Bridging epigenomics and tumor immunometabolism: molecular mechanisms and therapeutic implications
Molecular Cancer,
Год журнала:
2025,
Номер
24(1)
Опубликована: Март 8, 2025
Epigenomic
modifications—such
as
DNA
methylation,
histone
acetylation,
and
methylation—and
their
implications
in
tumorigenesis,
progression,
treatment
have
emerged
a
pivotal
field
cancer
research.
Tumors
undergo
metabolic
reprogramming
to
sustain
proliferation
metastasis
nutrient-deficient
conditions,
while
suppressing
anti-tumor
immunity
the
tumor
microenvironment
(TME).
Concurrently,
immune
cells
within
immunosuppressive
TME
adaptations,
leading
alterations
function.
The
complicated
interplay
between
metabolites
epigenomic
modulation
has
spotlighted
significance
of
regulation
immunometabolism.
In
this
review,
characteristics
modification
associated
with
tumors
are
systematically
summarized
alongside
regulatory
roles
Classical
emerging
approaches
delineated
broaden
boundaries
research
on
crosstalk
immunometabolism
epigenomics.
Furthermore,
we
discuss
potential
therapeutic
strategies
that
target
modulate
modifications,
highlighting
burgeoning
synergy
therapies
immunotherapy
promising
avenue
for
treatment.
Язык: Английский
Serine metabolism in tumor progression and immunotherapy
Discover Oncology,
Год журнала:
2025,
Номер
16(1)
Опубликована: Апрель 28, 2025
Язык: Английский
Recent updates in the therapeutic uses of Pembrolizumab: a brief narrative review
Clinical & Translational Oncology,
Год журнала:
2024,
Номер
26(10), С. 2431 - 2443
Опубликована: Апрель 24, 2024
Язык: Английский
One-carbon metabolism shapes T cell immunity in cancer
Trends in Endocrinology and Metabolism,
Год журнала:
2024,
Номер
35(11), С. 967 - 980
Опубликована: Июнь 25, 2024
Язык: Английский
Proteomic analysis reveals immune-related proteins of coelomic fluid in Urechis unicinctus
Comparative Biochemistry and Physiology Part D Genomics and Proteomics,
Год журнала:
2025,
Номер
54, С. 101427 - 101427
Опубликована: Янв. 24, 2025
Язык: Английский
One-carbon metabolism is distinct metabolic signature for proliferative intermediate exhausted T cells of ICB-resistant cancer patients
Cell Death Discovery,
Год журнала:
2025,
Номер
11(1)
Опубликована: Фев. 14, 2025
Abstract
One-carbon
metabolism
(1CM)
has
been
reported
to
promote
cancer
progression
across
various
malignancies.
While
1CM
is
critical
for
cell
proliferation
by
enhancing
nucleotide
synthesis,
its
physiological
roles
within
different
types
in
the
tumor
immune
microenvironment
(TIME)
still
remain
unclear.
In
this
study,
we
analyzed
bulk-RNA
sequencing
and
single-cell
RNA
(scRNA-seq)
data
from
lung
adenocarcinoma
(LUAD)
patients
elucidate
functional
of
TIME.
Moreover,
examined
scRNA-seq
treated
with
immunotherapy
cancers,
including
LUAD,
glioblastoma,
renal
carcinoma,
colorectal
cancer,
triple-negative
breast
cancer.
Compared
other
types,
gene
profiles
are
significantly
enriched
a
specific
subset
T
cells.
Intriguingly,
these
high-1CM
cells
identified
as
proliferative
intermediate
exhausted
(Tex
int
).
Furthermore,
Tex
received
most
robust
CD137
signaling.
Consistently,
analysis
LUAD
undergoing
anti-PD1
demonstrated
that
exhibited
higher
scores
increased
This
observation
was
particularly
pronounced
non-responders
immunotherapy,
where
population
expanded.
