Cross-Electrophile Coupling of Aryl Chlorides with Alkyl Chlorides Using Rotating Magnetic Field and Metal Rods
Journal of the American Chemical Society,
Год журнала:
2025,
Номер
unknown
Опубликована: Апрель 1, 2025
The
pursuit
of
sustainable
and
environmentally
benign
methods
techniques
continues
to
challenge
organic
chemists.
Herein,
we
report
the
development
a
novel
approach
in
which
electromagnetic
induction
could
participate
coupling
chlorides
using
rotating
magnetic
field
metal
rods.
In
particular,
describe
application
this
strategy
nickel-catalyzed
cross-electrophile
aryl
with
alkyl
chlorides.
Using
these
abundant
commercially
available
organochlorides,
such
system
allows
reactions
proceed
broader
scope
than
current
protocols
under
mild
conditions.
Язык: Английский
Photoinduced radical cyclization reaction of isocyanides with α-carbonyl bromides to access 11-alkyl-substituted 1,4-dibenzodiazepines
Organic & Biomolecular Chemistry,
Год журнала:
2025,
Номер
unknown
Опубликована: Янв. 1, 2025
A
photochemical
radical
cascade
cyclization
reaction
of
isocyanides
with
α-carbonyl
bromides
under
mild
conditions
is
disclosed
for
accessing
1,4-dibenzodiazepines,
demonstrating
good
tolerance
towards
various
functional
groups.
Язык: Английский
Photoinduced Metal‐/Additive‐Free Difluoromethylation of N‐Heteroaromatics†
Chinese Journal of Chemistry,
Год журнала:
2025,
Номер
unknown
Опубликована: Янв. 16, 2025
Comprehensive
Summary
Herein,
we
report
a
photo‐induced,
metal‐/additive‐free
protocol
for
the
difluoromethylation
of
N
‐heteroaromatics
with
[bis(difluoroacetoxy)iodo]benzene
as
reagent.
The
affords
difluoromethylated
in
moderate
to
good
yield
(up
91%).
transformation
is
compatible
wide
range
substrates
and
has
tolerance
towards
various
functional
groups.
Moreover,
synthetic
value
this
method
further
demonstrated
by
applications
gram‐scale
synthesis
late‐stage
functionalization
biologically
important
molecules.
Язык: Английский
Photoredox Radical Cyclization of o-Vinylaryl Isocyanides and Aryldiazonium Tetrafluoroborates for the Synthesis of 2,4-Disubstituted Quinolines
The Journal of Organic Chemistry,
Год журнала:
2025,
Номер
unknown
Опубликована: Март 23, 2025
Quinolines,
a
significant
part
of
nitrogen-containing
heterocycles,
are
widely
found
in
functional
compounds.
Herin,
photochemical
radical
cyclization
reaction
o-vinylaryl
isocyanides
and
aryldiazonium
tetrafluoroborates,
has
been
reported
to
build
2,4-diaryl
quinolines.
Readily
accessible
aryl
diazonium
salts
were
utilized
as
precursors
at
room
temperature.
This
approach
allowed
good
group
tolerance
substrate
applicability.
Язык: Английский