Investigation of photophysical properties and potential biological applications of substituted tris(polypyridyl)ruthenium(II) complexes

Frontiers in Chemistry, Год журнала: 2025, Номер 13

Опубликована: Фев. 3, 2025

The photophysical properties of tris(polypyridyl)ruthenium(II) complex [Ru(dmbpy) 3 ] 2+ [dmbpy = 4,4′-dimethyl-2,2′-bipyridine] were investigated and compared with [Ru(bpy) following both experimental computational approaches. variations in the electronic ground excited states determined by density functional theory (DFT) methods, their effects on anticancer, antioxidant, antimicrobial activities also evaluated molecular docking dynamic simulation studies. potential these complexes to serve as bioanalytes was ability bind quinones, well-known electron mediators numerous light-driven reactions. Following above, anticancer against breast cancer-related proteins. results revealed that possesses comparable antioxidant . physical, electronic, biological this depend nature ligands medium investigation. Herein, applications clinical diagnostics antioxidants therapeutic agents evaluated.

Язык: Английский

Supramolecular approaches for the treatment of hypoxic regions in tumours

Nature Reviews Chemistry, Год журнала: 2025, Номер unknown

Опубликована: Апрель 4, 2025

Язык: Английский