AJP Cell Physiology,
Год журнала:
2023,
Номер
326(1), С. C74 - C88
Опубликована: Ноя. 20, 2023
We
demonstrate
the
expression
and
function
of
voltage-gated
delayed
rectifier
potassium
channel
Kv2
in
vagal
nodose
neurons.
Within
sensory
neurons,
channels
limit
width
broader
C-type
but
not
narrow
A-type
action
potential.
nucleus
solitary
tract
(nTS),
location
terminal
field,
does
influence
glutamate
release.
However,
limits
potential
discharge
nTS
relay
These
data
suggest
a
critical
role
for
vagal-nTS
reflex
arc.
Bioelectronic Medicine,
Год журнала:
2024,
Номер
10(1)
Опубликована: Сен. 13, 2024
Abstract
The
identification
of
acute
cardioprotective
strategies
against
myocardial
ischemia/reperfusion
(I/R)
injury
that
can
be
applied
in
the
catheterization
room
is
currently
an
unmet
clinical
need
and
several
interventions
evaluated
past
at
pre-clinical
level
have
failed
translation.
Autonomic
imbalance,
sustained
by
abnormal
afferent
signalling,
a
key
component
I/R
injury.
Accordingly,
there
strong
rationale
for
neuromodulation
strategies,
aimed
reducing
sympathetic
activity
and/or
increasing
vagal
tone,
this
setting.
In
review
we
focus
on
cervical
nerve
stimulation
(cVNS)
transcutaneous
auricular
vagus
(taVNS);
latest
has
potential
to
overcome
issues
invasive
cVNS,
including
possibility
being
used
setting,
while
retaining
its
beneficial
effects.
First,
discuss
pathophysiology
injury,
mostly
consequence
overproduction
reactive
oxygen
species.
Second,
describe
functional
anatomy
parasympathetic
branch
autonomic
nervous
system
most
relevant
principles
bioelectronic
medicine
electrical
modulation,
with
particular
taVNS.
Then,
provide
detailed
comprehensive
summary
studies
non-invasive
VNS
support
effect
whenever
or
chronic
cardiac
specifically
setting
benefit
emerging
field
post
arrest
syndrome
(PCAS)
also
mentioned.
Indeed,
cVNS
anti-adrenergic,
anti-inflammatory,
antioxidants,
anti-apoptotic
pro-angiogenic
effect;
involved
molecular
pathways
were
already
directly
confirmed
take
place
Pre-clinical
data
clearly
show
sooner
applied,
better
outcome,
marked
infarct
size
reduction
almost
complete
left
ventricular
reverse
remodelling
when
immediately
before
during
reperfusion.
Finally,
detail
limited
but
very
promising
experience
taVNS
available
so
far.
Cancer Medicine,
Год журнала:
2023,
Номер
12(18), С. 19081 - 19090
Опубликована: Авг. 17, 2023
Cancer
is
globally
a
disease
of
significant
public
health
concern
owing
to
its
prevalence,
and
association
with
morbidity
mortality.
Thus,
cost-effective
treatments
for
cancer
are
important
help
reduce
However,
the
current
therapeutic
options
such
as
chemotherapy,
radiotherapy,
surgery
may
produce
serious
adverse
events
nausea,
vomiting,
fatigue,
peripheral
neuropathy,
especially
in
long
term.
In
addition,
these
not
be
well
tolerated
by
elderly
those
who
frail.
The
article
aimed
at
discussing
an
alternative
option,
non-invasive
vagus
nerve
stimulation
(VNS),
roles
it
plays
pathology
immunotherapy.
VNS
does
this
reducing
oxidative
stress
via
silent
information
regulator
1
(SIRT1);
inhibiting
inflammation
both
hypothalamic-pituitary-axis
(HPA)
release
corticosteroid
from
adrenal
gland,
cholinergic
anti-inflammatory
pathway
(CAP),
increasing
vagal
activity
which
helps
regulation
cell
proliferation,
differentiation,
apoptosis,
metabolism,
increase
chance
survival.
