Recent Advances of 2‐Nitroglycals as Powerful Glycosyl Donors
European Journal of Organic Chemistry,
Год журнала:
2024,
Номер
27(18)
Опубликована: Март 2, 2024
Abstract
2‐Nitroglycals
are
important
synthons
for
biological
active
2‐aminoglycosides,
glycoconjugates
and
natural
products
synthesis.
Herein,
we
summarized
the
recent
advances
of
2‐nitroglycals
including
its
synthetic
methods
applications.
Using
2‐nitroglycals,
nitro‐polyol
derivatives,
sugar‐furan
sugar‐pyrrole
molecules,
2,3‐diaminoglycosides
2‐amino‐1,3‐dithioglycosides
were
obtained
via
Michael–type
addition,
retro‐Henry‐type
reaction,
C1/C3‐Ferrier
rearrangement
[3+2]
N
‐heterocyclic
addition.
Most
these
conversions
achieved
mild
organo‐catalysis
glycosylation
methods.
Язык: Английский
Synthesis and immunological study of tetrasaccharide repeating units of capsular polysaccharide of Group B Streptococcus serotype VIII and their protein conjugates
Journal of Carbohydrate Chemistry,
Год журнала:
2024,
Номер
unknown, С. 1 - 33
Опубликована: Окт. 9, 2024
This
study
reports
the
efficient
synthesis
of
three
tetrasaccharide
derivatives
Group
B
Streptococcus
(GBS)
serotype
VIII
capsular
polysaccharide
with
alternative
glycan
sequences
and
spacer
chains
through
a
convergent
chemical
glycosylation
manner
or
one-pot
three-enzyme
assembly
protocol.
Using
bifunctional
glutarate
ester
as
linker,
these
synthesized
oligosaccharides
were
efficiently
conjugated
recombinant
ScpA193
protein,
generating
resultant
oligosaccharide-ScpA193
conjugates
desirable
carbohydrate
loading.
ELISA
analysis
antisera
obtained
from
mice
inoculated
synthetic
glycoconjugates
showed
elicitation
strong
oligosaccharide-specific
immunoglobulin
G
(IgG)
antibodies,
suggesting
potential
for
use
in
development
GBS
vaccines.
Язык: Английский