Cobalt-Catalyzed Cascade Synthesis of 5-Amino-1,2,4-triazolo[1,5-c]quinazoline Derivatives via Multiple C–N Bonds Construction
The Journal of Organic Chemistry,
Год журнала:
2025,
Номер
unknown
Опубликована: Май 28, 2025
A
cobalt-catalyzed
three-component
cascade
reaction
for
the
synthesis
of
functionalized
5-amino-1,2,4-triazolo[1,5-c]quinazoline
derivatives
is
presented.
The
involves
ortho-cyanoaryl
isocyanides,
azides,
and
hydrazides,
giving
products
in
good
to
excellent
yields.
protocol
highly
scalable,
as
demonstrated
by
a
gram-scale
bioactive
CGS-15943,
providing
robust,
efficient
method
synthesizing
triazoloquinazoline
offering
significant
potential
drug
discovery
further
modifications.
Язык: Английский
[1,2]‐Phospha‐Brook Rearrangement‐Initiated Palladium‐Catalyzed Cyclization Reaction of Isocyanides and o‐Bromobenzaldehydes: Access to 2H‐Isoindole‐1‐carboxamides and 2H‐Isoindole‐1‐carbonitriles
Chinese Journal of Chemistry,
Год журнала:
2024,
Номер
unknown
Опубликована: Дек. 20, 2024
Comprehensive
Summary
Herein,
a
[1,2]‐phospha‐Brook
rearrangement‐initiated
palladium‐catalyzed
cyclization
reaction
for
base‐controlled
selective
synthesis
of
2
H
‐isoindole‐1‐carboxamide
and
‐isoindole‐1‐carbonitrile
derivatives
has
been
described.
This
strategy
features
double
isocyanide
insertion,
efficient
bond
combinations,
simple
operation
conditions.
Mechanistic
studies
show
that
the
rearrangement
is
key
step
in
this
reaction.
protocol
offers
novel
concise
‐isoindole
derivatives.
Язык: Английский