Cell penetrating peptide: A potent delivery system in vaccine development DOI Creative Commons
Behnam Hasannejad-Asl,

Farkhondeh Pooresmaeil,

Shahla Takamoli

и другие.

Frontiers in Pharmacology, Год журнала: 2022, Номер 13

Опубликована: Ноя. 8, 2022

One of the main obstacles to most medication administrations (such as vaccine constructs) is cellular membrane’s inadequate permeability, which reduces their efficiency. Cell-penetrating peptides (CPPs) or protein transduction domains (PTDs) are well-known potent biological nanocarriers overcome this natural barrier, and deliver membrane-impermeable substances into cells. The physicochemical properties CPPs, attached cargo, concentration, cell type substantially influence internalization mechanism. Although exact mechanism uptake following processing CPPs still uncertain; but however, they can facilitate intracellular transfer through both endocytic non-endocytic pathways. Improved endosomal escape efficiency, selective targeting, improved uptake, processing, presentation antigen by antigen-presenting cells (APCs) have been reported CPPs. Different in vitro vivo investigations using CPP conjugates show potential therapeutic agents various medical areas such infectious non-infectious disorders. Effective treatments for a variety diseases may be provided vaccines that cooperatively stimulate T cell-mediated immunity (T helper activity cytotoxic function), immunologic memory. Delivery epitopes APCs, generation immune response essential an efficacious facilitated current review describes delivery numerous components immunostimulatory properties.

Язык: Английский

The role of cell‐penetrating peptides in potential anti‐cancer therapy DOI
Meiling Zhou,

Zou Xi,

Kexin Cheng

и другие.

Clinical and Translational Medicine, Год журнала: 2022, Номер 12(5)

Опубликована: Май 1, 2022

Язык: Английский

Процитировано

89

Multifunctional Self-Assembled Peptide Hydrogels for Biomedical Applications DOI Open Access
Mahsa Sedighi, Neha Shrestha, Zahra Mahmoudi

и другие.

Polymers, Год журнала: 2023, Номер 15(5), С. 1160 - 1160

Опубликована: Фев. 25, 2023

Self-assembly is a growth mechanism in nature to apply local interactions forming minimum energy structure. Currently, self-assembled materials are considered for biomedical applications due their pleasant features, including scalability, versatility, simplicity, and inexpensiveness. Self-assembled peptides can be applied design fabricate different structures, such as micelles, hydrogels, vesicles, by diverse physical between specific building blocks. Among them, bioactivity, biocompatibility, biodegradability of peptide hydrogels have introduced them versatile platforms applications, drug delivery, tissue engineering, biosensing, treating diseases. Moreover, capable mimicking the microenvironment natural tissues responding internal external stimuli triggered release. In current review, unique characteristics recent advances design, fabrication, well chemical, physical, biological properties presented. Additionally, developments these biomaterials discussed with particular focus on targeted delivery gene stem cell therapy, cancer therapy immune regulation, bioimaging, regenerative medicine.

Язык: Английский

Процитировано

60

A Comprehensive Review of Small Interfering RNAs (siRNAs): Mechanism, Therapeutic Targets, and Delivery Strategies for Cancer Therapy DOI Creative Commons
Jiaying Zhang, Bo Chen, Chunyuan Gan

и другие.

International Journal of Nanomedicine, Год журнала: 2023, Номер Volume 18, С. 7605 - 7635

Опубликована: Дек. 1, 2023

Small interfering RNA (siRNA) delivery by nanocarriers has been identified as a promising strategy in the study and treatment of cancer. Short nucleotide sequences are synthesized exogenously to create siRNA, which triggers interference (RNAi) cells silences target gene expression sequence-specific way. As nucleic acid-based medicine that gained popularity recently, siRNA exhibits novel potential for However, there still many obstacles overcome before clinical devices can be developed. In this review, we discuss prospective targets drug design, explain properties benefits, give an overview current therapeutics Additionally, introduce chemical modifications systems clinically sophisticated classify bioresponsive materials release methodical manner. This review will serve reference researchers developing more precise efficient targeted systems, promoting ongoing advances applications.

Язык: Английский

Процитировано

54

The Current and Promising Oral Delivery Methods for Protein- and Peptide-Based Drugs DOI Open Access
Michał Nicze, Maciej Borówka,

Adrianna Dec

и другие.

International Journal of Molecular Sciences, Год журнала: 2024, Номер 25(2), С. 815 - 815

Опубликована: Янв. 9, 2024

Drugs based on peptides and proteins (PPs) have been widely used in medicine, beginning with insulin therapy patients diabetes mellitus over a century ago. Although the oral route of drug administration is preferred one by vast majority improves compliance, medications this kind due to their specific chemical structure are typically delivered parenterally, which ensures optimal bioavailability. In order overcome issues connected absorption PPs such as instability depending digestive enzymes pH changes gastrointestinal (GI) system hand, but also limited permeability across physiological barriers (mucus epithelium) other scientists strenuously searching for novel delivery methods enabling peptide protein drugs (PPDs) be administered enterally. These include utilization different nanoparticles, transport channels, substances enhancing permeation, modifications, hydrogels, microneedles, microemulsion, proteolytic enzyme inhibitors, cell-penetrating peptides, all extensively discussed review. Furthermore, article highlights PP therapeutics both previously currently available medical market.

Язык: Английский

Процитировано

20

Innovations in RNA therapeutics: a review of recent advances and emerging technologies DOI
Tuward J. Dweh,

Glay Jr Eric Wulu,

John Kessellie Jallah

и другие.

