Longitudinal economic burden of incident complications among metabolic syndrome populations

Cardiovascular Diabetology, Год журнала: 2024, Номер 23(1)

Опубликована: Июль 10, 2024

Abstract Background This study quantifies the longitudinal economic burden for a wide spectrum of incident complications, metabolic syndrome (MS)-related risk factors, and comorbidities in patients with MS. Methods retrospective utilized linked data from 2013 National Health Interview Survey 2012–2021 Insurance Research Database to identify MS individuals their characteristics. The incidence rate each complication was calculated as number events period divided by total person-years during follow-up. healthcare costs complications were analyzed using generalized estimating equation model determine cost impact after adjustment patients’ Sensitivity analyses on variables high missing rates (i.e., cause death, body mass index) performed. Results Among 837 identified over 8.28 (± 1.35) years follow-up, most frequent microvascular diseases (incidence nephropathy/retinopathy/neuropathy: 6.49/2.64/2.08 per 100 person-years), followed cardiovascular (2.47), peripheral vascular (2.01), cancers (1.53). Death costliest event (event-year person: USD 16,429) expensive (USD 9,127−11,083 non-MS- MS-related cancers). Developing non-MS/MS-related cancers, diseases, obesity-related medical conditions increased annual 273% (95% CI: 181−397%)/175% (105−269%), 159% (118−207%), 140% (84−214%), respectively. Microvascular had lowest 27% [17−39%]/27% [11−46%]/24% [11−37%] increases nephropathy/neuropathy/retinopathy, respectively). Having existing 20% (osteoarthritis) 108% (depression). morbid obesity index ≥ 35 kg/m 2 ) 58% (30−91%). Conclusions costly cancers), factors obesity), depression) highlight urgent need early intervention prevent its progression. comprehensive estimates reported this can facilitate parameterization cost-effective interventions these patients.

Язык: Английский

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Link Between Metabolic Syndrome, Inflammation, and Eye Diseases

International Journal of Molecular Sciences, Год журнала: 2025, Номер 26(5), С. 2174 - 2174

Опубликована: Фев. 28, 2025

Metabolic syndrome (MetS)-a cluster of conditions including obesity, hypertension, dyslipidemia, and insulin resistance-is increasingly recognized as a key risk factor for the development various eye diseases. The metabolic dysfunctions associated with this contribute to vascular neurodegenerative damage within eye, influencing disease onset progression. Understanding these links highlights importance early diagnosis management prevent vision loss improve ocular health outcomes. This review explores intricate interplay between syndrome, chronic low-grade inflammation, diseases such diabetic retinopathy, age-related macular degeneration, glaucoma, dry syndrome. It how inflammatory mediators, oxidative damage, dysregulation converge compromise structures, retina, optic nerve, surface. We discuss molecular cellular mechanisms underpinning associations examine evidence from clinical experimental studies. Given rising global prevalence addressing connection is crucial improving overall patient outcomes quality life. Future research should focus on delineating precise linking well exploring targeted interventions that address both health.

Язык: Английский

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Insights Into Heart-Tumor Interactions in Heart Failure

Circulation Research, Год журнала: 2025, Номер 136(11), С. 1262 - 1285

Опубликована: Май 22, 2025

Heart failure (HF) often coexists with cancer. Beyond the known cardiotoxicity of some cancer treatments, HF itself has been associated increased incidence. The 2 conditions share common risk factors, mechanisms, and interactions that can worsen patient outcomes. bidirectional relationship between presents a complex interplay factors are not fully understood. Recent preclinical evidence suggests may promote tumor growth via release protumorigenic from injured heart, revealing as potentially condition. Our review discusses biological crosstalk cancer, emphasizing impact on growth, inflammation, modulating immune system central mechanisms. We further explore clinical implications this connection propose future research directions. Understanding mechanistic overlap could lead to new biomarkers therapies, addressing growing prevalence both enhancing approaches diagnosis, prevention, treatment.

