Frontiers in Microbiology,
Год журнала:
2024,
Номер
15
Опубликована: Июнь 19, 2024
Introduction
Porcine
reproductive
and
respiratory
syndrome
virus
(PRRSV)
causes
substantial
economic
losses
in
the
global
swine
industry.
The
current
vaccine
options
offer
limited
protection
against
PRRSV
transmission,
there
are
no
effective
commercial
antivirals
available.
Therefore,
is
an
urgent
need
to
develop
new
antiviral
strategies
that
slow
transmission.
Methods
In
this
study,
we
synthesized
a
dicoumarol-graphene
oxide
quantum
dot
(DIC-GQD)
polymer
with
excellent
biocompatibility.
This
was
via
electrostatic
adsorption
method
using
natural
drug
DIC
GQDs
as
raw
materials.
Results
Our
findings
demonstrated
exhibits
high
anti-PRRSV
activity
by
inhibiting
replication
stage.
transcriptome
sequencing
analysis
revealed
treatment
stimulates
genes
associated
Janus
kinase/signal
transducer
activator
of
transcription
(JAK/STAT)
signalling
pathway.
porcine
alveolar
macrophages
(PAMs),
DIC-GQDs
induce
TYK2,
JAK1,
STAT1,
STAT2
phosphorylation,
leading
upregulation
STAT2,
interferon-β
(IFN-β)
interferon-stimulated
(ISGs).
Animal
challenge
experiments
further
confirmed
effectively
alleviated
clinical
symptoms
pathological
reactions
lungs,
spleen,
lymph
nodes
PRRSV-infected
pigs.
Discussion
These
suggest
significantly
inhibits
proliferation
activating
JAK/STAT
hold
promise
alternative
for
infection.
Nature Reviews Bioengineering,
Год журнала:
2023,
Номер
1(2), С. 88 - 106
Опубликована: Янв. 27, 2023
From
small
molecules
to
entire
organisms,
evolution
has
refined
biological
structures
at
the
nanoscale,
microscale
and
macroscale
be
chiral—that
is,
mirror
dissymmetric.
Chirality
results
in
biological,
chemical
physical
properties
that
can
influenced
by
circularly
polarized
electromagnetic
fields.
Chiral
nanoscale
materials
designed
mimic,
refine
advance
chiral
geometries,
engineer
optical,
for
applications
photonics,
sensing,
catalysis
biomedicine.
In
this
Review,
we
discuss
mechanisms
underlying
chirality
transfer
nature
provide
design
principles
nanomaterials.
We
highlight
how
features
emerge
inorganic
during
synthesis
of
nanostructures,
outline
key
nanomaterials,
including
promising
designs
biomedical
applications,
such
as
biosensing
immunomodulation.
conclude
with
an
outlook
future
opportunities
challenges,
need
characterization
techniques.
nanomaterials
induce
specific
physical,
phenomena.
This
Review
discusses
biomolecules
light
allow
control
which
applied
optical
devices,
Advanced Functional Materials,
Год журнала:
2024,
Номер
34(38)
Опубликована: Апрель 30, 2024
Abstract
Microbial
infections
pose
a
significant
threat
to
public
health,
exacerbated
by
the
escalating
issue
of
antibiotic
resistance
resulting
from
their
overuse.
Chiral
carbon
dots
(CDs)
not
only
inherit
antibacterial
properties
CDs
but
also
demonstrate
highly
selective
chiral
bactericidal
activity.
This
study
focuses
on
development
synthesized
D‐
and
L‐cysteine,
selectively
identify
synergistically
eradicate
Gram‐positive
bacteria
fungi.
exhibit
high
efficacy
in
staining
fungi
while
demonstrating
minimal
no
fluorescence
with
Gram‐negative
bacteria,
attributable
variances
membrane
structures
these
pathogens.
D‐CDs
stronger
signals
greater
against
compared
L‐CDs.