Furthermore,
complications
due
or
postoperative
ileus
severity
neuropathy
induced
improves
cancer-related
lymphopenia,
quality
life.
These
suggest
that
importance
immunotherapy
cannot
overemphasized.
Therefore,
considering
safety
cost-effectiveness,
option
worth
trying
patients,
combination
other
therapies.
Diabetes Obesity and Metabolism,
Год журнала:
2023,
Номер
25(5), С. 1162 - 1173
Опубликована: Фев. 7, 2023
Abstract
The
manifestations
of
diabetic
autonomic
neuropathy
(DAN)
are
protean
and
clinically
involve
multiple
systems,
including
the
cardiovascular
system,
gastrointestinal
genitourinary
system
as
well
sweat
glands
(sudomotor
dysfunction)
gallbladder.
In
addition,
cardiac
(CAN)
is
associated
with
a
correctible
inability
to
appreciate
correct
hypoglycaemia.
While
not
clinical
problem,
pupillary
involvement
should
be
clue
catalyst
investigate
for
other
DAN.
This
review
outlines
practical
approach
detecting
investigating
Of
particular
importance
early
detection
where
prompt
therapy
through
glycaemic
control
can
decrease
severity
CAN
decelerate
frequency
retinopathy
nephropathy
in
addition
decreasing
events
mortality.
also
plays
role
accelerating
complications
such
acute
ischaemic
stroke,
heart
failure,
medial
artery
calcinosis,
foot
ulcers,
peripheral
disease
Charcot
joints.
Many
therapies
DAN
available,
which
only
morbidity
mortality
from
DAN,
but
improve
patient's
quality
life.
However,
available
largely
symptomatic.
Biomedical Physics & Engineering Express,
Год журнала:
2024,
Номер
10(3), С. 035028 - 035028
Опубликована: Апрель 2, 2024
To
treat
diseases
associated
with
vagal
nerve
control
of
peripheral
organs,
it
is
necessary
to
selectively
activate
efferent
and
afferent
fibers
in
the
vagus.
As
a
result
nerve's
complex
anatomy,
fiber-specific
activation
proves
challenging.
Spatially
selective
neuromodulation
using
micromagnetic
stimulation(μMS)
showing
incredible
promise.
This
technique
uses
microcoils(μcoils)
generate
magnetic
fields
by
powering
them
time-varying
current.
Following
principles
Faraday's
law
induction,
highly
directional
electric
field
induced
from
field.
In
this
study
on
rodent
cervical
vagus,
solenoidalμcoil
was
oriented
at
an
angle
left
right
branches
nerve.
The
aim
measure
changes
mean
arterial
pressure
(MAP)
heart
rate
(HR)
followingμMS
Theμcoils
were
powered
single-cycle
sinusoidal
current
varying
pulse
widths(PW
=
100,
500,
1000μsec)
frequency
20
Hz.
Under
influence
isoflurane,μMS
vagus
1000μsec
PW
led
average
drop
MAP
16.75
mmHg(n
7).
contrast,μMS
under
isoflurane
resulted
11.93
mmHg
MAP(n
Surprisingly,
there
no
HR
either
or
vagalμMS
suggesting
vagusμMS
stimulation
afferent,
but
not
fibers.
urethane
anesthetized
rats,
observed
uponμMS
vagus(n
3).
These
findings
suggest
choice
anesthesia
plays
key
role
determining
efficacy
ofμMS
Absence
modulation
could
offer
alternative
treatment
options
VNS
fewer
heart-related
side-effects.
Annals of Translational Medicine,
Год журнала:
2022,
Номер
10(24), С. 1314 - 1314
Опубликована: Дек. 1, 2022
Background:
Parkinson's
disease
(PD)
is
a
common
movement
disorder
disease.
