Frontiers in Pharmacology,
Год журнала:
2022,
Номер
13
Опубликована: Ноя. 8, 2022
One
of
the
main
obstacles
to
most
medication
administrations
(such
as
vaccine
constructs)
is
cellular
membrane’s
inadequate
permeability,
which
reduces
their
efficiency.
Cell-penetrating
peptides
(CPPs)
or
protein
transduction
domains
(PTDs)
are
well-known
potent
biological
nanocarriers
overcome
this
natural
barrier,
and
deliver
membrane-impermeable
substances
into
cells.
The
physicochemical
properties
CPPs,
attached
cargo,
concentration,
cell
type
substantially
influence
internalization
mechanism.
Although
exact
mechanism
uptake
following
processing
CPPs
still
uncertain;
but
however,
they
can
facilitate
intracellular
transfer
through
both
endocytic
non-endocytic
pathways.
Improved
endosomal
escape
efficiency,
selective
targeting,
improved
uptake,
processing,
presentation
antigen
by
antigen-presenting
cells
(APCs)
have
been
reported
CPPs.
Different
in
vitro
vivo
investigations
using
CPP
conjugates
show
potential
therapeutic
agents
various
medical
areas
such
infectious
non-infectious
disorders.
Effective
treatments
for
a
variety
diseases
may
be
provided
vaccines
that
cooperatively
stimulate
T
cell-mediated
immunity
(T
helper
activity
cytotoxic
function),
immunologic
memory.
Delivery
epitopes
APCs,
generation
immune
response
essential
an
efficacious
facilitated
current
review
describes
delivery
numerous
components
immunostimulatory
properties.
Polymers,
Год журнала:
2023,
Номер
15(5), С. 1160 - 1160
Опубликована: Фев. 25, 2023
Self-assembly
is
a
growth
mechanism
in
nature
to
apply
local
interactions
forming
minimum
energy
structure.
Currently,
self-assembled
materials
are
considered
for
biomedical
applications
due
their
pleasant
features,
including
scalability,
versatility,
simplicity,
and
inexpensiveness.
Self-assembled
peptides
can
be
applied
design
fabricate
different
structures,
such
as
micelles,
hydrogels,
vesicles,
by
diverse
physical
between
specific
building
blocks.
Among
them,
bioactivity,
biocompatibility,
biodegradability
of
peptide
hydrogels
have
introduced
them
versatile
platforms
applications,
drug
delivery,
tissue
engineering,
biosensing,
treating
diseases.
Moreover,
capable
mimicking
the
microenvironment
natural
tissues
responding
internal
external
stimuli
triggered
release.
In
current
review,
unique
characteristics
recent
advances
design,
fabrication,
well
chemical,
physical,
biological
properties
presented.
Additionally,
developments
these
biomaterials
discussed
with
particular
focus
on
targeted
delivery
gene
stem
cell
therapy,
cancer
therapy
immune
regulation,
bioimaging,
regenerative
medicine.
International Journal of Nanomedicine,
Год журнала:
2023,
Номер
Volume 18, С. 7605 - 7635
Опубликована: Дек. 1, 2023
Small
interfering
RNA
(siRNA)
delivery
by
nanocarriers
has
been
identified
as
a
promising
strategy
in
the
study
and
treatment
of
cancer.
Short
nucleotide
sequences
are
synthesized
exogenously
to
create
siRNA,
which
triggers
interference
(RNAi)
cells
silences
target
gene
expression
sequence-specific
way.
As
nucleic
acid-based
medicine
that
gained
popularity
recently,
siRNA
exhibits
novel
potential
for
However,
there
still
many
obstacles
overcome
before
clinical
devices
can
be
developed.
In
this
review,
we
discuss
prospective
targets
drug
design,
explain
properties
benefits,
give
an
overview
current
therapeutics
Additionally,
introduce
chemical
modifications
systems
clinically
sophisticated
classify
bioresponsive
materials
release
methodical
manner.
This
review
will
serve
reference
researchers
developing
more
precise
efficient
targeted
systems,
promoting
ongoing
advances
applications.
International Journal of Molecular Sciences,
Год журнала:
2024,
Номер
25(2), С. 815 - 815
Опубликована: Янв. 9, 2024
Drugs
based
on
peptides
and
proteins
(PPs)
have
been
widely
used
in
medicine,
beginning
with
insulin
therapy
patients
diabetes
mellitus
over
a
century
ago.
Although
the
oral
route
of
drug
administration
is
preferred
one
by
vast
majority
improves
compliance,
medications
this
kind
due
to
their
specific
chemical
structure
are
typically
delivered
parenterally,
which
ensures
optimal
bioavailability.
In
order
overcome
issues
connected
absorption
PPs
such
as
instability
depending
digestive
enzymes
pH
changes
gastrointestinal
(GI)
system
hand,
but
also
limited
permeability
across
physiological
barriers
(mucus
epithelium)
other
scientists
strenuously
searching
for
novel
delivery
methods
enabling
peptide
protein
drugs
(PPDs)
be
administered
enterally.
These
include
utilization
different
nanoparticles,
transport
channels,
substances
enhancing
permeation,
modifications,
hydrogels,
microneedles,
microemulsion,
proteolytic
enzyme
inhibitors,
cell-penetrating
peptides,
all
extensively
discussed
review.
Furthermore,
article
highlights
PP
therapeutics
both
previously
currently
available
medical
market.
Nucleosides Nucleotides & Nucleic Acids,
Год журнала:
2025,
Номер
unknown, С. 1 - 25
Опубликована: Янв. 13, 2025
The
field
of
biomedical
science
has
witnessed
another
milestone
with
the
advent
RNA-based
therapeutics.
