Acid-Catalyzed, Metal- and Oxidant-Free C=C Bond Cleavage of Enaminones: One-Pot Synthesis of 3,4-Dihydroquinazolines

Molecules, Год журнала: 2025, Номер 30(2), С. 350 - 350

Опубликована: Янв. 16, 2025

In this study, we present the HOAc-catalyzed selective cleavage of C=C double bond enaminones, enabling formation a new C–N and C=N for one-pot synthesis 2-substituted 3,4-dihydroquinazolines directly from ynones 2-(aminomethyl)anilines. This method operates in ethanol under transition-metal-free oxidant-free conditions, offering sustainable efficient approach with broad functional group tolerance.

Язык: Английский

An Overview of Recent Advances in Enantioselective Multicomponent Reactions

Journal of Molecular Structure, Год журнала: 2025, Номер unknown, С. 141768 - 141768

Опубликована: Фев. 1, 2025

Язык: Английский