Язык: Английский

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The association of life’s essential 8 scores trajectory patterns with the risk of all cancer types

Scientific Reports, Год журнала: 2025, Номер 15(1)

Опубликована: Март 20, 2025

The "Life's Essential 8" (LE8) is a comprehensive lifestyle assessment tool by the American Heart Association, designed to mitigate cardiovascular disease risk optimizing factors including diet, physical activity, and other health metrics. While individual components of LE8 have been linked reduced cancer risks, studies on score trajectories over time their relation are lacking. This study employed Kailuan cohort, involving 48,330 participants who underwent three examinations from 2006 2010 determine scores. were analyzed using latent mixture modeling, association with incident risks was assessed through Cox proportional hazard models, adjusting for confounders such as age, biological sex, behaviors. Three distinct trajectory patterns identified: low-stable (21.2%), moderate-stable (49.4%), elevated-stable (29.4%). Participants showed 21% (HR = 0.79; 95% CI: 0.70–0.90), 27% 0.73, 0.57–0.92), 51% 0.49, 0.32–0.77), 31% 0.69, 0.50–0.97) 39% 0.61, 0.39–0.95) reduction in overall, lung, breast, colorectal liver compared those Notably, protective effect scores against breast pronounced elevated CRP levels, indicating an interaction between inflammation trajectories. Maintaining high stable significantly associated risk, underscoring importance integrating into public clinical strategies prevention. study, ChiCTR–TNRC–11,001,489. Registered August 24, 2011-Retrospectively registered, http://www.chictr.org.cn/showprojen.aspx?proj=8050 .

Язык: Английский

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The Metabolic Syndrome During Female Midlife and Beyond

Опубликована: Янв. 1, 2025

Язык: Английский

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The multifaceted role of agents counteracting metabolic syndrome: A new hope for gastrointestinal cancer therapy

Pharmacology & Therapeutics, Год журнала: 2025, Номер unknown, С. 108847 - 108847

Опубликована: Апрель 1, 2025

Язык: Английский

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Metabolic Syndrome and Liver Disease: Re-Appraisal of Screening, Diagnosis, and Treatment Through the Paradigm Shift from NAFLD to MASLD

Journal of Clinical Medicine, Год журнала: 2025, Номер 14(8), С. 2750 - 2750

Опубликована: Апрель 16, 2025

Metabolic dysfunction-associated steatotic liver disease (MASLD), previously known as non-alcoholic fatty (NAFLD), encompasses a spectrum of diseases characterized by hepatic steatosis, the presence at least one cardiometabolic risk factor, and no other apparent cause. syndrome (MetS) is cluster clinical conditions associated with increased cardiovascular disease, type 2 diabetes, overall morbidity mortality. This narrative review summarizes changes in management people MetS NAFLD/MASLD from screening to therapeutic strategies that have occurred last decades. Specifically, we underline importance considering different impacts simple steatosis advanced fibrosis provide an up-to-date overview on non-invasive diagnostic tests (i.e., imaging serum biomarkers), which now offer acceptable accuracy are globally more accessible. Early detection MASLD top priority it allows for timely interventions, primarily through lifestyle modification. The benefits global multidimensional approach not negligible. Therefore, holistic both conditions, related chronic should be applied improve health longevity.

Язык: Английский

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The prevalence of metabolic syndrome and the associated factors in a multiethnic upper-middle-income country in Asia: findings from a nationwide community-based study in 2023

BMC Public Health, Год журнала: 2025, Номер 25(1)

Опубликована: Апрель 22, 2025

Язык: Английский

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Extra-nuclear and cytoplasmic steroid receptor signalling in hormone dependent cancers

The Journal of Steroid Biochemistry and Molecular Biology, Год журнала: 2024, Номер 243, С. 106559 - 106559

Опубликована: Май 31, 2024

Steroid hormone receptors are key mediators in the execution of action through a combination genomic and non-genomic action. Since their isolation characterisation early 20th Century much our understanding biological actions steroid hormones underpinned by activated receptor activity. Over past two decades there has been an acceleration more omics-based research which resulted major uptick comprehension However, it is well understood that can induce very rapid signalling events tandem with wherein they exert influence alterations gene expression. Thus totality occurs simultaneous reciprocal manner greater appreciation whole cell required to fully evaluate activity vivo. In this mini-review we outline most recent developments cytoplasmic biology endocrine-related cancers focus on 3-keto receptors, particular androgen receptor.

Язык: Английский

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Association of the Number of Concurrent Metabolic Syndrome Risk Factors with Textbook Outcomes Following Liver Resection for Patients with Hepatocellular Carcinoma: A Multicenter Study

Annals of Surgical Oncology, Год журнала: 2024, Номер unknown

Опубликована: Окт. 7, 2024

Язык: Английский

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