Under
dual
light
irradiation,
bolster
activity
through
triple‐modal
mechanism,
involving
disruption
absence
light,
singlet
oxygen
generation
during
photodynamic
therapy,
elevated
temperature
photothermal
treatment.
Animal
studies
additionally
showcase
that
notably
enhanced
healing
wounds
infected
S.
aureus
under
laser
exposure.
investigation
underscores
chiral‐specific
imaging
potentials
D‐CDs,
paving
way
for
advancement
nanomaterials
bacterial
diagnostics
therapy.
ABSTRACT
Chirality,
the
property
of
molecules
having
mirror‐image
forms,
plays
a
crucial
role
in
pharmaceutical
and
biomedical
research.
This
review
highlights
its
growing
importance,
emphasizing
how
chiral
drugs
nanomaterials
impact
drug
effectiveness,
safety,
diagnostics.
Chiral
serve
as
precise
diagnostic
tools,
aiding
accurate
disease
detection
through
unique
biomolecule
interactions.
The
article
extensively
covers
applications
treating
cardiovascular
diseases,
CNS
disorders,
local
anesthesia,
anti‐inflammatories,
antimicrobials,
anticancer
drugs.
Additionally,
it
explores
emerging
field
nanomaterials,
highlighting
their
suitability
for
diagnostics
therapeutics,
enhancing
medical
treatments.
Advanced Optical Materials,
Год журнала:
2023,
Номер
11(8)
Опубликована: Фев. 15, 2023
Abstract
Organic–inorganic
hybrid
copper(I)‐based
halides
have
attracted
great
interest
in
the
field
of
optoelectronics
due
to
their
low
cost,
non‐toxicity,
large
Stokes
shift,
and
high
photoluminescence
quantum
yields
(PLQYs).
Here,
bulk
zero‐dimensional
(0D)
organic‐inorganic
(R,S‐2‐mpip)
2
Cu
I
6
(mpip
=
methylpiperazinium,
C
5
H
14
N
2+
)
single
crystals
been
grown
with
equal
stoichiometric
ratios
R‐
S‐2‐mpip
ligands
by
chirality–racemization
strategy
for
first
time.
Interestingly,
exhibit
strong
blue–green
(PL)
located
at
520
nm
shift
about
230
PLQY
65.96%,
which
originates
from
self‐trapped
excitons
(STEs).
More
importantly,
also
radioluminescence
(RL)
nm,
fast
X‐ray
scintillation
response
a
light
yield
47
000
photon
MeV
−1
detection
limit
6.48
nGy
air
s
when
exposed
irradiation
condition,
is
superior
that
other
copper(I)
iodide‐based
hybrids.
Based
on
excellent
characteristics,
imaging
systems
based
clear
images
“QFNU”
logo
crystal
symbol
pattern.
This
work
not
only
deepens
understandings
material
design
fundamental
properties
these
racemate
systems,
but
provides
guidance
further
applications
multi‐functional
optoelectronics.
The Journal of Physical Chemistry Letters,
Год журнала:
2023,
Номер
15(1), С. 113 - 120
Опубликована: Дек. 26, 2023
Although
chirality
plays
an
important
role
in
the
natural
world,
it
has
also
attracted
much
scientific
attention
nanotechnology,
particular,
spintronics
and
bioapplications.
Chiral
carbon
dots
(CDs)
are
promising
nanoparticles
for
sensing
bioimaging
since
they
biocompatible,
ecofriendly,
free
from
toxic
elements.
Herein,
green
red
emissive
chiral
CDs
fabricated
via
surface
modification
treatment
of
achiral
at
room
temperature.
After
with
l-cysteine
molecules,
treated
demonstrate
intense
signal
region
200–300
nm
a
dissymmetry
factor
up
to
2.3
×
10–4
high
photoluminescence
quantum
yields
19%
15%
emission
bands,
respectively.
These
preserve
their
different
ion
systems,
such
as
those
pH
changes
or
presence
metal
ions,
along
remarkably
low
cytotoxicity,
making
them
potential
candidates
use
photoluminescent
labels
biological
objects.
