Functionalized Carbon Nanotubes: Emerging Nanomaterials for Enhanced Cancer Diagnosis and Imaging DOI Creative Commons

Anish Prasad Lohani,

Mohamed Elosta,

M. I. A. Abdel Maksoud

и другие.

Molecules, Год журнала: 2025, Номер 30(11), С. 2364 - 2364

Опубликована: Май 29, 2025

Cancer remains a leading global cause of mortality, highlighting the critical need for effective early diagnosis. Despite advancements in treatment, detection and imaging continue to pose significant challenges. Functionalized carbon nanotubes (CNTs) have emerged as promising nanomaterials due their unique structural properties versatile functionalization strategies. This review explores role both covalent (e.g., fluorination, hydrogenation, cycloadditions, aryldiazonium salt reduction, organometallic ion attachment, carboxylation, amidation, esterification, metallic nanoparticle attachments) non-covalent methods surfactant coating, polymer wrapping, biomolecule encapsulation) enhancing CNT biocompatibility diagnostic efficiency. CNTs are extensively applied cancer through highly sensitive biosensors, including electrochemical, optical, field-effect transistor-based systems, capable detecting various biomarkers with exceptional sensitivity. Additionally, they offer advantages modalities such fluorescence imaging, magnetic resonance (MRI), computed tomography (CT), ultrasound improving contrast, resolution, specificity. also discusses challenges future directions development CNT-based platforms, emphasizing continued research advance clinical translation integration into routine diagnostics.

Язык: Английский

Functionalized Carbon Nanotubes: Emerging Nanomaterials for Enhanced Cancer Diagnosis and Imaging DOI Creative Commons

Anish Prasad Lohani,

Mohamed Elosta,

M. I. A. Abdel Maksoud

и другие.

Molecules, Год журнала: 2025, Номер 30(11), С. 2364 - 2364

Опубликована: Май 29, 2025

Cancer remains a leading global cause of mortality, highlighting the critical need for effective early diagnosis. Despite advancements in treatment, detection and imaging continue to pose significant challenges. Functionalized carbon nanotubes (CNTs) have emerged as promising nanomaterials due their unique structural properties versatile functionalization strategies. This review explores role both covalent (e.g., fluorination, hydrogenation, cycloadditions, aryldiazonium salt reduction, organometallic ion attachment, carboxylation, amidation, esterification, metallic nanoparticle attachments) non-covalent methods surfactant coating, polymer wrapping, biomolecule encapsulation) enhancing CNT biocompatibility diagnostic efficiency. CNTs are extensively applied cancer through highly sensitive biosensors, including electrochemical, optical, field-effect transistor-based systems, capable detecting various biomarkers with exceptional sensitivity. Additionally, they offer advantages modalities such fluorescence imaging, magnetic resonance (MRI), computed tomography (CT), ultrasound improving contrast, resolution, specificity. also discusses challenges future directions development CNT-based platforms, emphasizing continued research advance clinical translation integration into routine diagnostics.

Язык: Английский

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