Recent advances in post-chiroptical manipulation of supramolecular aggregates assembled with molecular modules
Science China Chemistry,
Год журнала:
2024,
Номер
67(9), С. 2842 - 2863
Опубликована: Июль 23, 2024
Язык: Английский
Non‐Equilibrium Dissipative Assembly with Switchable Biological Functions
Angewandte Chemie International Edition,
Год журнала:
2024,
Номер
63(48)
Опубликована: Авг. 22, 2024
Abstract
Natural
dissipative
assembly
(DSA)
often
exhibit
energy‐driven
shifts
in
natural
functions.
However,
creating
man‐made
DSA
that
can
mimic
such
biological
activities
transformation
remains
relatively
rare.
Herein,
we
introduce
a
cytomembrane‐like
system
based
on
chiral
supramolecules.
This
employs
benzoyl
cysteine
an
out
of
equilibrium
manner,
enabling
the
biofunctions
while
minimizing
material
use.
Specifically,
aroyl‐cystine
derivatives
primarily
assemble
into
stable
M‐helix
nanofibers
under
conditions.
These
enhance
fibroblast
adhesion
and
proliferation
through
stereospecific
interactions
with
cellular
membranes.
Upon
addition
chemical
fuels,
these
functional
temporarily
transform
non‐equilibrium
nanospheres,
facilitating
efficient
drug
delivery.
Subsequently,
nanospheres
revert
to
their
original
nanofiber
state,
effectively
recycling
drug.
The
programmable
function‐shifting
ability
this
establishes
it
as
novel,
fuel‐driven
delivery
vehicle.
And
bioactive
not
only
addresses
gap
synthetic
DSAs
within
applications
but
also
sets
stage
for
innovative
designs
′living′
materials.
Язык: Английский
Chemical reaction steers spatiotemporal self‐assembly of supramolecular hydrogels
ChemPlusChem,
Год журнала:
2024,
Номер
unknown
Опубликована: Июнь 26, 2024
Supramolecular
structures
are
widespread
in
living
system,
which
usually
spatiotemporally
regulated
by
sophisticated
metabolic
processes
to
enable
vital
biological
functions.
Inspired
tremendous
efforts
have
been
made
realize
spatiotemporal
control
over
the
self-assembly
of
supramolecular
materials
synthetic
scenario
coupling
chemical
reaction
with
molecular
process.
In
this
review,
we
focused
on
works
related
hydrogels
that
space
and
time
using
reaction.
Firstly,
summarized
how
spatially
controlled
can
be
achieved
via
reaction-instructed
self-assembly,
application
such
a
methodology
biotherapy
was
discussed
as
well.
Second,
reviewed
dynamic
dictated
networks
evolve
their
properties
against
time.
Third,
recent
progresses
both
though
reaction-diffusion-coupled
approach.
Finally,
provided
perspective
further
development
future.
Язык: Английский
Non‐Equilibrium Dissipative Assembly with Switchable Biological Functions
Angewandte Chemie,
Год журнала:
2024,
Номер
136(48)
Опубликована: Авг. 22, 2024
Abstract
Natural
dissipative
assembly
(DSA)
often
exhibit
energy‐driven
shifts
in
natural
functions.
However,
creating
man‐made
DSA
that
can
mimic
such
biological
activities
transformation
remains
relatively
rare.
Herein,
we
introduce
a
cytomembrane‐like
system
based
on
chiral
supramolecules.
This
employs
benzoyl
cysteine
an
out
of
equilibrium
manner,
enabling
the
biofunctions
while
minimizing
material
use.
Specifically,
aroyl‐cystine
derivatives
primarily
assemble
into
stable
M‐helix
nanofibers
under
conditions.
These
enhance
fibroblast
adhesion
and
proliferation
through
stereospecific
interactions
with
cellular
membranes.
Upon
addition
chemical
fuels,
these
functional
temporarily
transform
non‐equilibrium
nanospheres,
facilitating
efficient
drug
delivery.
Subsequently,
nanospheres
revert
to
their
original
nanofiber
state,
effectively
recycling
drug.
The
programmable
function‐shifting
ability
this
establishes
it
as
novel,
fuel‐driven
delivery
vehicle.
And
bioactive
not
only
addresses
gap
synthetic
DSAs
within
applications
but
also
sets
stage
for
innovative
designs
′living′
materials.
Язык: Английский