Roles of long non‑coding RNAs in esophageal cell squamous carcinoma (Review)

International Journal of Molecular Medicine, Год журнала: 2024, Номер 54(2)

Опубликована: Июль 2, 2024

Esophageal squamous cell carcinoma (ESCC) is a prevalent and deadly malignancy of the digestive tract. Recent research has identified long non‑coding RNAs (lncRNAs) as crucial regulators in pathogenesis ESCC. These lncRNAs, typically exceeding 200 nucleotides, modulate gene expression through various mechanisms, including competing endogenous RNA (ceRNA) pathway RNA‑protein interactions. The current study reviews multifaceted roles lncRNAs ESCC, highlighting their involvement processes such proliferation, migration, invasion, epithelial‑mesenchymal transition, cycle progression, resistance to radiotherapy chemotherapy, glycolysis, apoptosis, angiogenesis, autophagy, tumor growth, metastasis maintenance cancer stem cells. Specific like HLA complex P5, LINC00963 repressor NFAT have been shown enhance radio‑ chemotherapy by modulating pathways AKT signaling microRNA interaction, which promote survival proliferation under therapeutic stress. Furthermore, family with sequence similarity 83, member A antisense 1, zinc finger NFX1‑type containing 1 taurine upregulated are implicated enhancing invasive proliferative capabilities ESCC cells ceRNA mechanism, while interactions RNA‑binding proteins further influence behavior. comprehensive analysis underscores potential biomarkers for prognosis targets suggesting avenues future focused on elucidating detailed molecular mechanisms clinical applications management.

Язык: Английский

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The pathogenic germline ETV4 P433L mutation identified in multiple primary lung cancer affect tumor stem-like property by Wnt/β-catenin pathway

Cell Death and Disease, Год журнала: 2024, Номер 15(10)

Опубликована: Окт. 10, 2024

The occurrence of multiple primary lung cancer (MPLC) has witnessed a significant surge in recent years within the Chinese population. MPLC is distinguished by its potential genetic susceptibility and notable heterogeneity. Investigating etiology holds substantial clinical importance.The whole genome sequencing (WGS) genome-wide linkage analysis were performed family affected dominant form abnormalities. Specifically, five members diagnosed with MPLC, while nine had pulmonary nodules one normal member. To confirm pathogenic germline mutations sites, Sanger was an additional 162 patients. Furthermore, molecular biology experiments conducted to investigate function mechanism identified mutation site A549 H322, both vitro vivo. Linkage revealed presence shared genomic regions among members. Subsequent exome deleterious variant these intervals, specifically heterozygous ETS-oncogene transcription factors 4 (ETV4). This particular found at rate 13 out 15 individuals. ETV4 P433L could be detected patients frequency 3.7% (6 162). introduced into cell lines, resulting altered migration stem-like properties cells. Further investigation that activation Wnt/β-catenin signaling pathway, which associated stemness, attributed mutation, suggesting involvement tumor promotion. A novel P433L, family, impact tumors through pathway.

Язык: Английский

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SNHG6 facilitates the epithelial-mesenchymal transition and metastatic potential of esophageal squamous carcinoma through miR-26b-5p/ ITGB1 axis

Scientific Reports, Год журнала: 2024, Номер 14(1)

Опубликована: Окт. 23, 2024

Long non-coding RNAs (lncRNAs), such as SNHG6, have been identified crucial regulators in the progression of various cancers, including esophageal squamous cell carcinoma (ESCC). Although role SNHG6 ESCC is not completely understood, our findings demonstrated that expression upregulated tissues compared to adjacent normal tissues. Furthermore, elevated levels are significantly correlated with higher TNM stage and poorer clinical prognosis patients. Functionally, both vivo vitro experiments shown knocking down inhibits proliferation, invasion, metastasis. Luciferase reporter assays Ago2-RIP assay confirm functions a competing endogenous RNA (ceRNA) by sponging miR-26b-5p modulate ITGB1 ESCC. Given instrumental EMT metastasis, we assessed EMT-related proteins. The suggest reduced can reverse induced lncRNA SHNG6, through rescue analysis. Overall, this study aims elucidate molecular mechanisms which promotes metastasis ESCC, providing novel theoretical foundation for understanding identifying new targets improving outcomes metastatic

Язык: Английский

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Slc25a21 in cisplatin-induced acute kidney injury: a new target for renal tubular epithelial protection by regulating mitochondrial metabolic homeostasis

Cell Death and Disease, Год журнала: 2024, Номер 15(12)

Опубликована: Дек. 18, 2024

Abstract Acute kidney injury (AKI) is a significant global health issue, which often caused by cisplatin therapy and characterized mitochondrial dysfunction. Restoring homeostasis in tubular cells could exert therapeutic effects. Here, we investigated Slc25a21, carrier, as potential target for AKI intervention. Renal Slc25a21 expression negatively associated with function both patients cisplatin-induced murine models. Sustaining renal of slowed down progression reducing cellular apoptosis, necroptosis, the inflammatory response, likely through its regulation 2-oxoadipate conversion. highly expressed proximal epithelial cells, down-regulation contributes to compromised biogenesis integrity, well impaired oxidative phosphorylation. Mechanistically, reduced disrupts transport, affecting related metabolites influx tricarboxylic acid cycle. These findings demonstrate previously unappreciated metabolic suggest that targeting sustaining be novel strategy AKI.

Язык: Английский

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