Left
vagus
nerve
stimulation
(LVNS)
potential
treatment
option
for
PD.
Compared
with
the
left
nerve,
right
more
closely
connected
midbrain
dopaminergic
neurons,
which
are
lesion
locations
of
However,
whether
(RVNS)
has
therapeutic
effect
on
PD
not
yet
been
studied.
Therefore,
in
this
study,
we
studied
and
underlying
mechanism
RVNS
using
rat
model.
Brain Sciences,
Год журнала:
2023,
Номер
13(7), С. 1032 - 1032
Опубликована: Июль 6, 2023
Communication
between
the
ovaries
and
central
nervous
system
occurs
by
peripheral
innervation
through
celiac
plexus,
superior
ovarian
nerve,
plexus
nerve.
The
vagus
nerve
is
involved
in
regulating
ovaries,
but
neuroanatomical
pathway
that
links
them
not
clear.
Adult
female
rats
were
used
for
gross
anatomy,
acetylcholinesterase
histochemistry,
immunofluorescence
analysis
of
tyrosine
hydroxylase
(TH),
choline
acetyltransferase
(ChAT),
tryptophan
2
(TPH).
results
obtained
indicate
right
(RVN)
travels
parallel
caudal
to
esophagus,
where
three
branches
identified.
Also,
a
vagal
(RVP)
formed
microganglia
was
described,
establishing
communication
with
mainly
reactive
(TH);
some
serotoninergic
cholinergic
neurons
also
found.
left
(LVN)
over
bifurcates
before
its
insertion
into
stomach
enters
RCG.
This
biochemical
description
RVN
LVN
rat
suggests
RVP
presynaptic
catecholaminergic
terminals
neurons.
information
could
support
detailed
studies
identify
type
neural
signaling
abdominal
control
AJP Heart and Circulatory Physiology,
Год журнала:
2024,
Номер
327(1), С. H70 - H79
Опубликована: Май 3, 2024
Activation
of
the
vagus
nerve
mediates
cardioprotection
and
attenuates
myocardial
ischemia/reperfusion
(I/R)
injury.
In
response
to
vagal
activation,
acetylcholine
(ACh)
is
released
from
intracardiac
nervous
system
(ICNS)
activates
intracellular
cardioprotective
signaling
cascades.
Recently,
however,
a
nonneuronal
cholinergic
cardiac
(NNCCS)
in
cardiomyocytes
has
been
described
as
an
additional
source
ACh.
To
investigate
whether
NNCCS
absence
ICNS
we
used
reductionist
approach
isolated
adult
rat
ventricular
without
neuronal
cells,
using
hypoxic
preconditioning
(HPC)
protective
stimulus.
Adult
were
isolated,
cells
was
confirmed,
HPC
induced
by
10/20
min
hypoxia/reoxygenation
(H/R)
before
subjection
30/5
H/R
simulate
I/R
Cardiomyocyte
viability
assessed
trypan
blue
staining
at
baseline
after
HPC+H/R
or
H/R.
Intra-
extracellular
ACh
quantified
liquid
chromatography-coupled
mass
spectrometry
baseline,
HPC,
hypoxia,
reoxygenation,
respectively.
subset
experiments,
muscarinic
nicotinic
receptor
(m-
nAChR)
antagonists
added
during
(69
±
4%)
reduced
(10
3%).
With
cardiomyocyte
preserved
(25
6%).
increased
hypoxia;
further
both
intra-
(from
0.9
0.7
1.5
1.0
nmol/mg;
0.6
1.1
nmol/mg,
respectively).
The
addition
mAChR
nAChR
had
no
impact
on
HPC's
protection;
protection
abrogated
when
(cardiomyocyte
H/R:
23
5%;
13
4%).
conclusion,
activation
involved
increases
H/R,
m-
nAChRs
are
causally
interplay
between
upstream
metabolism
needs
be
investigated
future
studies.