Nucleosides Nucleotides & Nucleic Acids, Год журнала: 2025, Номер unknown, С. 1 - 25

Опубликована: Янв. 13, 2025

The field of biomedical science has witnessed another milestone with the advent RNA-based therapeutics. This review explores three major RNA molecules, namely: messenger (mRNA), interference technology (RNAi), and Antisense Oligonucleotide (ASO), analyses U.S. Food Drug Administration drugs from 14 pharmaceutical companies in terms targeted genes, diseases types, clinical trials status, mode delivery, year production. Many such are clinically approved or pending approval by (FDA) alongside other leading agencies. Regarding diseases, this article emphasizes cancer therapy, genetic viral infections, two categories drug delivery systems include vectors nanoparticles. Despite tremendous progress made, key issues associated these stability, off-target activities payloads, efficiency cellular uptake, innovative need for engineering techniques modifications. transformative potential therapeutics role technologies addressing needs, paving way a new era precision medicine.

Язык: Английский

Процитировано

3

Bacterial Systems as a Precision Delivery Platform of Therapeutic Peptides for Cancer Therapy DOI Creative Commons
Jinyuan Liu, Guizhi Shen, Xuehai Yan

и другие.

Polymer science & technology., Год журнала: 2025, Номер unknown

Опубликована: Фев. 5, 2025

Язык: Английский

Процитировано

3

Cell-Penetrating Peptides (CPPs) as Therapeutic and Diagnostic Agents for Cancer DOI Open Access

Ryan A. Bottens,

Tohru Yamada

Cancers, Год журнала: 2022, Номер 14(22), С. 5546 - 5546

Опубликована: Ноя. 11, 2022

Cell-Penetrating Peptides (CPPs) are short peptides consisting of <30 amino acids. Their ability to translocate through the cell membrane while carrying large cargo biomolecules has been topic pre-clinical and clinical trials. The deliver complexes membranes yields potential for therapeutics diagnostics diseases such as cancer. Upon cellular entry, some CPPs have target specific organelles. CPP-based intracellular targeting strategies hold tremendous they can improve efficacy reduce toxicities side effects. Further, recent trials show a significant future cancer treatment. In this review, we summarize advances in based on systematic searches PubMed, Embase, Web Science, Scopus databases until 30 September 2022. We highlight targeted delivery explore uses diagnostics, drug delivery, intrinsic anti-cancer agents.

Язык: Английский

Процитировано

47

Bridging Smart Nanosystems with Clinically Relevant Models and Advanced Imaging for Precision Drug Delivery DOI Creative Commons

Qiaoxia Zhou,

Qiongliang Liu,

Yan Wang

и другие.

Advanced Science, Год журнала: 2024, Номер 11(14)

Опубликована: Янв. 28, 2024

Abstract Intracellular delivery of nano‐drug‐carriers (NDC) to specific cells, diseased regions, or solid tumors has entered the era precision medicine that requires systematic knowledge nano‐biological interactions from multidisciplinary perspectives. To this end, review first provides an overview membrane‐disruption methods such as electroporation, sonoporation, photoporation, microfluidic delivery, and microinjection with merits high‐throughput enhanced efficiency for in vitro NDC delivery. The impact characteristics including particle size, shape, charge, hydrophobicity, elasticity on cellular uptake are elaborated several types systems aiming hierarchical targeting vivo reviewed. Emerging ex human/animal‐derived pathophysiological models further explored highly recommended use studies since they might mimic features fill translational gaps animals humans. exploration modern microscopy techniques precise nanoparticle (NP) tracking at cellular, organ, organismal levels informs tailored development NDCs application clinical translation. Overall, integrates latest insights into smart nanosystem engineering, physiological models, imaging‐based validation tools, all directed towards enhancing efficient intracellular NDCs.

Язык: Английский

Процитировано

16

Peptide-Hitchhiking for the Development of Nanosystems in Glioblastoma DOI Creative Commons
Francisco Branco, Joana Cunha, Maria Mendes

и другие.

ACS Nano, Год журнала: 2024, Номер 18(26), С. 16359 - 16394

Опубликована: Июнь 11, 2024

Glioblastoma (GBM) remains the epitome of aggressiveness and lethality in spectrum brain tumors, primarily due to blood–brain barrier (BBB) that hinders effective treatment delivery, tumor heterogeneity, presence treatment-resistant stem cells contribute recurrence. Nanoparticles (NPs) have been used overcome these obstacles by attaching targeting ligands enhance therapeutic efficacy. Among ligands, peptides stand out their ease synthesis high selectivity. This article aims review single multiligand strategies critically. In addition, it highlights other integrate effects external stimuli, biomimetic approaches, chemical approaches as nanocatalytic medicine, revealing significant potential treating GBM with peptide-functionalized NPs. Alternative routes parenteral administration, specifically nose-to-brain delivery local within resected cavity, are also discussed. Finally, an overview them discussed provide a perspective on this promising field therapy.

Язык: Английский

Процитировано

15

Peptide-Mediated Nanocarriers for Targeted Drug Delivery: Developments and Strategies DOI Creative Commons
Yubo Wang, Lu Zhang,

Chen Liu

и другие.

Pharmaceutics, Год журнала: 2024, Номер 16(2), С. 240 - 240

Опубликована: Фев. 6, 2024

Effective drug delivery is essential for cancer treatment. Drug systems, which can be tailored to targeted transport and integrated tumor therapy, are vital in improving the efficiency of Peptides play a significant role various biological physiological functions offer high design flexibility, excellent biocompatibility, adjustable morphology, biodegradability, making them promising candidates delivery. This paper reviews peptide-mediated focusing on self-assembled peptides peptide–drug conjugates. It discusses mechanisms structural control peptides, varieties roles conjugates, strategies augment peptide stability. The review concludes by addressing challenges future directions.

Язык: Английский

Процитировано

11