SLEEP, Год журнала: 2024, Номер 47(5)
Опубликована: Март 18, 2024
Язык: Английский
Alzheimer s & Dementia Diagnosis Assessment & Disease Monitoring, Год журнала: 2024, Номер 16(1)
Опубликована: Янв. 1, 2024
Язык: Английский
Процитировано
6
BMC Public Health, Год журнала: 2025, Номер 25(1)
Опубликована: Фев. 7, 2025
Sleep is a crucial lifestyle factor with impacts on mental and cognitive health. The associations between objectively measured sleep risk of incident dementia are not yet fully understood. To evaluate the device-measured duration regularity explore whether moderates association dementia. Population-based prospective cohort study 82,391 adults aged 43 to 79 years from UK Biobank accelerometry subsample, collected 2013 2015, followed up 2022. Device-based (h/day) index (SRI), metric ranging 0-100 that quantifies person's (with greater value indicating higher consistency), were calculated wrist-worn data recorded over course one week. Incident all-cause cases obtained national hospital admission, primary care mortality 30 November We used Cox proportional hazard models estimate ratios (HRs) for after adjustment common demographic clinical covariates. Over mean follow-up 7.9 years, 694 occurred. observed U-shaped dementia, only short (< 7 h) being significantly associated median sleepers 6.5 h, compared reference point h was HR 1.19 (95%CI 1.01,1.40) negatively in near-linear fashion (linear p = 0.01, non-linear 0.57). When we dichotomized regularity, those group (SRI ≥ 70) had an 0.74 0.63, 0.87) lower < 70). beneficial present among participants long (≥ 8 duration. Assuming causal, maintaining regular pattern may help offset deleterious inadequate Interventions aimed at improving be viable option people able achieve recommended hours sleep.
Язык: Английский
Процитировано
0
The Journal of Prevention of Alzheimer s Disease, Год журнала: 2025, Номер unknown, С. 100130 - 100130
Опубликована: Март 1, 2025
Alzheimer's disease (AD) is a neurodegenerative disorder characterised by amyloid-β (Aβ), tau hyperphosphorylation and neurodegeneration. Blood-based biomarkers are emerging as minimally invasive tool for detection monitoring. This review depicts the relationships between modifiable lifestyle factors (nutrition, physical activity (PA), sleep, alcohol consumption, smoking, social isolation) plasma of AD: Aβ42, Aβ40, Aβ42/40, phosphorylated tau, total neurofilament light chain (NfL) glial fibrillary acidic protein. Limited evidence suggests that better nutrition associated with favourable AD biomarker profiles PA less NfL Aβ, whilst poor sleep elevated Aβ. However, lack data inconsistent findings highlight need further investigation to substantiate or refute these trends. Moreover, future research should include analysis on according gender, metabolic health APOE status. Considering growing emphasis preventing delaying dementia onset justified.
Язык: Английский
Процитировано
0
Alzheimer s Research & Therapy, Год журнала: 2025, Номер 17(1)
Опубликована: Апрель 5, 2025
Disruptions in circadian rhythms are commonly observed patients with Alzheimer's disease (AD) and could potentially accelerate the progression of condition. However, relationship between rhythm disruptions AD development, as well mechanisms involved, remain poorly understood. This study investigated behavior, rhythmic gene expression multiple brain regions, its correlation sleep architecture mice at two stages: plaque-free stage (2-month-old) plaque-burdened (10-month-old) compared to age-matched wild-type (WT) mice. Two-month-old already displayed alteration activity patterns WT mice, showing increased during light phase decreased dark phase, change pattern 10-month-old was more significant. Further, electroencephalogram (EEG) examination showed wakefulness reduced non-rapid eye movement (NREM) 2- In addition, we documented a significant core clock genes suprachiasmatic nucleus (SCN), hippocampus, cortex Correlation analyses demonstrated close level specific sleep-wake parameters, especially within SCN hippocampus. These findings revealed that disturbances preceded Aβ deposition. The early might be attributed abnormal regions involved regulation.
Язык: Английский
Процитировано
0
Neuroscience, Год журнала: 2025, Номер unknown
Опубликована: Апрель 1, 2025
Язык: Английский
Процитировано
0
SLEEP, Год журнала: 2024, Номер 47(5)
Опубликована: Март 18, 2024
Язык: Английский
Процитировано
2