Non‐Equilibrium Dissipative Assembly with Switchable Biological Functions DOI
Peng Zhao, Yuanfeng Zhao, Yan Lü

и другие.

Angewandte Chemie, Год журнала: 2024, Номер 136(48)

Опубликована: Авг. 22, 2024

Abstract Natural dissipative assembly (DSA) often exhibit energy‐driven shifts in natural functions. However, creating man‐made DSA that can mimic such biological activities transformation remains relatively rare. Herein, we introduce a cytomembrane‐like system based on chiral supramolecules. This employs benzoyl cysteine an out of equilibrium manner, enabling the biofunctions while minimizing material use. Specifically, aroyl‐cystine derivatives primarily assemble into stable M‐helix nanofibers under conditions. These enhance fibroblast adhesion and proliferation through stereospecific interactions with cellular membranes. Upon addition chemical fuels, these functional temporarily transform non‐equilibrium nanospheres, facilitating efficient drug delivery. Subsequently, nanospheres revert to their original nanofiber state, effectively recycling drug. The programmable function‐shifting ability this establishes it as novel, fuel‐driven delivery vehicle. And bioactive not only addresses gap synthetic DSAs within applications but also sets stage for innovative designs ′living′ materials.

Язык: Английский

Recent advances in post-chiroptical manipulation of supramolecular aggregates assembled with molecular modules DOI

Yanling Shen,

Wanhua Wu, Zhipeng Yu

и другие.

Science China Chemistry, Год журнала: 2024, Номер 67(9), С. 2842 - 2863

Опубликована: Июль 23, 2024

Язык: Английский

Процитировано

1

Non‐Equilibrium Dissipative Assembly with Switchable Biological Functions DOI
Peng Zhao, Yuanfeng Zhao, Yan Lü

и другие.

Angewandte Chemie International Edition, Год журнала: 2024, Номер 63(48)

Опубликована: Авг. 22, 2024

Abstract Natural dissipative assembly (DSA) often exhibit energy‐driven shifts in natural functions. However, creating man‐made DSA that can mimic such biological activities transformation remains relatively rare. Herein, we introduce a cytomembrane‐like system based on chiral supramolecules. This employs benzoyl cysteine an out of equilibrium manner, enabling the biofunctions while minimizing material use. Specifically, aroyl‐cystine derivatives primarily assemble into stable M‐helix nanofibers under conditions. These enhance fibroblast adhesion and proliferation through stereospecific interactions with cellular membranes. Upon addition chemical fuels, these functional temporarily transform non‐equilibrium nanospheres, facilitating efficient drug delivery. Subsequently, nanospheres revert to their original nanofiber state, effectively recycling drug. The programmable function‐shifting ability this establishes it as novel, fuel‐driven delivery vehicle. And bioactive not only addresses gap synthetic DSAs within applications but also sets stage for innovative designs ′living′ materials.

Язык: Английский

Процитировано

1

Chemical reaction steers spatiotemporal self‐assembly of supramolecular hydrogels DOI
Hucheng Wang,

Shengyu Bai,

Guanyao Gu

и другие.

ChemPlusChem, Год журнала: 2024, Номер unknown

Опубликована: Июнь 26, 2024

Supramolecular structures are widespread in living system, which usually spatiotemporally regulated by sophisticated metabolic processes to enable vital biological functions. Inspired tremendous efforts have been made realize spatiotemporal control over the self-assembly of supramolecular materials synthetic scenario coupling chemical reaction with molecular process. In this review, we focused on works related hydrogels that space and time using reaction. Firstly, summarized how spatially controlled can be achieved via reaction-instructed self-assembly, application such a methodology biotherapy was discussed as well. Second, reviewed dynamic dictated networks evolve their properties against time. Third, recent progresses both though reaction-diffusion-coupled approach. Finally, provided perspective further development future.

Язык: Английский

Процитировано

0

Non‐Equilibrium Dissipative Assembly with Switchable Biological Functions DOI
Peng Zhao, Yuanfeng Zhao, Yan Lü

и другие.

Angewandte Chemie, Год журнала: 2024, Номер 136(48)

Опубликована: Авг. 22, 2024

Abstract Natural dissipative assembly (DSA) often exhibit energy‐driven shifts in natural functions. However, creating man‐made DSA that can mimic such biological activities transformation remains relatively rare. Herein, we introduce a cytomembrane‐like system based on chiral supramolecules. This employs benzoyl cysteine an out of equilibrium manner, enabling the biofunctions while minimizing material use. Specifically, aroyl‐cystine derivatives primarily assemble into stable M‐helix nanofibers under conditions. These enhance fibroblast adhesion and proliferation through stereospecific interactions with cellular membranes. Upon addition chemical fuels, these functional temporarily transform non‐equilibrium nanospheres, facilitating efficient drug delivery. Subsequently, nanospheres revert to their original nanofiber state, effectively recycling drug. The programmable function‐shifting ability this establishes it as novel, fuel‐driven delivery vehicle. And bioactive not only addresses gap synthetic DSAs within applications but also sets stage for innovative designs ′living′ materials.

Язык: Английский

Процитировано

0