Abstract
Introduction
Longitudinal
biomarkers
in
patients
with
community-acquired
pneumonia
(CAP)
may
help
monitoring
of
disease
progression
and
treatment
response.
The
metabolic
host
response
could
be
a
potential
source
such
since
it
closely
associates
the
current
health
status
patient.
Objectives
In
this
study
we
performed
longitudinal
metabolite
profiling
CAP
for
comprehensive
range
metabolites
to
identify
biomarkers.
Methods
Previously
collected
serum
samples
from
confirmed
Streptococcus
pneumoniae
infection
(n
=
25)
were
used.
Samples
at
multiple
time
points,
up
30
days
after
admission.
A
wide
was
measured,
including
amines,
acylcarnitines,
organic
acids,
lipids.
associations
between
C-reactive
protein
(CRP),
procalcitonin,
CURB
severity
score
admission,
total
length
stay
evaluated.
Results
Distinct
profiles
identified,
cholesteryl
esters,
diacyl-phosphatidylethanolamine,
diacylglycerols,
lysophosphatidylcholines,
sphingomyelin,
triglycerides.
Positive
correlations
found
CRP
phosphatidylcholine
(34:1)
(cor
0.63)
negative
nine
lysophosphocholines
−
0.57
0.74).
negatively
associated
six
metabolites,
acylcarnitines
(tau
0.64
0.58).
Negative
triglycerides
(TGs),
especially
TGs
(60:3)
(58:2)
0.63
0.61).
Conclusion
identified
provide
insight
into
biological
mechanisms
underlying
interest
exploration
as
biomarker.
Nucleic Acids Research,
Год журнала:
2023,
Номер
52(D1), С. D1450 - D1464
Опубликована: Окт. 18, 2023
Abstract
Distinct
from
the
traditional
diagnostic/prognostic
biomarker
(adopted
as
indicator
of
disease
state/process),
therapeutic
(ThMAR)
has
emerged
to
be
very
crucial
in
clinical
development
and
practice
all
therapies.
There
are
five
types
ThMAR
that
have
been
found
play
indispensable
roles
various
stages
drug
discovery,
such
as:
Pharmacodynamic
Biomarker
essential
for
guaranteeing
pharmacological
effects
a
therapy,
Safety
critical
assessing
extent
or
likelihood
therapy-induced
toxicity,
Monitoring
guiding
management
by
serially
measuring
patients’
status,
Predictive
maximizing
outcome
therapy
specific
individuals,
Surrogate
Endpoint
fundamental
accelerating
approval
therapy.
However,
these
data
ThMARs
not
comprehensively
described
any
existing
databases.
Herein,
database,
named
‘TheMarker’,
was
therefore
constructed
(a)
systematically
offer
used
at
different
development,
(b)
describe
information
largest
number
drugs
among
available
databases,
(c)
extensively
cover
widest
classes
just
focusing
on
anticancer
These
TheMarker
expected
great
implication
significant
impact
discovery
practice,
it
is
freely
accessible
without
login
requirement
at:
https://idrblab.org/themarker.
Advanced Drug Delivery Reviews,
Год журнала:
2024,
Номер
215, С. 115421 - 115421
Опубликована: Авг. 17, 2024
Model-informed
precision
dosing
(MIPD)
stands
as
a
significant
development
in
personalized
medicine
to
tailor
drug
individual
patient
characteristics.
MIPD
moves
beyond
traditional
therapeutic
monitoring
(TDM)
by
integrating
mathematical
predictions
of
dosing,
and
considering
patient-specific
factors
(patient
characteristics,
measurements)
well
different
sources
variability.
For
this
purpose,
rigorous
model
qualification
is
required
for
the
application
patients.
This
review
delves
into
new
methods
selection
validation,
also
highlighting
role
machine
learning
improving
MIPD,
utilization
biosensors
real-time
monitoring,
potential
models
biomarkers
efficacy
or
toxicity
dosing.
The
clinical
evidence
TDM
discussed
various
medical
fields
including
infection
medicine,
oncology,
transplant
inflammatory
bowel
diseases,
thereby
underscoring
pharmacokinetics/pharmacodynamics
specific
biomarkers.
Further
research,
particularly
randomized
trials,
warranted
corroborate
value
enhancing
outcomes
advancing
medicine.
Nature Communications,
Год журнала:
2021,
Номер
12(1)
Опубликована: Сен. 28, 2021
Collateral
sensitivity
(CS)-based
antibiotic
treatments,
where
increased
resistance
to
one
leads
a
second
antibiotic,
may
have
the
potential
limit
emergence
of
antimicrobial
resistance.
However,
it
remains
unclear
how
best
design
CS-based
treatment
schedules.
To
address
this
problem,
we
use
mathematical
modelling
study
effects
pathogen-
and
drug-specific
characteristics
for
different
designs
on
bacterial
population
dynamics
evolution.
We
confirm
that
simultaneous
one-day
cycling
treatments
could
supress
in
presence
CS.
show
efficacy
therapies
depends
critically
order
drug
administration.
Finally,
find
reciprocal
CS
is
not
essential
suppress
resistance,
result
significantly
broadens
options
given
ubiquity
one-way
pathogens.
Overall,
our
analyses
identify
key
principles
strategies
provide
guidance
develop
schedules
Inflammation
is
often
associated
with
the
impairment
of
ability
to
sustain
consequences
physical,
chemical,
nutritional,
and
antigenic
triggers
inflammation.
The
process
immunosenescence
may
only
partially
be
explained
by
senescence
cells,
tissues,
or
organism,
and,
hence,
hallmarks
markedly
differentially
affected
history
an
individual's
pathogenic
encounter.
a
key
component
immunosenescence,
which
itself
direct
consequence
aging.
