Serum urea concentration and risk of 16 site-specific cancers, overall cancer, and cancer mortality in individuals with metabolic syndrome: a cohort study

BMC Medicine, Год журнала: 2024, Номер 22(1)

Опубликована: Ноя. 15, 2024

The relationship between serum urea concentration and cancer in patients with metabolic syndrome (MetS) remains unclear. This study aimed to investigate the association 16 site-specific cancers, overall incidence, mortality individuals MetS. We analysed data of 108,284 MetS obtained from UK Biobank. Cox proportional hazards model was used determine at recruitment cancer. Benjamini–Hochberg correction account for multiple comparisons. Over median follow-up period 11.86 years, 18,548 new incident cases were documented. There inverse associations incidence oesophageal lung respective hazard ratios (95% confidence intervals) [HR CI)] highest (Q4) vs lowest (Q1) quartiles 0.95 (0.91–0.99), 0.68 (0.50–0.92), 0.76 (0.64–0.90). However, high concentrations increased male prostate risk (HR 1.15; 95% CI 1.02–1.30). Although indicated a protective effect higher levels against stomach 0.67; 0.45–0.98; p = 0.040; FDR 0.120) colorectal 0.86; 0.74–0.99; 0.048; 0.123), no strong evidence found after applying Benjamin-Hochberg correction. Moreover, across 13.77 years outcome, 5034 deaths detected. An "L-shaped" nonlinear dose–response discovered (p-nonlinear < 0.001), HR CI) Q4 Q1 0.83 (0.77–0.91). Serum can be considered as valuable biomarker evaluating MetS, potentially contributing personalised screening management strategies.

Язык: Английский

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Liver Allograft Cirrhosis, Retransplant, and Mortality Secondary to Recurrent Disease After Transplant for MASH: A Systematic Review and Meta-analysis

Transplantation, Год журнала: 2024, Номер unknown

Опубликована: Дек. 11, 2024

Recurrent disease after liver transplant is well recognized for many diseases. Metabolic dysfunction-associated steatotic (MASLD) and steatohepatitis (MASH) are leading indications transplant, there scarce knowledge about recurrence-related end outcomes such as retransplant mortality. This project aims to assess the proportion of patients transplanted MASH who develop recurrent adverse clinical outcomes.

Язык: Английский

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Metabolic syndrome is associated with mortality in elderly patients with acute respiratory distress syndrome

Diabetology & Metabolic Syndrome, Год журнала: 2024, Номер 16(1)

Опубликована: Авг. 8, 2024

This study aims to evaluate the association of metabolic syndrome (MetS) with risk all-cause mortality in elderly patients acute respiratory distress (ARDS).

Язык: Английский

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Risk of Incident Cancer in Veterans with Diabetes Who Use Metformin Versus Sulfonylureas

Journal of Cancer Prevention, Год журнала: 2024, Номер 29(4), С. 140 - 147

Опубликована: Дек. 30, 2024

Maya M. Abdallah, Beatriz Desanti de Oliveira, Clark DuMontier, Ariela R. Orkaby, Lisa Nussbaum, Michael Gaziano, Luc Djousse, David Gagnon, Kelly Cho, Sarah Preis, Jane A. Driver. J Cancer Prev 2024;29:140-7. https://doi.org/10.15430/JCP.24.012

Язык: Английский

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