Botanical Flavonoids: Efficacy, Absorption, Metabolism and Advanced Pharmaceutical Technology for Improving Bioavailability
Molecules,
Год журнала:
2025,
Номер
30(5), С. 1184 - 1184
Опубликована: Март 6, 2025
Flavonoids
represent
a
class
of
natural
plant
secondary
metabolites
with
multiple
activities
including
antioxidant,
antitumor,
anti-inflammatory,
and
antimicrobial
properties.
However,
due
to
their
structural
characteristics,
they
often
exhibit
low
bioavailability
in
vivo.
In
this
review,
we
focus
on
the
vivo
study
flavonoids,
particularly
effects
gut
microbiome
common
modifications
such
as
methylation,
acetylation,
dehydroxylation,
etc.
These
aim
change
characteristics
original
substances
enhance
absorption
bioavailability.
order
improve
discuss
two
feasible
methods,
namely
dosage
form
modification
chemical
modification,
hope
that
these
approaches
will
offer
new
insights
into
application
flavonoids
for
human
health.
article,
also
introduce
types,
sources,
efficacy
flavonoids.
conclusion,
is
comprehensive
review
how
Язык: Английский
Phytosomes as a New Frontier and Emerging Nanotechnology Platform for Phytopharmaceuticals: Therapeutic and Clinical Applications
Phytotherapy Research,
Год журнала:
2025,
Номер
unknown
Опубликована: Март 20, 2025
ABSTRACT
A
complete
investigation
into
phytosome‐based
formulations
and
innovative
nanotechnology
is
presented
in
this
review.
This
aims
to
improve
the
bioavailability
therapeutic
effectiveness
of
herbal
components.
Phytosomes
can
significantly
increase
solubility,
absorption,
stability
compared
standard
by
encapsulating
active
phytoconstituents
phospholipid
complexes.
unique
ability
phytosomes
overcome
limits
traditional
a
potential
game
changer
medicine.
study
highlights
different
uses
across
various
health
disorders,
such
as
neurodegenerative
illnesses,
inflammatory
conditions,
diabetes,
cardiovascular
diseases,
wound
healing.
The
review
also
discusses
treating
infectious
diseases
improving
delivery
bioactive
compounds
that
have
improved
anticancer
efficacy
antibacterial
properties.
Despite
emergence
numerous
groundbreaking
discoveries,
substantial
barriers
remain
hinder
their
widespread
application.
Challenges
must
be
addressed
include
stability,
large‐scale
manufacture,
regulatory
hurdles,
limited
clinical
translation.
examines
limitations
present
practice,
mainly
focusing
on
variability
bioavailability.
crucial
need
for
future
research
phytosomes,
engaging
researchers
emphasizing
continuous
evolution
promising
area
Язык: Английский
Efficient Consecutive Synthesis of Fluorinated Isoflavone Analogs, X-Ray Structures, Hirshfeld Analysis, and Anticancer Activity Assessment
Molecules,
Год журнала:
2025,
Номер
30(4), С. 795 - 795
Опубликована: Фев. 9, 2025
The
synthesis
of
7-O-carboxymethyl-4'-fluoroisoflavone
4
and
7-O-carboxymethyl-4'-fluoro-2-trifluormethylisoflavone
7
involved
the
cyclization
2,4-dihydroxy-4'-fluorodeoxybenzoin
1,
followed
by
7-O-alkylation
with
methyl
bromoacetate
subsequent
acid-catalyzed
hydrolysis.
structures
novel
compounds
were
validated
using
a
range
techniques,
including
XRD
crystallography
(1H,
19F,
13C)-NMR,
IR.
Only
interhalogen
contacts
detected
in
5,
while
they
completely
lacking
2
4,
owing
to
presence
crystalline
ethanol
crystal
structure.
%F…F
5
was
12.2%
based
on
Hirshfeld
calculations.
aromatic
π-π
stacking
interactions
important
only
but
not
observed
5.
Isoflavones
displayed
anticancer
activity
against
MCF-7
cancer
cells,
IC50
values
13.66,
15.43,
11.73
µM,
respectively.
Язык: Английский