This
review
article
highlights
therapeutic
interventions
for
slowing
processes
inflamm-aging
possible
reversal
aging
includes
domains
immunomodulatory
interventions,
vaccination
strategies,
nutritional
stem
cell
therapies,
personalized
medicine,
microbiome
positive
effects
physical
activity
exercise.
Clinical Pharmacokinetics,
Год журнала:
2022,
Номер
61(5), С. 593 - 617
Опубликована: Фев. 25, 2022
The
pathophysiology
of
sepsis
alters
drug
pharmacokinetics,
resulting
in
inadequate
exposure
and
target-site
concentration.
Suboptimal
leads
to
treatment
failure
the
development
antimicrobial
resistance.
Therefore,
we
seek
optimize
therapy
by
selecting
right
correct
dosage.
A
prerequisite
for
achieving
this
goal
is
characterization
understanding
mechanisms
pharmacokinetic
alterations.
However,
most
infections
take
place
not
blood
but
different
body
compartments.
Since
tissue
assessment
feasible
daily
practice,
need
tailor
antibiotic
according
specific
patient's
pathophysiological
processes.
complex
ineffectiveness
current
targeted
therapies
suggest
that
treatments
guided
biomarkers
predicting
concentration
could
provide
a
new
therapeutic
strategy.
Inflammation,
endothelial
coagulation
activation
markers,
flow
parameters
might
be
indicators
impaired
distribution.
Moreover,
hepatic
renal
dysfunction
can
predict
only
metabolism
clearance
also
Identification
direct
dosing
timely
feedback
on
its
effectiveness.
decrease
resistance
mortality
critically
ill
patients.
This
article
fills
literature
gap
characterizing
patient
used
unbound
plasma-to-tissue
distribution
Although
all
must
clinically
evaluated
with
ultimate
combining
them
scoring
system,
support
concept
appropriate
dosing.
Journal of Infection,
Год журнала:
2024,
Номер
88(5), С. 106156 - 106156
Опубликована: Апрель 8, 2024
To
identify
patterns
in
inflammatory
marker
and
vital
sign
responses
adult
with
suspected
bloodstream
infection
(BSI)
define
expected
trends
normal
recovery.
Emerging
as
a
promising
novel
amplification
technique,
the
exponential
reaction
(EXPAR)
offers
significant
advantages
due
to
its
potent
capability,
straightforward
design,
rapid
kinetics,
and
isothermal
operation.
The
past
few
years
have
witnessed
swift
advancements
refinements
in
EXPAR-based
technologies,
with
numerous
high-performance
biosensing
systems
documented.
A
deeper
understanding
of
EXPAR
mechanism
has
facilitated
proposal
strategies
overcome
limitations
inherent
traditional
EXPAR.
Furthermore,
synergistic
integration
diverse
methodologies,
including
use
CRISPR/Cas
system,
metal
nanoparticles,
aptamers,
alternative
techniques,
enzymes,
significantly
bolstered
analytical
efficacy,
aiming
enhance
specificity,
sensitivity,
efficiency.
This
comprehensive
review
presents
detailed
exposition
analyzes
primary
challenges.
Additionally,
we
summarize
latest
research
biomedical
field
concerning
technologies
for
sensing
strategies.
Finally,
discuss
challenges
future
prospects
technology
realms
clinical
applications.
Abstract
Background
The
level
of
inflammation
alters
drug
pharmacokinetics
(PK)
in
critically
ill
patients.
This
might
compromise
treatment
efficacy.
Understanding
the
specific
effects
inflammation,
measured
by
biomarkers,
on
absorption,
distribution,
metabolism,
and
excretion
is
help
optimizing
dosing
strategies.
Objectives
review
investigates
relationship
between
inflammatory
biomarkers
PK
parameters
metabolism
(ADME)
patients,
providing
insight
complexity
drugs
Method
Following
PRISMA
guidelines,
we
conducted
a
comprehensive
search
Medline,
Embase,
Web
Science,
Cochrane
databases
(January
1946–November
2023).
Studies
examining
parameters,
or
exposure
patients
were
included.
Records
screened
title,
abstract,
full
text,
with
any
discrepancies
resolved
through
discussion
consultation
third
reviewer.
Results
Of
4479
records
screened,
31
met
our
inclusion
criteria:
2
7
17
6
excretion.
In
general,
results
are
only
available
for
limited
number
drugs,
most
studies
done
looking
at
one
components
ADME.
Higher
levels
may
increase
decrease
absorption
depending
whether
undergoes
hepatic
first-pass
elimination.
For
negatively
correlated
protein
binding
capacity,
positively
cerebrospinal
fluid
penetration,
peritoneal
penetration.
Metabolizing
capacity
was
inversely
biomarkers.
Regarding
excretion,
can
lead
to
reduced
clearance,
except
neonatal
population.
Conclusion
Inflammatory
offer
valuable
information
regarding
altered
Our
findings
emphasize
need
consider
inflammation-driven
variability
when
individualizing
therapy
this
setting,
same
time
research
certain
needs
further
research,
also
including
pharmacodynamics.
Russian Sklifosovsky Journal Emergency Medical Care,
Год журнала:
2025,
Номер
13(4), С. 684 - 690
Опубликована: Янв. 28, 2025
ABSTRACT
The
article
provides
a
historical
review
of
the
literature
describing
evolution
bladder
drainage
and
types
urinary
catheters
currently
in
use.
Complications
various
methods
are
classified
described,
measures
for
their
prevention
proposed.
AIM
OF
STUDY
To
study
draining
methods,
advantages
disadvantages,
possible
complications
each
method.
OBJECTIVES
assess
indications
use
method,
to
focus
attention
health
workers
on
possibility
choosing
optimal
method
draining,
depending
clinical
situation.
