Journal of Controlled Release, Год журнала: 2025, Номер unknown, С. 113906 - 113906
Опубликована: Июнь 1, 2025
Язык: Английский
ACS Nano, Год журнала: 2024, Номер 18(42), С. 29045 - 29058
Опубликована: Окт. 11, 2024
Lipid nanoparticles (LNPs) have emerged as an effective and promising technology for messenger RNA (mRNA) delivery, offering a potential solution to physiological barriers providing alternative approach gene therapy without the drawbacks associated with viral delivery. However, efficiently delivering mRNA remains significant challenge in nucleic acid-based therapies due limitations of current LNP platforms achieving optimal endosomal escape release, which largely relies on finding suitable ionizable lipid. Additionally, synthesis these lipids involves multiple chemical reactions, often making process time-consuming difficult translate. In this study, we employed facile, catalyst-free, versatile one-pot multicomponent reaction (MCR) develop library featuring pharmacologically tetrahydropyrimidine (THP) backbone, tailored enhanced A 26 THP was systematically synthesized just 3 h formulated luciferase initial
Язык: Английский
Процитировано
3
NPG Asia Materials, Год журнала: 2025, Номер 17(1)
Опубликована: Апрель 4, 2025
Язык: Английский
Процитировано
0
Small Science, Год журнала: 2025, Номер unknown
Опубликована: Апрель 11, 2025
Cancer is a daunting global health problem with steadily rising incidence. Despite the wide arsenal of current anticancer therapies, challenges such as drug resistance, tumor heterogeneity, poor targeting, and severe side effects often lead to suboptimal efficacy patient outcomes, highlighting need for innovative therapies. Autophagy modulation has emerged an attractive approach complement existing The dual role autophagy in cancer promotion suppression inspired development new drugs therapeutic strategies focusing on both inhibition induction. promising results modulators preclinical studies, lack selectivity potency, toxicity, pharmacokinetics, inadequate targeting continue limit their successful clinical translation. Many these could be overcome using nanomedicine. This review explores recent advancements nanomedicine modulation. Successful combination leveraging nanoparticles synergy chemotherapy, immunotherapy, phototherapy, gene therapy, other modalities are presented. Additionally, nanomaterials intrinsic autophagy‐modulating capabilities, self‐assembling inhibitors, discussed. Finally, limitations currently trials discussed, future perspectives designing implementation explored.
Язык: Английский
Процитировано
0
Biomaterials, Год журнала: 2025, Номер unknown, С. 123421 - 123421
Опубликована: Май 1, 2025
Язык: Английский
Процитировано
0
Small Methods, Год журнала: 2025, Номер unknown
Опубликована: Май 28, 2025
Abstract Gene editing has emerged as a promising therapeutic option for treating genetic diseases. However, central challenge in the field is safe and efficient delivery of these large tools, especially vivo. Lipid nanoparticles (LNPs) are attractive nonviral vectors due to their low immunogenicity high efficiency. To maximize efficiency, LNPs should efficiently protect gene components against multiple biological barriers release them into cytoplasm target cells. In this review, widely used CRISPR systems first overviewed. Then, each component LNPs, well effects on delivery, systematically discussed. Following this, current LNP engineering strategies achieve non‐liver targeting summarized. Finally, preclinical clinical applications vivo genome highlighted, perspectives future development provided.
Язык: Английский
Процитировано
0
Journal of Controlled Release, Год журнала: 2025, Номер unknown, С. 113906 - 113906
Опубликована: Июнь 1, 2025
Язык: Английский
Процитировано
0