Iron-Catalyzed Reductive Cross-Coupling of Heterocyclic Bromides
ACS Catalysis,
Год журнала:
2025,
Номер
unknown, С. 7700 - 7709
Опубликована: Апрель 24, 2025
Язык: Английский
Nickel-Catalyzed Reductive Coupling of 2-Pyridyl Esters with Unreactivated Alkyl Chlorides: A Universal Synthesis of Aryl-Alkyl and Dialkyl Ketones via Dynamic Halide Exchange
Organic & Biomolecular Chemistry,
Год журнала:
2025,
Номер
unknown
Опубликована: Янв. 1, 2025
A
Ni-catalyzed
reductive
coupling
of
2-pyridyl
esters
with
unactivated
primary
and
secondary
alkyl
chlorides
provides
direct
access
to
aryl–alkyl
dialkyl
ketones.
High
selectivity
can
be
achieved
by
rate-matching
via
dynamic
halide
exchange.
Язык: Английский
Iodide/Nickel Co-Catalyzed Manganese-Mediated Denitrogenative Cross-Electrophile Coupling of Benzotriazinones with Alkyl Sulfonates
Yingying Hong,
Xuanxuan Zhang,
Gang Zou
и другие.
Molecules,
Год журнала:
2025,
Номер
30(11), С. 2397 - 2397
Опубликована: Май 30, 2025
An
efficient
Ni-catalyzed,
Mn-mediated
denitrogenative
cross-electrophile
coupling
of
N-alkyl-1,2,3-benzotriazinones
with
alkyl
tosylates
and
mesylates
for
access
to
o-alkyl
secondary
benzamides
is
reported.
The
method
uses
inexpensive
non-anhydrous
dimethyl
acetamide
(DMA)
in
combination
tetrabutyl
ammonium
iodide
(TBAI)
as
a
co-catalyst
convert
sulfonates
into
iodides
situ.
Scope
limitations
the
protocol
have
been
demonstrated
by
>30
examples
yields
up
91%,
showing
large
electronic
effect
from
N-substituent
benzotriazinones.
unexpected
steric
acceleration
has
observed
core
benzotriazinones,
not
only
promising
highly
2-alkyl-2,3-disubstituted
but
also
shedding
light
on
rate-limiting
steps
catalytic
cycle.
Язык: Английский