The Chemical Record, Год журнала: 2025, Номер unknown
Опубликована: Май 29, 2025
Macrocyclophanes are a class of macrocyclic molecules featuring aliphatic ansa chains linking non‐adjacent positions an aromatic ring, which have garnered significant attention due to their extensive applications in biological activity, pharmaceutical research, and selective optical recognition. In this review, it summarizes recent advancements the catalytic enantioselective synthesis planar‐chiral macrocyclophanes, focusing on various synthetic routes, including: a) transition‐metal‐catalyzed alkyne cyclotrimerization for planar construction; b) (dynamic) kinetic resolution achiral or prochiral macrocyclophanes; c) substitution rings; d) macrocyclization formation chains. The aim is highlight state‐of‐the‐art advances construction macrocyclophanes push field toward new horizons.
Язык: Английский