This
review
explores
three
major
RNA
molecules,
namely:
messenger
(mRNA),
interference
technology
(RNAi),
and
Antisense
Oligonucleotide
(ASO),
analyses
U.S.
Food
Drug
Administration
drugs
from
14
pharmaceutical
companies
in
terms
targeted
genes,
diseases
types,
clinical
trials
status,
mode
delivery,
year
production.
Many
such
are
clinically
approved
or
pending
approval
by
(FDA)
alongside
other
leading
agencies.
Regarding
diseases,
this
article
emphasizes
cancer
therapy,
genetic
viral
infections,
two
categories
drug
delivery
systems
include
vectors
nanoparticles.
Despite
tremendous
progress
made,
key
issues
associated
these
stability,
off-target
activities
payloads,
efficiency
cellular
uptake,
innovative
need
for
engineering
techniques
modifications.
transformative
potential
therapeutics
role
technologies
addressing
needs,
paving
way
a
new
era
precision
medicine.
Cancers,
Год журнала:
2022,
Номер
14(22), С. 5546 - 5546
Опубликована: Ноя. 11, 2022
Cell-Penetrating
Peptides
(CPPs)
are
short
peptides
consisting
of
<30
amino
acids.
Their
ability
to
translocate
through
the
cell
membrane
while
carrying
large
cargo
biomolecules
has
been
topic
pre-clinical
and
clinical
trials.
The
deliver
complexes
membranes
yields
potential
for
therapeutics
diagnostics
diseases
such
as
cancer.
Upon
cellular
entry,
some
CPPs
have
target
specific
organelles.
CPP-based
intracellular
targeting
strategies
hold
tremendous
they
can
improve
efficacy
reduce
toxicities
side
effects.
Further,
recent
trials
show
a
significant
future
cancer
treatment.
In
this
review,
we
summarize
advances
in
based
on
systematic
searches
PubMed,
Embase,
Web
Science,
Scopus
databases
until
30
September
2022.
We
highlight
targeted
delivery
explore
uses
diagnostics,
drug
delivery,
intrinsic
anti-cancer
agents.
Abstract
Intracellular
delivery
of
nano‐drug‐carriers
(NDC)
to
specific
cells,
diseased
regions,
or
solid
tumors
has
entered
the
era
precision
medicine
that
requires
systematic
knowledge
nano‐biological
interactions
from
multidisciplinary
perspectives.
To
this
end,
review
first
provides
an
overview
membrane‐disruption
methods
such
as
electroporation,
sonoporation,
photoporation,
microfluidic
delivery,
and
microinjection
with
merits
high‐throughput
enhanced
efficiency
for
in
vitro
NDC
delivery.
The
impact
characteristics
including
particle
size,
shape,
charge,
hydrophobicity,
elasticity
on
cellular
uptake
are
elaborated
several
types
systems
aiming
hierarchical
targeting
vivo
reviewed.
Emerging
ex
human/animal‐derived
pathophysiological
models
further
explored
highly
recommended
use
studies
since
they
might
mimic
features
fill
translational
gaps
animals
humans.
exploration
modern
microscopy
techniques
precise
nanoparticle
(NP)
tracking
at
cellular,
organ,
organismal
levels
informs
tailored
development
NDCs
application
clinical
translation.
Overall,
integrates
latest
insights
into
smart
nanosystem
engineering,
physiological
models,
imaging‐based
validation
tools,
all
directed
towards
enhancing
efficient
intracellular
NDCs.
ACS Nano,
Год журнала:
2024,
Номер
18(26), С. 16359 - 16394
Опубликована: Июнь 11, 2024
Glioblastoma
(GBM)
remains
the
epitome
of
aggressiveness
and
lethality
in
spectrum
brain
tumors,
primarily
due
to
blood–brain
barrier
(BBB)
that
hinders
effective
treatment
delivery,
tumor
heterogeneity,
presence
treatment-resistant
stem
cells
contribute
recurrence.
Nanoparticles
(NPs)
have
been
used
overcome
these
obstacles
by
attaching
targeting
ligands
enhance
therapeutic
efficacy.
Among
ligands,
peptides
stand
out
their
ease
synthesis
high
selectivity.
This
article
aims
review
single
multiligand
strategies
critically.
In
addition,
it
highlights
other
integrate
effects
external
stimuli,
biomimetic
approaches,
chemical
approaches
as
nanocatalytic
medicine,
revealing
significant
potential
treating
GBM
with
peptide-functionalized
NPs.
Alternative
routes
parenteral
administration,
specifically
nose-to-brain
delivery
local
within
resected
cavity,
are
also
discussed.
Finally,
an
overview
them
discussed
provide
a
perspective
on
this
promising
field
therapy.
Pharmaceutics,
Год журнала:
2024,
Номер
16(2), С. 240 - 240
Опубликована: Фев. 6, 2024
Effective
drug
delivery
is
essential
for
cancer
treatment.
Drug
systems,
which
can
be
tailored
to
targeted
transport
and
integrated
tumor
therapy,
are
vital
in
improving
the
efficiency
of
Peptides
play
a
significant
role
various
biological
physiological
functions
offer
high
design
flexibility,
excellent
biocompatibility,
adjustable
morphology,
biodegradability,
making
them
promising
candidates
delivery.
This
paper
reviews
peptide-mediated
focusing
on
self-assembled
peptides
peptide–drug
conjugates.
It
discusses
mechanisms
structural
control
peptides,
varieties
roles
conjugates,
strategies
augment
peptide
stability.
The
review
concludes
by
addressing
challenges
future
directions.