We
further
established
prominent
signaling
pathway
resistant
multiple
types.
Collectively,
identify
distinctive
who
do
not
respond
immunotherapy.
These
findings
propose
targeting
may
represent
novel
therapeutic
strategy
enhance
efficacy
mitigating
diverse
cancers.
Язык: Английский
Advances in the Study of Metabolic Reprogramming in Gastric Cancer
Cancer Medicine,
Год журнала:
2025,
Номер
14(10)
Опубликована: Май 1, 2025
ABSTRACT
Background
Gastric
cancer
is
one
of
the
most
prevalent
malignancies
digestive
system
and
associated
with
a
poor
prognosis,
particularly
in
advanced
metastatic
stages,
where
5‐year
survival
rate
significantly
low.
Methods
Recent
research
has
demonstrated
that
metabolic
reprogramming—including
alterations
glucose,
lipid,
amino‐acid
metabolism—plays
critical
role
both
development
progression
this
disease.
To
gain
deeper
insights
into
these
shifts,
scientists
have
increasingly
employed
metabolomics,
non‐invasive
technique
detects
quantifies
small
molecules
within
cancerous
tissues,
thereby
enhancing
prognostic
assessments.
Aim
Analyzing
profiles
gastric‐cancer
tissues
can
reveal
significant
changes
key
pathways,
which
may
open
new
avenues
for
targeted
therapies
ultimately
improve
patient
outcomes.
Conclusion
This
article
reviews
recent
advancements
study
reprogramming
gastric
cancer,
aiming
to
identify
potential
therapeutic
targets
offer
hope
patients.
Язык: Английский
FOLR2+ macrophages in cancer: allies or enemies
Cell Communication and Signaling,
Год журнала:
2025,
Номер
23(1)
Опубликована: Июнь 2, 2025
The
advent
of
the
omics
era
has
facilitated
identification
precise
biomarkers
for
cancer
progression,
revealing
a
broader
diversity
macrophage
phenotypes
beyond
traditional
M1/M2
classification.
Folate
receptor
2
(FOLR2)-positive
macrophages,
co-expressing
markers
such
as
mannose
C-Type
1
(MRC1/CD206)
and
lymphatic
vessel
endothelial
hyaluronan
1(LYVE1),
are
an
embryonically
derived
subset
typically
found
around
blood
vessels
in
both
tumor
stroma
normal
tissues.
Despite
FOLR2's
longstanding
association
with
anti-inflammatory,
immunosuppressive
macrophages
tumors,
its
role
progression
remains
unclear.
Recent
studies
suggest
that
FOLR2+
can
either
promote
or
inhibit
depending
on
their
multifaceted
roles
microenvironment.
This
review
provides
comprehensive
overview
biological
features,
functional
roles,
molecular
mechanisms,
therapeutic
potential
cancer.
Язык: Английский
Folic Acid Deficiency
Advances in medical diagnosis, treatment, and care (AMDTC) book series,
Год журнала:
2024,
Номер
unknown, С. 116 - 164
Опубликована: Июнь 14, 2024
Folic
acid
deficiency,
a
critical
global
health
issue,
significantly
impacts
various
population
groups,
particularly
pregnant
women
and
individuals
with
dietary
restrictions.
This
chapter
provides
an
in-depth
analysis
of
folic
focusing
on
its
epidemiology,
causes,
clinical
manifestations,
including
megaloblastic
anemia
developmental
complications.
It
underscores
the
crucial
role
in
human
physiology,
notably
DNA
synthesis
repair.
Additionally,
discusses
complex
nature
which
encompasses
inadequacies,
malabsorption
issues,
medication
interactions,
confronts
challenges
diagnosis.
Management
strategies
such
as
modifications,
supplementation,
public
policies,
fortification,
are
thoroughly
examined.
In
conclusion,
multifaceted
approach
is
vital
for
mitigating
impact
deficiency
enhancing
outcomes.
Язык: Английский