MedMat., Год журнала: 2024, Номер 1(2), С. 74 - 94

Опубликована: Дек. 1, 2024

Cuproptosis, a newly discovered copper-dependent mode of cell death, has received extensive attention in the field cancer therapy due to its specific activation pathway. Rapid accumulation large amounts copper ions within cells achieve overload is key activating cuproptosis. Advanced nanotechnology offers considerable promise for delivering cells, which copper-based nanomaterials have been proposed evoke cuproptosis-mediated therapy. However, it still great challenge induce specifically tumors and efficiently activate subsequent cuproptosis-related molecular pathways. Therefore, necessary summarize strategies used effectively or amplify cuproptosis based on currently developed nanomaterials, providing ideas design future. In this review, that can be are systematically classified selection. Subsequently, sensitization using provided therapeutic efficiency. Meanwhile, combination therapies maximizing treatment efficacy delineated. Ultimately, remaining challenges feasible future directions use tumor also discussed.

Язык: Английский