Photoinduced radical-polar crossover cyclization reactions

Chem Catalysis, Год журнала: 2024, Номер 4(5), С. 100945 - 100945

Опубликована: Март 5, 2024

Язык: Английский

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An electrocatalytic mono-functionalization of alkenes towards alkenyl selenium sulfonates

Chemical Communications, Год журнала: 2025, Номер unknown

Опубликована: Янв. 1, 2025

In this study, a straightforward and environmentally benign electrochemical mono-functionalization of alkenes has been established for the synthesis alkenyl selenium sulfonates using elemental as source.

Язык: Английский

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Visible‐Light‐Induced Domino Cyclization to Access Pyrido[2,3‐d]pyrimidine‐2,4‐diones via a Radical‐Polar Crossover Reaction

Chinese Journal of Chemistry, Год журнала: 2024, Номер 42(19), С. 2346 - 2350

Опубликована: Май 27, 2024

Comprehensive Summary Catalytic and green strategies for the synthesis of privileged scaffolds are synthetically appealing. We now report a radical‐polar crossover (RPC)‐enabled three‐component cyclization bromodifluoroalkyls with enaminones 6‐aminouraciles via visible‐light‐induced domino cyclization. The reaction exhibited broad substrate scope (> 40 examples) including complex molecules, which highlighted utility this strategy construction library bioactive analogs.

Язык: Английский

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Synergistic Brønsted Base/Photoredox‐Catalyzed Three‐Component Coupling with Malonates to Synthesize δ‐Hydroxy Esters and δ‐Keto Esters

Chinese Journal of Chemistry, Год журнала: 2024, Номер 42(9), С. 957 - 962

Опубликована: Янв. 18, 2024

Comprehensive Summary Multicomponent alkene 1,2‐dicarbofunctionalizations (DCFs) have emerged as a powerful strategy to rapidly incorporate both two carbon subunits across one C—C double bond in step for enhancing molecular complexity and diversity. To the best of our knowledge, there is only report on photoredox‐catalyzed three‐component DCFs with malonates through radical−radical cross‐coupling, while radical‐polar crossover (RPC)‐type were still rare. Herein, we describe redox‐neutral RPC‐type 1,2‐dialkylation styrenes aldehydes synergistic Brønsted base/photoredox catalysis system. This transition‐metal‐free provides an efficient clean approach broad variety δ‐hydroxy esters also features exceptionally mild conditions, wide compatibility substrate scope functional groups, high atomic economy. Moreover, 1,2‐alkylacylation from same starting materials was achieved one‐pot manner such coupling subsequent two‐electron oxidation process, providing set δ‐keto interest pharmaceutical research.

Язык: Английский

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Divergent functionalization of alkenes enabled by photoredox activation of CDFA and α-halo carboxylic acids

Chemical Science, Год журнала: 2024, Номер 15(27), С. 10659 - 10667

Опубликована: Янв. 1, 2024

The direct activation of α-halo carboxylic acids using visible-light-mediated photoredox catalysis facilitates the formation bifunctional radical intermediates, allowing reactivity toward olefins to be fine-tuned by varying solvent system.

Язык: Английский

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Photoinduced Metal‐/Additive‐Free Difluoromethylation of N‐Heteroaromatics^†

Chinese Journal of Chemistry, Год журнала: 2025, Номер unknown

Опубликована: Янв. 16, 2025

Comprehensive Summary Herein, we report a photo‐induced, metal‐/additive‐free protocol for the difluoromethylation of N ‐heteroaromatics with [bis(difluoroacetoxy)iodo]benzene as reagent. The affords difluoromethylated in moderate to good yield (up 91%). transformation is compatible wide range substrates and has tolerance towards various functional groups. Moreover, synthetic value this method further demonstrated by applications gram‐scale synthesis late‐stage functionalization biologically important molecules.

Язык: Английский

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N-Heterocyclic nitrenium-catalyzed triple domino reaction of organic iodides for the synthesis of phthalides and δ-lactones

Green Synthesis and Catalysis, Год журнала: 2025, Номер unknown

Опубликована: Апрель 1, 2025

Язык: Английский

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Synthesis of trans‐2‐(Disubstituted‐amino)alkenyl Polyoxyperfluoroalkyl Ketones from Tertiary Amines and Perfluoroalkyl Ether Carboxylates Featuring “–CF₂O–” Units^†

Chinese Journal of Chemistry, Год журнала: 2025, Номер unknown

Опубликована: Апрель 25, 2025

Comprehensive Summary A one‐pot transformation of aliphatic and aromatic tertiary amines to novel fluorinated enaminones has been developed, utilizing perfluoroalkyl ether carboxylates (PFECA salts) featuring “–CF 2 O–” units as the fluorine‐containing reagents. Carbonyl fluoride, acyl fluorides anhydrides by thermal decomposition these PFECA salts were proposed act key active species that trigger tandem oxidation–acylation process amines, through enamine intermediates.

Язык: Английский

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Photoinduced Metal-Free Radical Addition/Cyclization of 2-Cyanoaryl Acrylamides to Prepare gem-Difluorinated Naphthyridinone Scaffolds

The Journal of Organic Chemistry, Год журнала: 2024, Номер 89(15), С. 10831 - 10843

Опубликована: Июль 11, 2024

Direct construction of

Язык: Английский

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