Molecules,
Год журнала:
2021,
Номер
26(18), С. 5705 - 5705
Опубликована: Сен. 21, 2021
Nitric
oxide
(NO)
is
a
key
signaling
molecule
that
acts
in
various
physiological
processes
such
as
cellular
metabolism,
vasodilation
and
transmission
of
nerve
impulses.
A
wide
number
vascular
diseases
well
immune
neurodegenerative
disorders
were
found
to
be
directly
associated
with
disruption
NO
production
living
organisms.
These
issues
justify
constant
search
novel
NO-donors
improved
pharmacokinetic
profiles
prolonged
action.
In
series
known
structural
classes
capable
release,
heterocyclic
are
special
importance
due
their
increased
hydrolytic
stability
low
toxicity.
It
no
wonder
synthetic
biochemical
investigations
have
emerged
significantly
recent
years.
this
review,
we
summarized
advances
the
synthesis,
reactivity
biomedical
applications
promising
(furoxans,
sydnone
imines,
pyridazine
dioxides,
azasydnones).
The
potential
each
system
along
mechanisms
action
emphasized.
Green Chemistry,
Год журнала:
2023,
Номер
25(17), С. 6686 - 6693
Опубликована: Янв. 1, 2023
A
green
electrochemical
approach
for
the
intramolecular
formation
of
N–N
bonds
was
realized
to
prepare
a
diverse
range
valuable
1,2,3-triazole
1-oxides,
making
this
nitrogen
heterocycle
subclass
full
member
classes
organic
compounds.
Organic Process Research & Development,
Год журнала:
2024,
Номер
28(7), С. 2794 - 2805
Опубликована: Июль 5, 2024
The
synthesis
of
the
highly
energetic
pharmaceutical
intermediate
4-methyl-1,2,5-oxadiazole-3-carboxylic
acid
via
cyclization
(2E,3E)-butane-2,3-dione
dioxime
followed
by
selective
oxidation
resulting
3,4-dimethyl-1,2,5-oxadiazole
was
developed
to
support
sample
production
for
clinical
trials.
Rigorous
process
safety
evaluations
revealed
many
potential
risks
associated
with
involved
compounds
and
high
exothermicity
reaction.
A
continuous
flow
mitigate
thermal
instability
starting
material
product
3,4-dimethyl-1,2,5-oxadiazole.
much
safer
exothermic
involving
portion-wise
addition
potassium
permanganate
avoid
accumulation
reactive
chemicals.
desired
isolated
as
N-methyl
morpholine
4-methyl-1,2,5-oxadiazole-3-carboxylate
handling
potentially
explosive
in
its
solid
form.
successfully
scaled
up
afford
a
total
93.52
kg
drug
substance.
ChemPlusChem,
Год журнала:
2020,
Номер
85(1), С. 237 - 239
Опубликована: Янв. 1, 2020
Abstract
The
synthesis
and
crystal
structure
of
the
heterocyclic
explosive
bis(nitroxymethylisoxazolyl)
furoxan,
C
10
H
6
N
O
,
are
described.
In
addition,
we
report
its
physical
properties
theoretical
performance.
This
material
was
found
to
exhibit
standalone
melt‐castable
properties,
with
a
melting
point
89.8
°C
an
onset
decomposition
temperature
193.8
°C.
Bis(nitroxymethylisoxazolyl)
furoxan
features
insensitive
behavior
impact,
friction,
electrostatic
discharge,
calculated
detonation
pressure
about
25
%
higher
than
state‐of‐the‐art
TNT.
Molecules,
Год журнала:
2021,
Номер
26(18), С. 5705 - 5705
Опубликована: Сен. 21, 2021
Nitric
oxide
(NO)
is
a
key
signaling
molecule
that
acts
in
various
physiological
processes
such
as
cellular
metabolism,
vasodilation
and
transmission
of
nerve
impulses.
A
wide
number
vascular
diseases
well
immune
neurodegenerative
disorders
were
found
to
be
directly
associated
with
disruption
NO
production
living
organisms.
These
issues
justify
constant
search
novel
NO-donors
improved
pharmacokinetic
profiles
prolonged
action.
In
series
known
structural
classes
capable
release,
heterocyclic
are
special
importance
due
their
increased
hydrolytic
stability
low
toxicity.
It
no
wonder
synthetic
biochemical
investigations
have
emerged
significantly
recent
years.
this
review,
we
summarized
advances
the
synthesis,
reactivity
biomedical
applications
promising
(furoxans,
sydnone
imines,
pyridazine
dioxides,
azasydnones).
The
potential
each
system
along
mechanisms
action
emphasized.
