Sesquiterpene Lactones as Promising Anti-Glioblastoma Drug Candidates Exerting Complex Effects on Glioblastoma Cell Viability and Proneural–Mesenchymal Transition
Biomedicines,
Год журнала:
2025,
Номер
13(1), С. 133 - 133
Опубликована: Янв. 8, 2025
Glioblastoma
is
one
of
the
most
aggressive
brain
cancers,
characterized
by
active
infiltrative
growth
and
high
resistance
to
radiotherapy
chemotherapy.
Sesquiterpene
triterpenoids
(STLs)
their
semi-synthetic
analogs
are
considered
as
a
promising
source
novel
anti-tumor
agents
due
low
systemic
toxicity
multi-target
pharmacological
effects
on
key
processes
associated
with
tumor
progression.
The
current
review
aims
systematize
knowledge
anti-glioblastoma
potential
STLs
accumulated
over
last
decade
identify
in
glioblastoma
cells
that
susceptible
action
STLs.
An
analysis
published
data
clearly
demonstrated
STLs,
which
can
successfully
cross
blood-brain
barrier,
exert
complex
inhibitory
effect
through
induction
"mitochondrial
dysfunction-oxidative
stress-apoptosis"
axis,
inhibition
glucose
metabolism
cell
cycle
phase
transition,
suppression
motility
invasion
blockade
proneural-mesenchymal
transition.
Taken
together,
this
highlights
not
only
able
induce
death,
but
also
effectively
affect
diffusive
spread,
suggests
possible
directions
for
further
investigation
context
better
understand
mechanism
action.
Язык: Английский
Exploring Sesquiterpene Lactones from Saussurea lappa: Isolation, Structural Modifications, and Herbicide Bioassay Evaluation
Plants,
Год журнала:
2025,
Номер
14(7), С. 1111 - 1111
Опубликована: Апрель 2, 2025
Considering
the
resistance
of
weeds
to
different
herbicides
with
mechanisms
action,
search
for
new,
more
selective
compounds
low
toxicity
other
species
in
nature
has
been
very
important
development
agriculture.
Because
that,
considering
biological
activity
allelochemicals
and
natural
epoxides,
four
new
epoxy
derived
from
dehydrocostus
lactone
were
synthetized
evaluated
their
potential
herbicide
against
three
seeds,
Allium
cepa
(onion),
Lepidium
sativum
(garden
cress),
Lactuca
sativa
(lettuce).
In
assays
A.
cepa,
compound
4
inhibited
radicle
length
by
80%
at
100
μM.
Notably,
L.
sativum,
showed
significant
inhibition,
reducing
stalk
lengths
μM,
surpassing
performance
commercial
Logran.
However,
diol
5
notably
growth
28%
making
most
observed
effect.
One
noteworthy
lactones
studied
is
epoxide
4.
This
highlights
importance
functional
group
affecting
both
shoot
seeds.
Therefore,
synthesis
these
proven
advantageous
holds
great
herbicides.
Язык: Английский