Recent developments in intranasal drug delivery of nanomedicines for the treatment of neuropsychiatric disorders

Frontiers in Medicine, Год журнала: 2024, Номер 11

Опубликована: Сен. 19, 2024

Neuropsychiatric disorders are multifaceted syndromes with confounding neurological explanations. It includes anxiety, depression, autism spectrum disorder, attention deficit hyperactivity schizophrenia, Tourette’s syndrome, delirium, dementia, vascular cognitive impairment, and apathy etc. Globally, these occupy 15% of all diseases. As per the WHO, India has one largest populations people mental illnesses worldwide. The blood-brain barrier (BBB) makes it extremely difficult to distribute medicine target cells in brain tissues. However, is possible through novel advancements nanotechnology, molecular biology, neurosciences. One such cutting-edge delivery method, nose-to-brain (N2B) drug using nanoformulation (NF), overcomes traditional formulation limitations. Later offers more controlled release, better bioavailability, improved patient acceptance, reduced biological interference, circumvention BBB. When medicines delivered via intranasal (IN) route, they enter nasal cavity go connections between olfactory trigeminal nerves mucosa N2B. Delivering phytochemical, bioactive synthetic NF being investigated N2B strategy. mucociliary clearance, enzyme degradation, translocations by efflux mechanisms significant issues associated delivery. This review article discusses types neuropsychiatric their treatment plant-derived as well drug-loaded NFs administered IN-delivery system. In conclusion, this provided a comprehensive critical overview IN applicability for psychiatric disorders.

Язык: Английский

---

Nanosystems for targeted drug Delivery: Innovations and challenges in overcoming the Blood-Brain barrier for neurodegenerative disease and cancer therapy

International Journal of Pharmaceutics, Год журнала: 2024, Номер 666, С. 124800 - 124800

Опубликована: Окт. 5, 2024

Язык: Английский

---

In-depth Mechanism, Challenges, and Opportunities of Delivering Therapeutics in Brain Using Intranasal Route

AAPS PharmSciTech, Год журнала: 2024, Номер 25(5)

Опубликована: Май 6, 2024

Язык: Английский

---

Unveiling the Therapeutic Potential of Folate-Dependent One-Carbon Metabolism in Cancer and Neurodegeneration

International Journal of Molecular Sciences, Год журнала: 2024, Номер 25(17), С. 9339 - 9339

Опубликована: Авг. 28, 2024

Cellular metabolism is crucial for various physiological processes, with folate-dependent one-carbon (1C) playing a pivotal role. Folate, B vitamin, key cofactor in this pathway, supporting DNA synthesis, methylation and antioxidant defenses. In dividing cells, folate facilitates nucleotide biosynthesis, ensuring genomic stability preventing carcinogenesis. Additionally, neurodevelopment, essential neural tube closure central nervous system formation. Thus, dysregulation of can contribute to pathologies such as cancer, severe birth defects, neurodegenerative diseases. Epidemiological evidence highlights folate's impact on disease risk its potential therapeutic target. antifolate drugs that inhibit enzymes 1C strategies targeting receptors are current options. However, cancer complex, varying among types dietary contexts. conditions, including Alzheimer's Parkinson's diseases, deficiency exacerbates cognitive decline through elevated homocysteine levels, contributing neuronal damage. Clinical trials folic acid supplementation show mixed outcomes, underscoring the complexities neuroprotective effects. This review integrates knowledge neurodegeneration, exploring molecular mechanisms, clinical implications, strategies, which provide information advancing treatments.

Язык: Английский

---

Therapeutic Delivery of circDYM by Perillyl Alcohol Nanoemulsion Alleviates LPS‐Induced Depressive‐Like Behaviors

Advanced Science, Год журнала: 2025, Номер unknown

Опубликована: Март 27, 2025

Abstract RNA therapeutics have recently shown significant promise in treating a variety of diseases, including cancers, infectious and genetic disorders. However, their potential addressing neuropsychiatric disorders has been limited by the lack an efficient delivery system to central nervous (CNS). Here, novel nanoemulsion platform, perillyl alcohol nanoemulsions (PANEs) is introduced, designed for therapeutic circDYM brain alleviated depressive‐like behaviors. PANEs successfully encapsulated using cationic lipid compositions, enhancing its efficiency mouse via phase. The optimized formulation, PANE2‐4, significantly improved compared both free standard nanoparticle formulations. Intranasal administration PANE2‐4‐circDYM effectively behaviors LPS‐induced model depression. This effect achieved reducing CD11b + CD45 dim microglia population iNOS expression, restoring expression protein‐95 (PSD‐95) synaptophysin. These findings indicated that PANE represents platform delivering circRNAs brain, intranasal promising strategy ameliorating

Язык: Английский

---

Intranasal Delivery of Anti-Apoptotic siRNA Complexed with Fas-Signaling Blocking Peptides Attenuates Cellular Apoptosis in Brain Ischemia

Pharmaceutics, Год журнала: 2024, Номер 16(2), С. 290 - 290

Опубликована: Фев. 18, 2024

Ischemic stroke-induced neuronal cell death leads to the permanent impairment of brain function. The Fas-mediating extrinsic apoptosis pathway and cytochrome c-mediating intrinsic are two major molecular mechanisms contributing injury in ischemic stroke. In this study, we employed a Fas-blocking peptide (FBP) coupled with positively charged nona-arginine (9R) form complex negatively siRNA targeting Bax (FBP9R/siBax). This is specifically designed deliver Fas-expressing cells. enables targeted inhibition pathways pathways. Specifically, FBP targets Fas/Fas ligand signaling, while siBax involved mitochondria disruption pathway. FBP9R carrier system delivery functional hypoxic cells expressing Fas receptor on their surface—a finding validated through qPCR confocal microscopy analyses. Through intranasal (IN) administration FBP9R/siCy5 middle cerebral artery occlusion (MCAO) rat models, imaging revealed localized infarcted region but did not localize non-infarcted brain. A single IN FBP9R/siBax demonstrated significant reduction by effectively inhibiting signaling preventing release c. represents promising alternative strategy for treatment ischemia.

Язык: Английский

---

Critical Challenges of Intravenous Nanomaterials Crossing the Blood‐Brain Barrier: from Blood to Brain

Advanced Functional Materials, Год журнала: 2024, Номер unknown

Опубликована: Дек. 17, 2024

Abstract Despite recent advancements in the development of blood‐brain barrier (BBB)‐crossing nanomaterials for intravenous administration, there have been very few successful cases clinical trials. Ongoing challenges within body impede precise therapeutic effects these from reaching their intended target area. Therefore, a comprehensive analysis entire pathway that BBB‐crossing must traverse‐from bloodstream to brain‐along with an understanding obstacles encountered along way, is essential advancing materials This review begins brief overview structure and function BBB, as well pathways strategies crossing it. Next, it discussed analyzed common sites brain bloodstream. To address challenges, “eight‐step” guideline strategy proposed. By leveraging principles precision medicine, design customization cascade‐targeted can overcome multiple show promise future trials practical applications. Finally, perspective on direction this field offered.

Язык: Английский

---

Nanotechnology used for siRNA delivery for the treatment of neurodegenerative diseases: Focusing on Alzheimer’s disease and Parkinson’s disease

International Journal of Pharmaceutics, Год журнала: 2024, Номер 666, С. 124786 - 124786

Опубликована: Окт. 6, 2024

Язык: Английский

---