Molecules,
Год журнала:
2024,
Номер
29(11), С. 2615 - 2615
Опубликована: Июнь 2, 2024
This
paper
explores
the
emerging
subject
of
extracting
tannins
from
various
plant
sources
using
deep
eutectic
solvents
(DESs).
Tannins
are
widely
used
in
food
and
feed
industries
as
they
have
outstanding
antioxidant
qualities
greatly
enhance
flavor
nutritional
content
a
wide
range
products.
Organic
frequently
traditional
extraction
techniques,
which
raises
questions
about
their
safety
for
human
health
environment.
DESs
present
prospective
substitute
because
low
toxicity,
adaptability,
environmental
friendliness.
The
fundamental
ideas
supporting
application
plant-based
materials
daily
life
all
well
covered
this
paper.
Furthermore,
covers
impact
parameters
on
yield
extracted
tannins,
possible
obstacles
directions
future
research
subject.
includes
challenges
such
high
viscosity,
intricated
recovery
compounds,
thermal
degradation,
occurrence
esterification.
An
extensive
summary
diversity,
structure,
biosynthesis,
distribution,
roles
plants
is
given
Additionally,
thoroughly
examines
bioactivities
metabolites.
Journal of Medicinal Chemistry,
Год журнала:
2024,
Номер
67(17), С. 14807 - 14819
Опубликована: Авг. 26, 2024
Deep
eutectic
solvents
(DES)
are
environmentally
friendly
with
the
potential
to
dissolve
bioactive
compounds
without
affecting
their
characteristics.
DES
has
special
qualities
that
can
be
customized
meet
unique
characteristics
of
a
biomolecule/active
pharmaceutical
ingredient
(API)
in
accordance
various
therapeutic
needs,
providing
reliable
approach
opening
door
for
creation
cutting-edge
drug
formulations
by
resolving
solubility
issues
pharmaceutics.
This
study
outlines
newly
developing
approaches
solve
problem
inefficient
API
extraction
due
poor
solubility.
These
emerging
strategies
also
have
capacity
alter
chemical
and
physical
stability
API,
which
triggers
drug's
shelf
life
possible
health
benefits.
It
is
anticipated
highlighted
methods
processes
will
developed
capitalize
on
improve
delivery
sector.
ACS Sustainable Chemistry & Engineering,
Год журнала:
2024,
Номер
12(18), С. 7187 - 7199
Опубликована: Апрель 24, 2024
Natural
deep
eutectic
solvents
(NaDES),
a
category
of
sustainable
made
from
biorefinery
ingredients,
are
an
eco-friendly
alternative
to
organic
in
solubilization
active
pharmaceutical
or
cosmetic
ingredients.
Biocompatible
NaDES
can
be
introduced
final
products
but
prone
modify
their
properties
thanks
hydrogen
bonding
capacities.
The
present
study
focuses
on
the
impact
incorporation
two
hydrophilic
betaine
and
glycerol
(BG)
citric
acid
glucose
(CG),
carboxymethylcellulose
(CMC)-based
hydrogel.
Differential
scanning
calorimetry
revealed
that
did
not
affect
endothermic
peak
water
eliminated
associated
with
CMC
polymer
chain
loosening.
Rheological
analysis
displayed
shear-thinning
behavior,
while
addition
10%
wt
led
significant
increase
viscosity
at
rest.
CG
introduction
shift
viscous-dominant
behavior
elastic-dominant
strengthening
cohesion
gel
structure.
Texture
analyses
NaDES-containing
gels
exhibit
higher
hardness
elasticity.
Sensory
evaluations
highlighted
differences
five
sensory
attributes
among
concentrations
types
playing
roles.
This
research
underscores
intricate
interplay
between
hydrogel
properties,
offering
insights
into
formulation
innovative
achieve
both
solubility
appeal.
International Journal of Pharmaceutics,
Год журнала:
2024,
Номер
661, С. 124418 - 124418
Опубликована: Июль 2, 2024
There
is
increasing
pharmaceutical
interest
in
deep
eutectic
solvents
not
only
as
a
green
alternative
to
organic
drug
manufacturing,
but
also
liquid
formulation
for
delivery.
The
present
work
introduces
hydrophobic
solvent
(HDES)
the
field
of
lipid-based
formulations
(LBF).
Phase
behavior
mixture
with
2:1
M
ratio
decanoic-
dodecanoic
acid
was
studied
experimentally
and
described
by
thermodynamic
modelling.
Venetoclax
selected
model
atomistic
molecular
dynamics
simulations
mixtures.
As
result,
valuable
insights
were
gained
into
interaction
networks
between
different
components.
Moreover,
HDES
showed
greatly
enhanced
solubilization
compared
conventional
glyceride-based
vehicles,
aqueous
dispersion
limited.
Hence
surfactants
their
ability
improve
addition
Tween
80
resulted
lowest
droplet
sizes
high
vitro
release.
In
conclusion,
combination
surfactant(s)
provides
novel
LBF
potential.
However,
components
must
be
finely
balanced
keep
integrity
solubilizing
HDES,
while
enabling
sufficient
Drug Development and Industrial Pharmacy,
Год журнала:
2024,
Номер
50(5), С. 387 - 400
Опубликована: Апрель 18, 2024
TheDES
are
formed
by
mixing
a
Hydrogen
Bond
Donor
(HBD)
and
Acceptor
(HBA)
in
appropriate
molar
ratios.
These
solvents
have
been
shown
to
enhance
drug
solubility,
permeability,
delivery.
The
main
objective
of
the
present
article
is
review
these
advantages
TheDES.
