Angiogenesis and targeted therapy in the tumour microenvironment: From basic to clinical practice

Clinical and Translational Medicine, Год журнала: 2025, Номер 15(4)

Опубликована: Апрель 1, 2025

Abstract Angiogenesis, as a core marker of cancer survival and growth, is integral to the processes tumour invasion metastasis. In recent years, targeted angiogenesis treatment strategies have gradually become an important direction in treatment. Single‐cell sequencing technology can provide new insights into by providing deeper understanding heterogeneity endothelial cells exploring interactions between surrounding microenvironment. Here, we systematically review research progress cell pathophysiology its endothelial‒mesenchymal transition illustrate from single‐cell perspective. Finally, examine contributions different types within microenvironment relation angiogenesis, well latest therapy, hoping useful clinical application antiangiogenic Furthermore, summary present development potential inhibitors ongoing trials for combination therapies provided. Key points Angiogenesis plays key role progression, metastasis, so targeting are becoming therapy. Interactions stromal immune significant angiogenesis. The immunotherapy nanotechnology therapy provides vital strategy prolonging patients.

Язык: Английский

Targeting the Senescent Tumor Microenvironment to Sensitize Immunotherapy

Highlights in Science Engineering and Technology, Год журнала: 2025, Номер 139, С. 260 - 271

Опубликована: Апрель 28, 2025

The tumor microenvironment (TME) plays a pivotal role in cancer progression, metastasis, and therapeutic resistance. Cellular senescence within the TME, characterized by irreversible growth arrest senescence-associated secretory phenotype (SASP), profoundly impacts biology immunotherapy efficacy. senescent TME promotes growth, invasion, metastasis through complex interactions between cells, SASP factors, extracellular matrix (ECM). Simultaneously, senescence-induced alterations immune cell function, including T exhaustion, macrophage polarization, impaired natural killer (NK) cytotoxicity, contribute to an immunosuppressive niche that hinders immunosurveillance fosters evasion. Mounting evidence suggests is critical mediator of resistance checkpoint inhibitors (ICIs). Senescence-associated changes dampen antitumor immunity reducing CD8+ infiltration functionality while promoting accumulation populations such as regulatory cells (Tregs) myeloid-derived suppressor (MDSCs). Consequently, strategies targeting have emerged promising approaches enhance ICI Senolytic agents, inhibitors, combinatorial therapies aimed at eliminating modulating SASP, reprogramming shown potential preclinical models sensitize tumors immunotherapy. As our understanding evolves, it becoming increasingly clear multifaceted approach integrating TME-targeted interventions with necessary overcome improve patient outcomes. Future research should focus on elucidating molecular mechanisms underlying senescence-driven resistance, identifying robust biomarkers predict treatment response, developing novel synergize ICIs. By harnessing approaches, we can expand scope efficacy immunotherapy, ultimately leading improved survival quality life for patients.

Язык: Английский

Biology, Genetics and Molecular Aspects of Aging

IGI Global eBooks, Год журнала: 2025, Номер unknown, С. 67 - 94

Опубликована: Апрель 25, 2025

Aging is a complicated process influenced by various factors that disturb cellular function and alter organism equilibrium over time. This chapter provides an updated overview, focusing on mechanisms like genomic instability, telomere attrition, mitochondrial failure, DNA damage buildup. Cellular senescence addressed in age-related illnesses, highlighting irreversible cell cycle arrest pro-inflammatory aspects. Epigenetic processes, specifically methylation inherited histone modifications, contribute to phenotypes. Longevity research covers FOXO, SIRT, autophagy. Nutrient-sensing pathways the microbiome's role aging are explored, along with therapeutic interventions targeting these pathways. synthesis of recent discoveries genetics, molecular biology, translational comprehensive perspective biology future clinical applications. By integrating insights from fields, this aims develop innovative strategies promote healthy longevity.

Язык: Английский