(V)-catecholato complexes can combination efficient cellular uptake rapid decomposition thiol-rich environment active V(V) /dtbQ adducts thiols (mainly GSH). Slower thiol-poor extracellular environments. data show crucial not only but also ligands dissociates.

Язык: Английский

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Coordination Polymers of Vanadium and Selected Metal Ions with N,O-Donor Schiff Base Ligands—Synthesis, Crystal Structure, and Application

Molecules, Год журнала: 2025, Номер 30(5), С. 1104 - 1104

Опубликована: Фев. 27, 2025

This review provides an overview of the synthesis, characterization and application coordination polymers based on N,O-donor Schiff base ligands. The (CPs) represent a novel class inorganic-organic hybrid materials with tunable compositions fascinating structures. They are composed metal ions organic Therefore, nature ion type ligand is most significant factor in constructing targeted desired properties. Due to versatile modes, ligands also used construct various CPs.

Язык: Английский

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Synthesis, crystal structure, computational and solution studies of a new phosphotetradecavanadate salt. Assessment of its effect on U87 glioblastoma cells

Journal of Inorganic Biochemistry, Год журнала: 2025, Номер 269, С. 112882 - 112882

Опубликована: Март 9, 2025

Язык: Английский

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Insights into the Theranostic Activity of Nonoxido V^IV: Lysosome-Targeted Anticancer Metallodrugs

Inorganic Chemistry, Год журнала: 2024, Номер 63(41), С. 19418 - 19438

Опубликована: Сен. 28, 2024

Developing new anticancer agents can be useful, with the ability to diagnose and treat cancer worldwide. Previously, we focused on examining effects of nonoxidovanadium(IV) complexes insulin mimetic cytotoxicity activity. In this study, in addition cytotoxic activity, evaluated their bioimaging properties. This study investigates synthesis four stable nonoxido V

Язык: Английский

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