Catalytic atroposelective synthesis of indolyl quinazolinones bearing N–N/C–C diaxes

Science China Chemistry, Год журнала: 2025, Номер unknown

Опубликована: Янв. 9, 2025

Язык: Английский

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Transition-metal-catalyzed enantioselective C–N cross-coupling

Chemical Society Reviews, Год журнала: 2024, Номер 53(19), С. 9560 - 9581

Опубликована: Янв. 1, 2024

Chiral amine scaffolds are among the most important building blocks in natural products, drug molecules, and functional materials, which have prompted chemists to focus more on their synthesis. Among accomplishments chiral synthesis, transition-metal-catalyzed enantioselective C-N cross-coupling is considered one of efficient protocols. This approach combines traditional C(sp

Язык: Английский

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Applications of innovative synthetic strategies in anticancer drug Discovery: The Driving Force of new chemical reactions

Bioorganic & Medicinal Chemistry Letters, Год журнала: 2025, Номер 119, С. 130096 - 130096

Опубликована: Янв. 9, 2025

Язык: Английский

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Enantioconvergent and diastereoselective synthesis of atropisomeric hydrazides bearing a cyclic quaternary stereocenter through ternary catalysis

Chemical Science, Год журнала: 2024, Номер 15(33), С. 13240 - 13249

Опубликована: Янв. 1, 2024

The enantioselective and diastereoselective synthesis of atropisomeric hydrazides with defined vicinal central axial chirality via ternary catalysis in a one-pot process is reported.

Язык: Английский

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Asymmetric synthesis of acyclic N–N axially chiral indole compounds via catalytic N-acylation reaction

Organic Chemistry Frontiers, Год журнала: 2024, Номер 11(19), С. 5437 - 5442

Опубликована: Янв. 1, 2024

Herein, we present an enantioselective synthesis of N -aminoindoles bearing a N–N axis via chiral isothiourea catalyzed asymmetric -acylation. Notably, some the products exhibited promising cytotoxicity activities against cancer cell lines.

Язык: Английский

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Catalytic Atroposelective Synthesis of N–N Axially Chiral Indolylamides

The Journal of Organic Chemistry, Год журнала: 2024, Номер 89(17), С. 12559 - 12575

Опубликована: Авг. 27, 2024

The catalytic atroposelective synthesis of N–N axially chiral indolylamides was established via dynamic kinetic resolution, which makes use Lewis base-catalyzed asymmetric acylation N-acylaminoindoles as a new type platform molecule with anhydrides. By this strategy, series were synthesized in overall good yields (up to 98%) excellent enantioselectivities 99% ee). Moreover, some these display extent anticancer activity, demonstrates their potential application medicinal chemistry. Therefore, work has not only provided strategy for the monoaryl indoles but also offered member configurational stability and promising application, thereby solving challenges indoles.

Язык: Английский

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Recent advances in the catalytic asymmetric construction of axially chiral azole-based frameworks

Organic Chemistry Frontiers, Год журнала: 2024, Номер 11(23), С. 6819 - 6849

Опубликована: Янв. 1, 2024

This review highlights recent advances in the atroposelective preparation of axially chiral azole derivatives, emphasizing mechanistic insights and synthetic applications development this class five-membered heterocyclic frameworks.

Язык: Английский

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Chiral phosphoric acid-catalyzed atroposelective oxidative coupling of carbazoles

Science China Chemistry, Год журнала: 2025, Номер unknown

Опубликована: Март 14, 2025

Язык: Английский

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Enantioselective electrochemical and photochemical synthesis of atropisomers

Trends in Chemistry, Год журнала: 2024, Номер 6(9), С. 556 - 571

Опубликована: Июль 23, 2024

Язык: Английский

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Discovery and Enantioselective Synthesis of Tetra-Substituted Methylene Oxindole Atropisomers by Palladium-Catalyzed Domino Cyclization

ACS Catalysis, Год журнала: 2024, Номер 14(18), С. 13892 - 13902

Опубликована: Сен. 4, 2024

Язык: Английский

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