Transition metal complexes with tetradentate Schiff bases (N2O2) obtained from salicylaldehyde: A review of their possible anticancer properties

Coordination Chemistry Reviews, Год журнала: 2024, Номер 505, С. 215698 - 215698

Опубликована: Фев. 9, 2024

Язык: Английский

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Synthesis, characterization, DFT, biological activity evaluation, and molecular docking analysis of new 8-[(2-hydroxynaphthalen-1-yl)diazenyl]naphthalene-1,3-disulfonic acid based complexes

Journal of Molecular Structure, Год журнала: 2023, Номер 1300, С. 137175 - 137175

Опубликована: Ноя. 28, 2023

Язык: Английский

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Transition Metal Complexes with Tridentate Schiff Bases (O N O and O N N) Derived from Salicylaldehyde: An Analysis of Their Potential Anticancer Activity

ChemMedChem, Год журнала: 2022, Номер 17(20)

Опубликована: Сен. 7, 2022

Abstract Although it is known that the first case of cancer was recorded in ancient Egypt around 1600 BC, not until 1917 during First World War and development mustard gas chemotherapy against became relevant; however, its properties were recognised 1946 to later be used patients. In this sense, use metallopharmaceuticals therapy extensively explored 1960s with discovery cisplatin anticancer activity. From date present, search for more effective, selective metallodrugs fewer side effects has been an area continuous exploration. Efforts have led considering a wide variety metals from periodic table, mainly d ‐block, as well organic ligands, preferably proven biological various research groups found ideal binder Schiff bases, since their raw materials are easily accessible, synthesis conditions friendly denticity can manipulated. Therefore, review, we antitumor activity reported literature coordination complexes ‐block coordinated tridentate bases (O N O N) derived salicylaldehyde. For work, main scientific databases CCDC® SciFinder®.

Язык: Английский

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Evaluating the in vitro antidiabetic, antibacterial and antioxidant properties of copper(II) Schiff base complexes: An experimental and computational studies

Journal of Molecular Liquids, Год журнала: 2023, Номер 389, С. 122845 - 122845

Опубликована: Авг. 15, 2023

In recent years, metal-based compounds have been explored as potential remedies for major health issues such diabetes, bacterial infections, and oxidative stress, which impact the general well-being of humans globally. Diabetes, stress are concerns affecting millions worldwide. Researchers exploring use treatments these conditions. our quest towards identifying biologically viable compounds, three novel Cu(II) complexes were synthesized from halogen-substituted ON donor Schiff base ligands. These ligands obtained by condensing 2-hydroxybenzldehyde with different anilines. The their characterized using various spectroscopic techniques 1H 13C nuclear magnetic resonance, Fourier Transform-Infrared, Ultraviolet-visible spectra, elemental analysis, mass spectrometry, single-crystal X-ray spectroscopy to elucidate structures. screened antidiabetic (α-glucose α-amylase enzymes inhibition assay), antioxidant (2,2-diphenyl-1-picrylhydrazyl(DPPH), ferric reducing (FRAP) assay, nitric oxide(NO) radical scavenging), antimicrobial activities. pharmacological activity revealed that efficacy was enhanced upon coordination, CuL3 is more potent among complexes, having higher on α-glucosidase (IC50 = 100.1 μM) than control, whose IC50 112.4 μM same enzyme. For scavenging activity, results showed DPPH radicals control. FRAP show Similarly, NO indicate while outperformed control at all concentrations tested. vitro antibacterial some selected Gram-positive Gram-negative bacteria corresponding ligands, taking lead, showing a MIC value 4 g/mL Also, density functional theory calculations levels DFT basis sets used investigate optimized geometry, electronic structure (energy HOMO LUMO, Mulliken atomic charge, dipole moment, hardness, softness, electrophilicity, spectral properties) compounds. Molecular docking studies carried out binding affinity receptor proteins other establish mechanism action active sites.

Язык: Английский

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New Dual Inhibitors of SARS-CoV-2 Based on Metal Complexes with Schiff-Base 4-Chloro-3-Methyl Phenyl Hydrazine: Synthesis, DFT, Antibacterial Properties and Molecular Docking Studies

Inorganics, Год журнала: 2023, Номер 11(2), С. 63 - 63

Опубликована: Янв. 29, 2023

This paper explores a dual inhibition of main protease (Mpro) and nonstructural protein 10/nonstructural 16 (NSP16) methyltransferase complex as the key targets for COVID-19 therapy. These are based on new Schiff-base ligand that was obtained from condensation (4-chloro-3-methyl phenyl) hydrazine with 2-pyridine-carboxaldehyde its novel metal complexes. include Ni(II), Pd(II), Pt(II), Zn(II), Hg(II). The newly synthesized compounds have been characterized using FT-IR, 1H NMR, 13C elemental analysis. results suggested is coordinated bidentate through nitrogen atoms azomethine group pyridyl ring. In addition, biological activity prepared complexes examined against Pseudomonas aeruginosa Staphylococcus aureus, showed Zn(II) has highest compared other compounds. active sites were found by looking at molecular electrostatic potential (MEP) maps above ligands compound Ni(II) Mpro NSP10/ NSP16 investigated docking approach. They excellent binding energies ranging −5.9 to −7.2 kcal/mol −5.8 NSP16, respectively. All conformers docked site receptor, showing affinity 100%. According our knowledge, this first report these inhibitors SARS-CoV-2.

