Applied Organometallic Chemistry,
Год журнала:
2024,
Номер
38(7)
Опубликована: Май 23, 2024
Two
new
Schiff‐base
bismuth
(III)
complexes
were
prepared
by
an
equivalent
reaction
between
ligand
and
Bi
(NO
3
)
•5H
2
O
with
the
assistance
of
Mannitol.
The
chemical
structures
two
characterized
spectroscopic
studies
(FT‐IR,
NMR,
MS),
elemental
analysis,
single‐crystal
X‐ray
diffraction.
ligand‐to‐metal
ion
ratio
was
found
to
be
1:1
in
complexes.
During
formation
complexes,
Schiff
bases
changed
from
amidic
forms
iminol
forms,
resulting
tautomers
could
coordinate
ions
produce
dinuclear
III
complexes(
1a
2a
).
Structural
analyses
showed
that
each
held
a
distorted
capped
octahedron
geometry
seven‐coordinate
mode
Screening
vitro
biological
activities
revealed
exhibited
much
higher
antimicrobial
cytotoxic
activity
than
their
parent
ligands.
complex(
close
known
anticancer
drug
(Doxorubicin)
evaluating
against
SGC7901
cells,
IC
50
value
0.59
μM.
effectively
induce
cell
apoptosis
its
oral
acute
toxicity
for
LD50
576
mg
kg
−1
.
content
mitochondria
nucleus.
Abstract
Although
it
is
known
that
the
first
case
of
cancer
was
recorded
in
ancient
Egypt
around
1600
BC,
not
until
1917
during
First
World
War
and
development
mustard
gas
chemotherapy
against
became
relevant;
however,
its
properties
were
recognised
1946
to
later
be
used
patients.
In
this
sense,
use
metallopharmaceuticals
therapy
extensively
explored
1960s
with
discovery
cisplatin
anticancer
activity.
From
date
present,
search
for
more
effective,
selective
metallodrugs
fewer
side
effects
has
been
an
area
continuous
exploration.
Efforts
have
led
considering
a
wide
variety
metals
from
periodic
table,
mainly
d
‐block,
as
well
organic
ligands,
preferably
proven
biological
various
research
groups
found
ideal
binder
Schiff
bases,
since
their
raw
materials
are
easily
accessible,
synthesis
conditions
friendly
denticity
can
manipulated.
Therefore,
review,
we
antitumor
activity
reported
literature
coordination
complexes
‐block
coordinated
tridentate
bases
(O
N
O
N)
derived
salicylaldehyde.
For
work,
main
scientific
databases
CCDC®
SciFinder®.
Journal of Molecular Liquids,
Год журнала:
2023,
Номер
389, С. 122845 - 122845
Опубликована: Авг. 15, 2023
In
recent
years,
metal-based
compounds
have
been
explored
as
potential
remedies
for
major
health
issues
such
diabetes,
bacterial
infections,
and
oxidative
stress,
which
impact
the
general
well-being
of
humans
globally.
Diabetes,
stress
are
concerns
affecting
millions
worldwide.
Researchers
exploring
use
treatments
these
conditions.
our
quest
towards
identifying
biologically
viable
compounds,
three
novel
Cu(II)
complexes
were
synthesized
from
halogen-substituted
ON
donor
Schiff
base
ligands.
These
ligands
obtained
by
condensing
2-hydroxybenzldehyde
with
different
anilines.
The
their
characterized
using
various
spectroscopic
techniques
1H
13C
nuclear
magnetic
resonance,
Fourier
Transform-Infrared,
Ultraviolet-visible
spectra,
elemental
analysis,
mass
spectrometry,
single-crystal
X-ray
spectroscopy
to
elucidate
structures.
screened
antidiabetic
(α-glucose
α-amylase
enzymes
inhibition
assay),
antioxidant
(2,2-diphenyl-1-picrylhydrazyl(DPPH),
ferric
reducing
(FRAP)
assay,
nitric
oxide(NO)
radical
scavenging),
antimicrobial
activities.
pharmacological
activity
revealed
that
efficacy
was
enhanced
upon
coordination,
CuL3
is
more
potent
among
complexes,
having
higher
on
α-glucosidase
(IC50
=
100.1
μM)
than
control,
whose
IC50
112.4
μM
same
enzyme.
For
scavenging
activity,
results
showed
DPPH
radicals
control.
FRAP
show
Similarly,
NO
indicate
while
outperformed
control
at
all
concentrations
tested.
vitro
antibacterial
some
selected
Gram-positive
Gram-negative
bacteria
corresponding
ligands,
taking
lead,
showing
a
MIC
value
4
g/mL
Also,
density
functional
theory
calculations
levels
DFT
basis
sets
used
investigate
optimized
geometry,
electronic
structure
(energy
HOMO
LUMO,
Mulliken
atomic
charge,
dipole
moment,
hardness,
softness,
electrophilicity,
spectral
properties)
compounds.
Molecular
docking
studies
carried
out
binding
affinity
receptor
proteins
other
establish
mechanism
action
active
sites.
Inorganics,
Год журнала:
2023,
Номер
11(2), С. 63 - 63
Опубликована: Янв. 29, 2023
This
paper
explores
a
dual
inhibition
of
main
protease
(Mpro)
and
nonstructural
protein
10/nonstructural
16
(NSP16)
methyltransferase
complex
as
the
key
targets
for
COVID-19
therapy.
These
are
based
on
new
Schiff-base
ligand
that
was
obtained
from
condensation
(4-chloro-3-methyl
phenyl)
hydrazine
with
2-pyridine-carboxaldehyde
its
novel
metal
complexes.
include
Ni(II),
Pd(II),
Pt(II),
Zn(II),
Hg(II).
