Divergent Synthesis of Four Types of Fused N‐Containing Heterocycles via Oxidative Multi‐Component Cyclization Reaction
Chinese Journal of Chemistry,
Год журнала:
2025,
Номер
unknown
Опубликована: Янв. 31, 2025
Comprehensive
Summary
An
atmospheric‐oxygen‐mediated
four‐component
reaction
was
developed
for
the
divergent
synthesis
of
pyrazolo[1,5‐
a
]pyrimidine
and
pyrazolo[3,4‐
b
]pyridine
derivatives
from
readily
available
alcohols
3‐aminopyrazoles.
In
this
transformation,
atmospheric
oxygen
serves
as
green
oxidant,
promoting
equivalent
aldehydes
four
types
N
‐containing
heterocycles
(>
40
examples).
Remarkably,
transformation
features
metal‐free
molecular
diversity.
Язык: Английский
Manganese(I)-NNSe Pincer Complex Mediated Dehydrogenative Cyclization to Synthesize 2-Aryl-2,3-dihydroquinolin-4(1H)-ones
The Journal of Organic Chemistry,
Год журнала:
2025,
Номер
unknown
Опубликована: Фев. 28, 2025
A
catalytic
one-pot
cascade
dehydrogenative
cyclization
of
1-(2-aminophenyl)ethanone
using
primary
alcohols
is
presented.
The
reaction
catalyzed
by
an
earth-abundant
manganese
pincer
complex
NNSe
ligand,
without
any
solvent,
additives,
base,
or
hydrogen
acceptor,
liberating
dihydrogen
and
water
as
the
only
byproducts.
Compared
to
earlier
reported
four-step
coupling
protocol,
a
single
step
required
synthesize
2-aryl-2,3-dihydroquinolin-4(1H)-ones.
Язык: Английский
Cu–ABNO Catalyst for the Synthesis of Quinolines and Pyrazines via Aerobic Double Dehydrogenation of Alcohols
The Journal of Organic Chemistry,
Год журнала:
2024,
Номер
unknown
Опубликована: Ноя. 28, 2024
In
this
report,
a
new
imidazole-
and
amide-functionalized
pincer-like
Cu(II)
complex
(1)
was
synthesized
characterized.
By
employing
1
9-azabicyclo[3.3.1]nonane
NH-Oxyl
(ABNOH),
catalytic
protocol
for
alcohol
oxidation
the
subsequent
oxidation-triggered
synthesis
of
quinolines
pyrazines
were
explored.
Alcohols
such
as
2-aminoaryl
alcohols
also
oxidized
efficiently.
As
carbonyls
from
2-arylaminobenzyl
secondary
are
synthons
quinolines,
we
explored
their
directly
alcohols.
The
quite
efficient
completed
reaction
in
only
∼5–10
h.
Combinations
(a)
primary
with
or
ketones
(b)
found
to
be
very
effective
quinolines.
successful
various
1,2-diols
1,2-diaminobenzenes
10
Mechanistic
investigations
showed
that
generated
acted
an
active
catalyst:
it
activated
O2
subsequently
cooperation
N-Oxyl
(ABNO•)
α-CH
hydrogen
coordinated
alkoxide.
Then,
Cu(II)/Cu(I)
reduction
led
formation
carbonyl
compounds,
which
via
successive
C–C/C–N
coupling
reactions
resulted
heterocycles
presence
KOtBu
1.
Язык: Английский
Palygorskite-Mn(II): An efficient and recyclable heterogeneous catalyst for the synthesis of quinolines
Applied Clay Science,
Год журнала:
2024,
Номер
259, С. 107518 - 107518
Опубликована: Авг. 1, 2024
Язык: Английский
Activating Methanol for Chemoselective Transfer Hydrogenation of Chalcones using SNS-Ru Complex
Synlett,
Год журнала:
2024,
Номер
35(20), С. 2429 - 2434
Опубликована: Авг. 12, 2024
Abstract
Methanol
is
gaining
popularity
as
a
transfer-hydrogenating
agent
in
catalytic
reduction
reactions
because
of
its
bulk-scale
production
and
inexpensive
nature.
Current
research
interests
include
the
utilization
methanol
safe
sustainable
hydrogen
source
for
chemical
synthesis
drug
development.
In
particular,
chemoselective
α,β-unsaturated
ketones
great
interest
their
prevalence
many
natural
products.
We
investigated
potential
application
acridine-derived
SNS-Ru
pincer
complexes
activation
chalcones.
Our
developed
system
showed
broad
substrate
tolerance,
including
substrates
containing
reducible
functional
groups.
Control
experiments
postsynthetic
applications
are
also
highlighted.
Язык: Английский