Cancers,
Год журнала:
2024,
Номер
16(18), С. 3156 - 3156
Опубликована: Сен. 14, 2024
Oral
cavity
and
lip
cancers
are
the
16th
most
common
cancer
in
world.
It
is
widely
known
that
a
lack
of
public
knowledge
about
precancerous
lesions,
oral
symptoms,
risk
factors
leads
to
diagnostic
delay
therefore
lower
survival
rate.
Risk
factors,
which
include
drinking
alcohol,
smoking,
HPV
infection,
pro-inflammatory
factor-rich
diet,
poor
hygiene,
must
be
avoided
by
general
population.
Regular
clinical
examinations
should
enriched
an
search
protocol
for
summarized
this
review.
Moreover,
new
methods,
some
already
available
(vital
tissue
staining,
optical
imaging,
cytology,
salivary
biomarkers,
artificial
intelligence,
colposcopy,
spectroscopy),
newly
researched
techniques
increase
likelihood
stopping
pathological
process
at
stage.
Well-established
treatments
(surgery,
radiotherapy,
chemotherapy,
immunotherapy)
continuously
being
developed
using
novel
technologies,
increasing
their
success
Additionally,
researched.
This
review
presents
glance
cancer—its
current
classification
epidemiology—and
will
provide
insights
into
development
methods
therapies.
Natural
small
molecular
drugs
with
excellent
biocompatibility,
diverse
pharmacological
activities,
and
wide
sources
play
an
increasingly
important
role
in
the
development
of
new
drug
disease
treatment.
In
recent
years,
utilization
paclitaxel,
camptothecin,
rhein,
curcumin,
other
natural
unique
rigid
backbone
structures
modifiable
multiple
sites
as
building
blocks
to
form
gels
by
self-assembly
has
attracted
widespread
attention.
The
obtained
low-molecular-weight
supramolecular
gel
not
only
retains
general
characteristics
but
also
overcomes
shortcomings
drugs,
such
poor
water
solubility
low
bioavailability.
It
advantages
high
loading,
toxicity,
outstanding
stimulus
responsiveness,
which
is
widely
used
biomedical
fields.
Here,
we
provided
a
comprehensive
review
natural-drugs-based
reported
years
summarized
their
assembly
mechanism,
structure,
properties,
potential
applications.
expected
provide
reference
for
further
research
gels.
Expert Opinion on Drug Discovery,
Год журнала:
2023,
Номер
18(11), С. 1259 - 1272
Опубликована: Авг. 31, 2023
ABSTRACTIntroduction
Natural
products
(NPs)
are
a
desirable
source
of
new
therapeutics
due
to
their
structural
diversity
and
evolutionarily
optimized
bioactivities.
NPs
derivatives
account
for
roughly
70%
approved
pharmaceuticals.
However,
the
rate
at
which
novel
discovered
has
decreased.
To
accelerate
microbial
NP
discovery
process,
machine
learning
(ML)
is
being
applied
numerous
areas
development.Areas
covered
This
review
explores
utility
ML
various
phases
drug
pipeline,
discussing
concrete
examples
throughout
each
major
phase:
genome
mining,
dereplication,
biological
target
prediction.
Moreover,
authors
discuss
how
approaches
can
be
semi-synthetic
discovery.Expert
opinion
Despite
important
role
that
play
in
development
drugs,
declined
challenges
associated
with
conventional
process.
positioned
overcome
these
limitations
given
its
ability
model
complex
datasets
generalize
chemical
sequence
space.
Unsurprisingly,
comes
own
must
considered
successful
implementation.
The
stress
importance
continuing
build
high
quality
open
access
further
increase
discovery.KEYWORDS:
Artificial
IntelligenceMachine
LearningNatural
ProductsDrug
DiscoveryGenome
MiningDereplicationTarget
Prediction
Article
highlights
Microbial
natural
promising
therapeutics.Machine
increasingly
relieve
bottlenecks
product
process.Machine
allowed
exploration
biosynthetic
gene
clusters
spaces.Machine
been
interpretation
metabolomic
data,
leveraged
efficient
dereplication
secondary
metabolites.Machine
facilitated
prediction,
providing
insight
into
mechanisms
action
products.Generative
models
have
improved
design
product-inspired
libraries
by
preserving
features
bioactivity
products.Declaration
interestJM
Stokes
co-founder
scientific
director
Phare
Bio.
no
other
relevant
affiliations
or
financial
involvement
any
organization
entity
interest
conflict
subject
matter
materials
discussed
manuscript
apart
from
those
disclosed.Reviewer
disclosuresPeer
reviewers
on
this
relationships
disclose.Additional
informationFundingThe
funded
David
Braley
Centre
Antibiotic
Discovery,
Sciences
Engineering
Research
Council
Canada
Weston
Family
Foundation.
Cancers,
Год журнала:
2024,
Номер
16(18), С. 3156 - 3156
Опубликована: Сен. 14, 2024
Oral
cavity
and
lip
cancers
are
the
16th
most
common
cancer
in
world.
It
is
widely
known
that
a
lack
of
public
knowledge
about
precancerous
lesions,
oral
symptoms,
risk
factors
leads
to
diagnostic
delay
therefore
lower
survival
rate.
Risk
factors,
which
include
drinking
alcohol,
smoking,
HPV
infection,
pro-inflammatory
factor-rich
diet,
poor
hygiene,
must
be
avoided
by
general
population.
Regular
clinical
examinations
should
enriched
an
search
protocol
for
summarized
this
review.
Moreover,
new
methods,
some
already
available
(vital
tissue
staining,
optical
imaging,
cytology,
salivary
biomarkers,
artificial
intelligence,
colposcopy,
spectroscopy),
newly
researched
techniques
increase
likelihood
stopping
pathological
process
at
stage.
Well-established
treatments
(surgery,
radiotherapy,
chemotherapy,
immunotherapy)
continuously
being
developed
using
novel
technologies,
increasing
their
success
Additionally,
researched.
This
review
presents
glance
cancer—its
current
classification
epidemiology—and
will
provide
insights
into
development
methods
therapies.