The
newly
synthesized
compounds
have
been
characterized
using
FT-IR,
1H
NMR,
13C
elemental
analysis.
results
suggested
is
coordinated
bidentate
through
nitrogen
atoms
azomethine
group
pyridyl
ring.
In
addition,
biological
activity
prepared
complexes
examined
against
Pseudomonas
aeruginosa
Staphylococcus
aureus,
showed
Zn(II)
has
highest
compared
other
compounds.
active
sites
were
found
by
looking
at
molecular
electrostatic
potential
(MEP)
maps
above
ligands
compound
Ni(II)
Mpro
NSP10/
NSP16
investigated
docking
approach.
They
excellent
binding
energies
ranging
−5.9
to
−7.2
kcal/mol
−5.8
NSP16,
respectively.
All
conformers
docked
site
receptor,
showing
affinity
100%.
According
our
knowledge,
this
first
report
these
inhibitors
SARS-CoV-2.
IntechOpen eBooks,
Год журнала:
2023,
Номер
unknown
Опубликована: Март 2, 2023
The
development
of
Schiff
base
was
a
major
step
forward
in
the
area
coordination
chemistry.
bases,
class
organic
compounds,
carry
imine
or
azomethine
(>C=N–)
functional
group.
bases
played
an
influencing
role
chemistry
and
were
key
point
inorganic,
bioinorganic
optical
materials.
widely
used
organic,
analytical
chemistry,
account
for
significant
portion
more
commonly
employed
classes
molecules.
ability
ligands
to
form
stable
metal
complexes
with
wide
range
transition
other
ions
makes
them
extremely
useful.
Condensation
primary
amine
aldehyde
ketone
yields
bases.
In
this
chapter,
we
focused
on
introducing
classified
their
complexes,
discussed
several
synthesis
methods,
including
conventional
green
approaches.
This
chapter
also
elaborated
industries’
applications,
such
as
food
industry,
agrochemical
dye
catalysis,
energy
storage,
environmental,
chemo-sensing,
bio-sensing,
biomedical
applications
novel
complexes.
Molecules,
Год журнала:
2023,
Номер
28(12), С. 4876 - 4876
Опубликована: Июнь 20, 2023
Developing
a
new
generation
of
anticancer
metal-based
drugs
that
can
both
kill
tumor
cells
and
inhibit
cell
migration
is
promising
strategy.
Herein,
we
synthesized
three
Cu(II),
Zn(II),
Mn(II)
complexes
derived
from
5-chloro-2-N-(2-quinolylmethylene)aminophenol
(C1-C3).
Among
these
complexes,
the
Cu(II)
complex
(C1)
showed
significantly
greater
cytotoxicity
toward
lung
cancer
lines
than
cisplatin.
C1
inhibited
A549
metastasis
suppressed
growth
in
vivo.
In
addition,
confirmed
mechanism
by
triggering
multiple
mechanisms,
including
inducing
mitochondrial
apoptosis,
acting
on
DNA,
blocking
cycle
arrest,
senescence,
DNA
damage.
ACS Omega,
Год журнала:
2024,
Номер
9(28), С. 29983 - 29993
Опубликована: Июль 5, 2024
At
present,
economic
development
and
daily
life
cannot
be
separated
from
organic
synthetic
polymers.
However,
a
large
number
of
nondegradable
polymers
have
caused
serious
pollution
to
the
environment.
It
is
necessary
for
sustainable
use
biodegradable
materials
instead
traditional
polymers,
but
it
not
yet
comparable
in
performance
cost
competitor
will
replace.
Therefore,
there
long
way
go
develop
effective
synthesis
methods.
Through
ring-opening
polymerization,
some
cyclic
monomers,
such
as
ε-caprolactone
or
lactide,
can
synthesized
into
which
only
replace
fields
also
applications
drug
delivery,
surgical
consumables,
human
implant
materials,
bone
etc.
Ring-opening
polymerization
potential
candidate
solving
environmental
pollution.
For
catalysts
are
very
important,
among
titanium
attracted
much
attention
because
their
high
efficiency,
economy,
nontoxicity.
In
this
paper,
status
organotitanium
compounds
reviewed,
including
effects
different
ligand
structures
on
behavior
polymer
structure,
its
trend
prospected.
We
hope
that
review
helpful
developing
efficient
catalysts.
Chemistry - A European Journal,
Год журнала:
2022,
Номер
29(18)
Опубликована: Дек. 2, 2022
Abstract
Two
synthetic
approaches
have
until
now
been
used
to
synthesize
transition
metal
complexes
having
a
tridentate
(pincer
or
tripod)
PEP
tetryl
(E=Si,
Ge,
Sn)
ligand.
These
differ
in
the
metal‐free
precursor,
tetrelane
tetrylene,
that
gives
rise
corresponding
Tetrelanes
(PSiP
silanes,
PGeP
germanes
and
PSnP
stannanes
simple
phosphane‐free
stannanes)
led
ligands
by
oxidatively
adding
an
E−X
bond
(X=H,
C
halogen
most
cases)
atom
of
low‐valent
complex,
whereas
tetrylenes
(PGeP
germylenes
stannylenes)
upon
insertion
their
E
into
M−X
(X=Cl
precursor
through
derivatization
after
tetrylene
fragment
is
coordinated
metal.
For
each
approach,
all
currently
known
types
ligand
frameworks
found
are
presented
discussed
this
review.