Small Molecules Targeting Non-Coding RNAs Regulating Ferroptosis: New Opportunities in Precision Cancer Therapy DOI
Junjing Zhang, Yan Wang, Joshua S. Fleishman

и другие.

Antioxidants and Redox Signaling, Год журнала: 2025, Номер unknown

Опубликована: Май 23, 2025

Ferroptosis, a distinct form of regulated cell death (RCD), has emerged as promising approach for cancer treatment owing to its potential inhibit tumor malignancy. Research indicates that non-coding RNAs (ncRNAs) regulate ferroptosis susceptibility in cells through epigenetic modifications. ncRNAs play essential roles initiation, metastasis, and drug resistance. Findings indicate small-molecule compounds (SMCs) target ferroptosis, providing new opportunities precision therapy. Therefore, this review aims elucidate current molecular mechanisms underlying ncRNA-mediated regulation investigate the SMCs therapeutic agents modulate process, offering strategy treatment. This also summarizes innovative targeting with SMCs, regulating transforming landscape Overall, it highlights novel therapy by pharmacologically ncRNA-ferroptosis axis SMCs. Antioxid. Redox Signal. 00, 000-000.

Язык: Английский

Unraveling the role of the P2X7 receptor in cancer radioresistance: Molecular insights and therapeutic implications DOI

Seyedeh Nasibeh Mousavikia,

Maryam Moghaddam Matin,

Mohammad Taghi Bahreyni Tossi

и другие.

Biochimica et Biophysica Acta (BBA) - Molecular Cell Research, Год журнала: 2025, Номер 1872(3), С. 119910 - 119910

Опубликована: Янв. 29, 2025

Язык: Английский

Процитировано

0
Small Molecules Targeting Non-Coding RNAs Regulating Ferroptosis: New Opportunities in Precision Cancer Therapy DOI
Junjing Zhang, Yan Wang, Joshua S. Fleishman

и другие.

Antioxidants and Redox Signaling, Год журнала: 2025, Номер unknown

Опубликована: Май 23, 2025

Ferroptosis, a distinct form of regulated cell death (RCD), has emerged as promising approach for cancer treatment owing to its potential inhibit tumor malignancy. Research indicates that non-coding RNAs (ncRNAs) regulate ferroptosis susceptibility in cells through epigenetic modifications. ncRNAs play essential roles initiation, metastasis, and drug resistance. Findings indicate small-molecule compounds (SMCs) target ferroptosis, providing new opportunities precision therapy. Therefore, this review aims elucidate current molecular mechanisms underlying ncRNA-mediated regulation investigate the SMCs therapeutic agents modulate process, offering strategy treatment. This also summarizes innovative targeting with SMCs, regulating transforming landscape Overall, it highlights novel therapy by pharmacologically ncRNA-ferroptosis axis SMCs. Antioxid. Redox Signal. 00, 000-000.

Язык: Английский

Процитировано

0