Catalysis Today,
Год журнала:
2023,
Номер
426, С. 114389 - 114389
Опубликована: Сен. 20, 2023
In
this
work,
the
asymmetric
catalytic
activity
of
recently
discovered
GTM-3
chiral
zeolite
is
systematically
explored
for
ring-opening
trans-stilbene
oxide
using
alcohols
different
size
as
nucleophiles.
Catalytic
results
show
a
volcano-type
curve
with
clear
maximum
enantioselective
specific
linear
alcohol
4
C
(1-butanol);
perfectly
reproduced
in
opposite
sign
catalysts
obtained
antipode
structure-directing
agent.
Such
trend
evidences
that
proper
host-guest
match
must
be
established
between
reactants
and/or
transition
states
and
confined
space
provided
by
framework
order
catalyst
to
manifest
its
chirality.
Moreover,
secondary
alcohols,
bulkier
size,
give
higher
enantioselectivities
than
their
counterparts.
On
other
hand,
variation
reaction
conditions
enables
maximize
enantioselectivity
reaction:
particular,
concentration
epoxide
displays
strong
influence,
notably
improving
enantiomeric
excess
when
reduced.
Modification
temperature
also
influences
excess,
especially,
selectivity
products.
Our
suggest
if
within
nanospace
framework,
then
well
products
maximized,
which
indeed
can
manipulated
through
variations
conditions,
leading
unprecedented
values
up
51%.
Molecules,
Год журнала:
2023,
Номер
28(20), С. 7165 - 7165
Опубликована: Окт. 19, 2023
Peptides
are
at
the
cutting
edge
of
contemporary
research
for
new
potent,
selective,
and
safe
therapeutical
agents.
Their
rise
has
reshaped
pharmaceutical
landscape,
providing
solutions
to
challenges
that
traditional
small
molecules
often
cannot
address.
A
wide
variety
natural
modified
peptides
have
been
obtained
studied,
many
others
advancing
in
clinical
trials,
covering
multiple
therapeutic
areas.
As
demand
peptide-based
therapies
grows,
so
does
need
sustainable
environmentally
friendly
synthesis
methods.
Traditional
peptide
synthesis,
while
effective,
involves
draining
processes,
generating
significant
waste
consuming
vast
resources.
The
integration
green
chemistry
offers
alternatives,
prioritizing
eco-friendly
reduction,
energy
conservation.
This
review
delves
into
transformative
potential
applying
principles
by
discussing
relevant
examples
application
such
approaches
production
active
ingredients
(APIs)
with
a
structure
how
these
efforts
critical
an
effective
transition
era
field.
Catalysts,
Год журнала:
2024,
Номер
14(1), С. 84 - 84
Опубликована: Янв. 19, 2024
Biocatalysis
holds
immense
potential
for
pharmaceutical
development
as
it
enables
synthetic
routes
to
various
chiral
building
blocks
with
unparalleled
selectivity.
Therein,
solvent
and
water
use
account
a
large
contribution
the
environmental
impact
of
reactions.
In
spirit
Green
Chemistry,
transition
from
traditional
highly
diluted
aqueous
systems
intensified
non-aqueous
media
overcome
limitations
(e.g.,
shortages,
recalcitrant
wastewater
treatments,
low
substrate
loadings)
has
been
observed.
Benefiting
spectacular
advances
in
enzyme
stabilization
techniques,
plethora
biotransformations
non-conventional
have
established.
Deep
eutectic
solvents
(DESs)
emerge
sort
(potentially)
greener
medium
increasing
biocatalysis.
This
review
discusses
state-of-the-art
DESs
focus
on
biocatalytic
pathways
synthesis
active
ingredients
(APIs).
Representative
examples
different
classes
are
discussed,
together
critical
vision
discussing
prospects
using
Molecules,
Год журнала:
2025,
Номер
30(4), С. 939 - 939
Опубликована: Фев. 18, 2025
Enzyme
immobilization
plays
a
critical
role
in
enhancing
the
efficiency
and
sustainability
of
biocatalysis,
addressing
key
challenges
such
as
limited
enzyme
stability,
short
shelf
life,
difficulties
recovery
recycling,
which
are
pivotal
for
green
chemistry
industrial
applications.
Classical
approaches,
including
adsorption,
entrapment,
encapsulation,
covalent
bonding,
well
advanced
site-specific
methods
that
integrate
engineering
bio-orthogonal
chemistry,
were
discussed.
These
techniques
enable
precise
control
over
orientation
interaction
with
carriers,
optimizing
catalytic
activity
reusability.
Key
findings
highlight
impact
on
improving
performance
under
various
operational
conditions
its
reducing
process
costs
through
enhanced
stability
recyclability.
The
review
presents
numerous
practical
applications
immobilized
enzymes,
their
use
pharmaceutical
industry
drug
synthesis,
food
sector
dairy
processing,
environmental
biotechnology
wastewater
treatment
dye
degradation.
