Catalyst-Free Regio- and Stereoselective C(sp2)–H Chlorination of Enamides at Room Temperature
Min‐Zhi Deng,
M. N. SHENG,
Xueqing Wen
и другие.
Organic Letters,
Год журнала:
2025,
Номер
unknown
Опубликована: Апрель 29, 2025
We
disclose
herein
a
catalyst-free,
room-temperature
protocol
for
the
highly
regio-
and
stereoselective
alkenyl
C(sp2)-H
chlorination
of
diverse
enamides
with
commercially
available,
inexpensive
N-chlorosuccinimide
(NCS)
as
electrophilic
chlorinating
reagent
under
exceedingly
mild
conditions.
This
operationally
simple
approach
features
remarkably
broad
substrate
scope
accommodates
excellent
functional
group
tolerance,
affording
range
synthetically
valuable
geometrically
defined
β-chlorinated
in
high
yields
an
exclusive
E
configuration.
Язык: Английский
g-C3N4-Based Heterogeneous Photocatalyzed Synthesis and Evaluation of Antitumor Activities of Fluoroalkylated 4H-Pyrido[1,2-a]pyrimidin-4-ones
The Journal of Organic Chemistry,
Год журнала:
2025,
Номер
unknown
Опубликована: Фев. 26, 2025
The
first
example
of
heterogeneous
photoredox-catalyzed
fluoroalkylation
4H-pyrido[1,2-a]pyrimidin-4-ones
has
been
developed.
With
low-cost
commercial
g-C3N4
as
the
recyclable
photocatalyst
and
cheap
sodium
fluoroalkyl
sulfonates
source,
a
variety
fluoroalkylated
pyridopyrimidinones
were
constructed
in
moderate
to
high
yields.
present
reaction
can
be
easily
scaled
up
with
good
efficiency,
catalytic
system
reused
5
times
slight
loss
activities.
Furthermore,
biological
activity
synthesized
compounds
was
preliminarily
investigated.
Язык: Английский