Cancer Metabolism: The Role of ROS in DNA Damage and Induction of Apoptosis in Cancer Cells

Metabolites, Год журнала: 2023, Номер 13(7), С. 796 - 796

Опубликована: Июнь 27, 2023

Cancer is a huge challenge for people worldwide. High reactive oxygen species (ROS) levels are recognized hallmark of cancer and an important aspect treatment research. Abnormally elevated ROS often attributable to alterations in cellular metabolic activities increased oxidative stress, which affects both the development maintenance cancer. Moderately high beneficial maintain tumor cell genesis development, while toxic have been shown be force destroying cells. has become anticancer target based on proapoptotic effect ROS. Therefore, this review summarizes role DNA damage apoptosis cells caused by changes metabolism, as well various therapies targeting generation, order provide references generation.

Язык: Английский

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Novel Strategies for Tumor Treatment: Harnessing ROS-Inducing Active Ingredients from Traditional Chinese Medicine Through Multifunctional Nanoformulations

International Journal of Nanomedicine, Год журнала: 2024, Номер Volume 19, С. 9659 - 9688

Опубликована: Сен. 1, 2024

Reactive oxygen species (ROS) encompass a diverse group of chemically reactive molecules or ions distinguished by their substantial oxidative potential. Empirical studies have shown that the targeted administration high toxic concentrations ROS can effectively induce tumor cell death in various types. Numerous bioactive ingredients derived from traditional Chinese medicine (TCM), recognized for ROS-inducing properties, demonstrated significant anti-tumor activity. Nonetheless, clinical application has been hindered challenges such as low solubility, limited bioavailability, and poor selectivity. Multifunctional nanoformulations possess potential to overcome these enhance anticancer efficacy active compounds. Through extensive searches academic databases thorough review screening relevant literature, this study aims systematically summarize generalize multiple TCM generation, along with multifunctional nanoformulations, perspectives. The objective is provide new insights references fundamental cancer research treatments. Furthermore, we acknowledge although numerous potentials, potentially offering novel strategies therapy, underlying mechanisms require further comprehensive investigation.

Язык: Английский

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Natural products target programmed cell death signaling mechanisms to treat colorectal cancer

Frontiers in Pharmacology, Год журнала: 2025, Номер 16

Опубликована: Апрель 24, 2025

As a highly prevalent gastrointestinal malignant tumor, colorectal cancer poses serious challenge in terms of increasing morbidity and mortality late diagnosis due to the invisibility disease. Although existing therapies are diverse but limited efficacy, mechanism programmed cell death (PCD) has become focus research its central role maintaining body homeostasis regulating tumor progression. Multimodal pathways, such as apoptosis, autophagy, pyroptosis ferroptosis, have shown unique advantages inhibiting proliferation migration cells enhancing sensitivity chemotherapy by responding internal external environmental stimuli. In recent years, natural products risen prominence virtue their multi-target synergistic effects chemo-sensitizing properties, opened up new direction for treatment precisely PCD pathway. this paper, we searched PubMed, Web Science CNKI databases relevant studies last 10 years using keywords (Colorectal cancer) (programmed death) products. This work retrieved 59 (55 from past 5 4 years) reveal action targeting PCD, aiming provide theoretical support practical guidance optimization clinical therapeutic strategies development innovative drugs.

Язык: Английский

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Modulating Endoplasmic Reticulum Stress in Gastrointestinal Cancers: Insights from Traditional Chinese Medicine

Pharmaceuticals, Год журнала: 2024, Номер 17(12), С. 1599 - 1599

Опубликована: Ноя. 27, 2024

Endoplasmic reticulum (ER) stress and the unfolded protein response (UPR) play critical roles in tumorigenesis, cancer progression, drug resistance. Persistent activation of ER system enhances survival capacities malignant tumor cells, including increased proliferation, invasion, resistance to treatment. Dysregulation function resultant is a common cellular therapies may lead cell death. Currently, growing evidence suggests that Traditional Chinese medicine (TCM), either as monotherapy or combination with other treatments, offers significant advantages preventing cancer, inhibiting growth, reducing surgical complications, improving sensitivity, mitigating drug-induced damage. Some these natural products have even entered clinical trials primary complementary anticancer agents. In this review, we summarize effects TCM monomers/natural on gastrointestinal (GI) tumors explore their mechanisms through modulation. We believe ongoing laboratory research development TCM-based hold considerable potential for advancing future treatments.

Язык: Английский

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The Biological Assessment of Shikonin and β,β-dimethylacrylshikonin Using a Cellular Myxofibrosarcoma Tumor Heterogeneity Model

International Journal of Molecular Sciences, Год журнала: 2023, Номер 24(21), С. 15910 - 15910

Опубликована: Ноя. 2, 2023

Myxofibrosarcoma (MFS) is a subtype of soft tissue sarcoma connective tissue, which characterized by large intra-tumor heterogeneity. Therapy includes surgical resection. Additional chemotherapy limited effect. In this study, we demonstrated the potent anticancer activity shikonin derivatives in our MFS cellular model tumor heterogeneity for developing new therapeutic approach. The impact and β,β-dimethylacrylshikonin (DMAS) on viability, apoptotic induction, MAPK phosphorylation, DNA damage response were analyzed means two human cell lines, MUG-Myx2a MUG-Myx2b, derived from singular specimen. cells showed dose-dependent inhibition viability significant induction apoptosis. Treatment with caused an pSTAT3 increase pAKT, pERK, pJNK, pp38. DMAS inhibited activation master upstream regulators response, ATR ATM. contains additional PTEN mutation, was more sensitive some targets. These data demonstrate antitumorigenic effect highlight importance treatment planning.

Язык: Английский

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Enhancing extraction of shikonin and phenolic antioxidants from Echium italicum L. using ultrasound and response surface methodology: optimizing temperature, time, and liquid–solid ratio

Biomass Conversion and Biorefinery, Год журнала: 2024, Номер unknown

Опубликована: Окт. 7, 2024

Язык: Английский

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Research progress on the structural and anti-colorectal malignant tumor properties of Shikonin

Journal of Cancer Research and Therapeutics, Год журнала: 2024, Номер 20(7), С. 1957 - 1963

Опубликована: Дек. 1, 2024

Язык: Английский

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