Cerebral Cortical Vasodilation via Nicotinic Receptors by Heated Tobacco Product Aerosol Extract in Rats DOI Creative Commons
Sae Uchida,

Jura Moriya,

Daichi Morihara

и другие.

Journal of Vascular Research, Год журнала: 2024, Номер unknown, С. 1 - 9

Опубликована: Ноя. 5, 2024

Introduction: Smoking increases the risk of lung cancer due to a number components smoke. The use novel heated tobacco products (HTPs), alternative conventional combustion cigarettes, has increased in recent years. However, vivo biological effects HTPs are poorly understood. This study aimed clarify acute injecting aerosol extract prepared from an HTP on regional cerebral blood flow (rCBF) rat cortex by comparing them smoke combustible cigarettes. Methods: In urethane anesthetized rats, rCBF was measured using laser speckle contrast imaging simultaneously with arterial pressure. Results: Both cigarette and extract, at dose equivalent 30 μg nicotine/kg, injected intravenously, cortical without changing magnitude time course response both extracts were similar throughout area, all abolished dihydro-β-erythroidine, α4β2-preferring nicotinic acetylcholine receptor (nAChR) antagonist. Conclusion: conclusion, our demonstrated that effect HTP, increase rCBF, is mediated via activation α4β2-like neuronal nAChRs brain.

Язык: Английский

Impact of heated tobacco products on biomarkers of potential harm and adverse events: a systematic review and meta-analysis DOI
Sophie Braznell, Sarah Dance, Jamie Hartmann‐Boyce

и другие.

Tobacco Control, Год журнала: 2025, Номер unknown, С. tc - 059000

Опубликована: Апрель 29, 2025

Objective To systematically review available data on the effects of heated tobacco products (HTPs) biomarkers potential harm (BoPH) and adverse events, including comparison to cigarettes, e-cigarettes smoking abstinence. Data sources Web Science, Scopus, MedRxiv, ClinicalTrials.gov, ICTRP database HTP manufacturer libraries were searched from January 2010 December 2024. Study selection Included studies interventional clinical trials any design that measured BoPH or events in adults assigned a marketed another either extraction Two reviewers independently extracted into predesigned form assessed risk bias using Cochrane’s Risk Bias tool version 1. synthesis synthesised effect direction plots. A random-effects model was used calculate pooled ratios for event data. 40 (10 independent, 29 industry-affiliated 1 unclear affiliation) included. Only nine lasted longer than 5 days. 19 involved intervention just once. high 32 8. 143 indicated short-term use had mixed compared with The rate reporting not significantly different between comparator group. Conclusions Despite growing evidence base, significant limitations hinder interpretation data, which do yet provide clear indication benefit, even cigarettes. Longer, better quality independent industry funding are needed determine health impacts HTPs.

Язык: Английский

Процитировано

1
Confirmation of absence of combustion in an electronically heated tobacco product using multiple methods DOI

Yasunori Takahashi,

Kazushi Matsumura,

Hiroshi Fukudomi

и другие.

Next research., Год журнала: 2025, Номер unknown, С. 100294 - 100294

Опубликована: Март 1, 2025

Язык: Английский

Процитировано

0
Association between use of heated tobacco products and long-term respiratory effects considering smoking history: internet-based cross-sectional study in Japan DOI Creative Commons

Yuki Kimura,

Minoru Sugita

BMC Public Health, Год журнала: 2024, Номер 24(1)

Опубликована: Окт. 11, 2024

With the use of heated tobacco products (HTPs) becoming more widespread in Japan, interest health effects HTP has grown. Since majority users are former smokers, information about user's smoking history and status before is needed when assessing use. The limited epidemiological studies available did not consistently consider this adequately, therefore we conducted a cross-sectional study investigating association between respiratory chronic diseases symptoms. questionnaires were sent to research panel members Japan via Internet, individuals who met criteria either current exclusive users, cigarette or those had never used selected. Information participants' they HTPs was obtained. participant impacts on outcomes upon switching assessed using logistic regression model. odds ratio (OR) for relative calculated. OR calculated under two scenarios, one which ignored considered. Of participants from whom responses obtained, 17,406 included analysis. Almost all participating long-term (mean: 30.8 years), occurrence both after start reported. ORs, without adjustment with were, 3.23 (95% CI: 1.37–7.61) 1.85 0.70–4.89) respectively COPD, same as other outcomes. These results suggest that affects outcomes, underscore importance considering effect duration considerably shorter than at present, further research, such follow-up surveys use, will be necessary.

Язык: Английский

Процитировано

0
Association between use of heated tobacco products and long-term health effects considering smoking history: Internet-based cross-sectional study in Japan DOI

Yuki Kimura,

Minoru Sugita

Research Square (Research Square), Год журнала: 2024, Номер unknown

Опубликована: Июнь 27, 2024

Abstract Background With the use of heated tobacco products (HTPs) becoming more widespread in Japan, interested health effects HTP have grown. Since vast majority users are former smokers, information about user's smoking history and status before is needed when assessing use. The limited epidemiological studies available did not consistently considered this information. Methods We conducted a cross-sectional study investigating relationship between respiratory chronic diseases symptoms. A large-scale research panel Japan managed by Cross Marketing Inc. was randomly sent questionnaires via Internet, individuals who met criteria were either current exclusive users, cigarette or those had never used selected. And obtained participants' they HTPs. participant prior to impacts on outcomes upon switching assessed using logistic regression model. odds ratio (OR) for relative calculated. OR calculated under two scenarios, ignoring taking into account history. Results Of participants from whom responses obtained, 17,406 included analysis. Almost all participating long-term (mean: 28.6 years), occurrence both after start reported. ORs, without adjustment with were, case COPD, 3.23 (95% CI: 1.37–7.61) 1.85 0.70–4.89) respectively. These results suggest that affects outcomes. Conclusions underscore importance considering effect duration considerably shorter than at present, further research, such as follow-up surveys use, will be necessary.

Язык: Английский

Процитировано

0
Cerebral Cortical Vasodilation via Nicotinic Receptors by Heated Tobacco Product Aerosol Extract in Rats DOI Creative Commons
Sae Uchida,

Jura Moriya,

Daichi Morihara

и другие.

Journal of Vascular Research, Год журнала: 2024, Номер unknown, С. 1 - 9

Опубликована: Ноя. 5, 2024

Introduction: Smoking increases the risk of lung cancer due to a number components smoke. The use novel heated tobacco products (HTPs), alternative conventional combustion cigarettes, has increased in recent years. However, vivo biological effects HTPs are poorly understood. This study aimed clarify acute injecting aerosol extract prepared from an HTP on regional cerebral blood flow (rCBF) rat cortex by comparing them smoke combustible cigarettes. Methods: In urethane anesthetized rats, rCBF was measured using laser speckle contrast imaging simultaneously with arterial pressure. Results: Both cigarette and extract, at dose equivalent 30 μg nicotine/kg, injected intravenously, cortical without changing magnitude time course response both extracts were similar throughout area, all abolished dihydro-β-erythroidine, α4β2-preferring nicotinic acetylcholine receptor (nAChR) antagonist. Conclusion: conclusion, our demonstrated that effect HTP, increase rCBF, is mediated via activation α4β2-like neuronal nAChRs brain.

Язык: Английский

Процитировано

0