Despite
significant
advantages,
loss
due
to
conformational
changes
mass
transfer
limitations
remain,
necessitating
tailored
protocols
specific
integration
modern
biotechnological
advancements,
site-directed
mutagenesis
recombinant
DNA
technology,
offers
promising
pathway
developing
robust,
efficient,
sustainable
biocatalytic
systems.
This
comprehensive
guide
aims
support
researchers
industries
selecting
diverse
pharmaceuticals,
fine
chemicals.
Chirality,
Год журнала:
2022,
Номер
34(11), С. 1403 - 1418
Опубликована: Авг. 5, 2022
Abstract
Over
the
last
decades,
biocatalysis
has
achieved
growing
interest
thanks
to
its
potential
enable
high
efficiency,
yield,
and
eco‐friendly
processes
aimed
at
production
of
pharmacologically
relevant
compounds.
Particularly,
proved
an
effective
potent
tool
in
preparation
chiral
molecules,
recent
innovations
biotechnologies
nanotechnologies
open
up
a
new
era
further
developments
this
field.
Different
strategies
are
now
available
for
synthesis
drugs
their
intermediates.
Enzymes
green
tools
that
offer
several
advantages,
associated
both
catalysis
environmentally
friendly
reactants.
Specifically,
use
enzymes
isolated
from
biological
sources
or
whole‐cell
represents
valuable
approach
obtain
pharmaceutical
products.
The
sustainability,
higher
cost‐effectiveness
biocatalytic
reactions
result
improved
performance
properties
can
be
translated
academia
industry.
In
review,
we
focus
on
approaches
synthesizing
Aiming
unveil
potentialities
systems,
discuss
different
examples
innovative
applications
LabMed discovery.,
Год журнала:
2024,
Номер
1(1), С. 100008 - 100008
Опубликована: Июль 29, 2024
Chirality
is
one
of
the
essential
attributes
nature.
Chiral
drugs
refer
to
a
class
containing
chiral
centers,
and
molecular
stereo-structures
their
enantiomers
are
non-superimposable
mirror
images
each
other.
Sixty
percent
commonly
used
drugs,
including
those
from
traditional
Chinese
medicine
(TCM),
chiral.
Developing
single
enantiomer
with
high
efficiency
low
toxicity
has
drawn
considerable
attention
due
significant
differences
in
pharmacological
activities,
metabolic
processes,
exhibited
by
drugs.
This
review
concisely
summarizes
sources,
absolute
configuration
identification,
applications,
future
research
trends,
particularly
TCM.
PeerJ,
Год журнала:
2024,
Номер
12, С. e17589 - e17589
Опубликована: Июль 8, 2024
Nanobiocatalysts
(NBCs),
which
merge
enzymes
with
nanomaterials,
provide
a
potent
method
for
improving
enzyme
durability,
efficiency,
and
recyclability.
This
review
highlights
the
use
of
eco-friendly
synthesis
methods
to
create
sustainable
nanomaterials
transport.
We
investigate
different
immobilization,
such
as
adsorption,
ionic
covalent
bonding,
entrapment,
cross-linking,
examining
their
pros
cons.
The
decreased
environmental
impact
green-synthesized
from
plants,
bacteria,
fungi
is
emphasized.
exhibits
various
uses
NBCs
in
food
industry,
biofuel
production,
bioremediation,
showing
how
they
can
enhance
effectiveness
eco-friendliness.
Furthermore,
we
explore
potential
biomedicine.
In
general,
green
nanobiocatalysts
are
notable
progression
technology,
leading
environmentally-friendly
effective
biocatalytic
that
have
important
impacts
on
industrial
biomedical
fields.
Catalysts,
Год журнала:
2023,
Номер
13(5), С. 902 - 902
Опубликована: Май 17, 2023
Biorefineries
have
been
profiled
as
potential
alternatives
to
increase
biomass
use
at
the
industrial
level.
However,
more
efforts
are
required
improve
sustainability
of
these
facilities
through
process
improvement
and
product
portfolio
increase.
The
catalytic
conversion
chemicals
energy
vectors
is
one
most
studied
research
lines
today.
open
literature
has
described
pathways
for
producing
biofuels
platform
molecules
using
this
renewable
resource.
Nevertheless,
few
reviews
aimed
analyze
role
in
biorefineries
while
considering
following
items:
(i)
biocatalysis,
(ii)
carbon
dioxide
conversion,
(iii)
design
based
on
upgrading,
(iv)
metrics.
This
paper
several
processes
where
catalysis
applied
yields
elucidate
field
boost
implementation
different
productive
sectors.
provides
an
overview
into
a
series
high-value-added
products,
involving
key
topics
related
catalyst
performance,
use,
applications,
recent
trends.
In
addition,
gaps
ideas
highlighted
previous
studies.
conclusion,
biorefineries’
sustainability.
studies
focused
production
new
catalysts
resources,
techno-economic
environmental
assessment
catalysis,
influence
valorization
via
heterogeneous
existing
obtain
real
understanding
upgrades’
benefits.