Язык: Английский

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Schiff Bases and Their Metal Complexes: Synthesis, Structural Characteristics and Applications

IntechOpen eBooks, Год журнала: 2023, Номер unknown

Опубликована: Март 2, 2023

The development of Schiff base was a major step forward in the area coordination chemistry. bases, class organic compounds, carry imine or azomethine (>C=N–) functional group. bases played an influencing role chemistry and were key point inorganic, bioinorganic optical materials. widely used organic, analytical chemistry, account for significant portion more commonly employed classes molecules. ability ligands to form stable metal complexes with wide range transition other ions makes them extremely useful. Condensation primary amine aldehyde ketone yields bases. In this chapter, we focused on introducing classified their complexes, discussed several synthesis methods, including conventional green approaches. This chapter also elaborated industries’ applications, such as food industry, agrochemical dye catalysis, energy storage, environmental, chemo-sensing, bio-sensing, biomedical applications novel complexes.

Язык: Английский

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Anticancer Activity and Mode of Action of Cu(II), Zn(II), and Mn(II) Complexes with 5-Chloro-2-N-(2-quinolylmethylene)aminophenol

Molecules, Год журнала: 2023, Номер 28(12), С. 4876 - 4876

Опубликована: Июнь 20, 2023

Developing a new generation of anticancer metal-based drugs that can both kill tumor cells and inhibit cell migration is promising strategy. Herein, we synthesized three Cu(II), Zn(II), Mn(II) complexes derived from 5-chloro-2-N-(2-quinolylmethylene)aminophenol (C1-C3). Among these complexes, the Cu(II) complex (C1) showed significantly greater cytotoxicity toward lung cancer lines than cisplatin. C1 inhibited A549 metastasis suppressed growth in vivo. In addition, confirmed mechanism by triggering multiple mechanisms, including inducing mitochondrial apoptosis, acting on DNA, blocking cycle arrest, senescence, DNA damage.

Язык: Английский

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Recent Advances in the Titanium-Based Catalysts for Ring-Opening Polymerization

ACS Omega, Год журнала: 2024, Номер 9(28), С. 29983 - 29993

Опубликована: Июль 5, 2024

At present, economic development and daily life cannot be separated from organic synthetic polymers. However, a large number of nondegradable polymers have caused serious pollution to the environment. It is necessary for sustainable use biodegradable materials instead traditional polymers, but it not yet comparable in performance cost competitor will replace. Therefore, there long way go develop effective synthesis methods. Through ring-opening polymerization, some cyclic monomers, such as ε-caprolactone or lactide, can synthesized into which only replace fields also applications drug delivery, surgical consumables, human implant materials, bone etc. Ring-opening polymerization potential candidate solving environmental pollution. For catalysts are very important, among titanium attracted much attention because their high efficiency, economy, nontoxicity. In this paper, status organotitanium compounds reviewed, including effects different ligand structures on behavior polymer structure, its trend prospected. We hope that review helpful developing efficient catalysts.

Язык: Английский

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Recent advances of Schiff base metal complexes as potential anticancer agents

Coordination Chemistry Reviews, Год журнала: 2024, Номер 525, С. 216327 - 216327

Опубликована: Ноя. 20, 2024

Язык: Английский

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Tetrelanes versus Tetrylenes as Precursors to Transition Metal Complexes Featuring Tridentate PEP Tetryl Ligands (E=Si, Ge, Sn)

Chemistry - A European Journal, Год журнала: 2022, Номер 29(18)

Опубликована: Дек. 2, 2022

Abstract Two synthetic approaches have until now been used to synthesize transition metal complexes having a tridentate (pincer or tripod) PEP tetryl (E=Si, Ge, Sn) ligand. These differ in the metal‐free precursor, tetrelane tetrylene, that gives rise corresponding Tetrelanes (PSiP silanes, PGeP germanes and PSnP stannanes simple phosphane‐free stannanes) led ligands by oxidatively adding an E−X bond (X=H, C halogen most cases) atom of low‐valent complex, whereas tetrylenes (PGeP germylenes stannylenes) upon insertion their E into M−X (X=Cl precursor through derivatization after tetrylene fragment is coordinated metal. For each approach, all currently known types ligand frameworks found are presented discussed this review.

Язык: Английский

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