Organic Letters, Год журнала: 2024, Номер 27(1), С. 340 - 345

Опубликована: Дек. 30, 2024

This work describes a chiral bifunctional squaramide/DBU sequential catalytic strategy for the enantioselective synthesis of nonfused eight-membered O-heterocycles through asymmetric addition ynones to β,γ-unsaturated α-ketoesters followed by regio- and diastereoselective cyclization adduct intermediates. Mechanistic experiments revealed that an isomerization process should be involved in ring formation step, origin high regioselectivity diastereoselectivity has also been elucidated DFT calculations.

Язык: Английский