Sex-Specific Differences and the Role of Environmental Enrichment in the Expression of Hippocampal CB1 Receptors following Chronic Unpredictable Stress DOI Creative Commons
Εvgenia Dandi, Evangelia Kesidou, Constantina Simeonidou

и другие.

Brain Sciences, Год журнала: 2024, Номер 14(4), С. 357 - 357

Опубликована: Апрель 3, 2024

Stress-related mental disorders have become increasingly prevalent, thus endangering health worldwide. Exploring stress-associated brain alterations is vital for understanding the possible neurobiological mechanisms underlying these changes. Based on existing evidence, endogenous cannabinoid system (ECS) plays a significant role in stress response, and disruptions its function are associated with neurobiology of various stress-related disorders. This study primarily focuses investigating impact chronic unpredictable (CUS) expression hippocampal type 1 (CB1) receptors, part ECS, adult male female Wistar rats. Additionally, it explores whether environmental enrichment (EE) initiated during adolescence could mitigate CUS-associated CB1 expression. rats, shortly after weaning, were placed either standard housing (SH) or EE conditions duration 10 weeks. On postnatal day 66, specific subgroups SH animals underwent 4-week CUS protocol. Western blot (WB) analysis was conducted whole hippocampus left hemisphere to assess total protein expression, while immunohistochemistry (IHC) performed right estimate receptors certain areas (i.e., CA1, CA3 dentate gyrus-DG). The WB revealed no statistically differences levels among groups; however, reduced found sub-regions using IHC. Specifically, significantly decreased receptor CA1 DG both sexes, whereas decrease limited males. Interestingly, proved protective against reductions. These findings suggest region sex-specific endocannabinoid response stress, emphasizing positive early experiences protection adolescent adverse later life.

Язык: Английский

The connecting brain in context: How adolescent plasticity supports experiential learning and development DOI Creative Commons
Amanda E. Baker, Adriana Galván, Andrew J. Fuligni

и другие.

Developmental Cognitive Neuroscience, Год журнала: 2024, Номер 71, С. 101486 - 101486

Опубликована: Ноя. 28, 2024

Язык: Английский

Процитировано

3
Sex-Specific Differences and the Role of Environmental Enrichment in the Expression of Hippocampal CB1 Receptors following Chronic Unpredictable Stress DOI Creative Commons
Εvgenia Dandi, Evangelia Kesidou, Constantina Simeonidou

и другие.

Brain Sciences, Год журнала: 2024, Номер 14(4), С. 357 - 357

Опубликована: Апрель 3, 2024

Stress-related mental disorders have become increasingly prevalent, thus endangering health worldwide. Exploring stress-associated brain alterations is vital for understanding the possible neurobiological mechanisms underlying these changes. Based on existing evidence, endogenous cannabinoid system (ECS) plays a significant role in stress response, and disruptions its function are associated with neurobiology of various stress-related disorders. This study primarily focuses investigating impact chronic unpredictable (CUS) expression hippocampal type 1 (CB1) receptors, part ECS, adult male female Wistar rats. Additionally, it explores whether environmental enrichment (EE) initiated during adolescence could mitigate CUS-associated CB1 expression. rats, shortly after weaning, were placed either standard housing (SH) or EE conditions duration 10 weeks. On postnatal day 66, specific subgroups SH animals underwent 4-week CUS protocol. Western blot (WB) analysis was conducted whole hippocampus left hemisphere to assess total protein expression, while immunohistochemistry (IHC) performed right estimate receptors certain areas (i.e., CA1, CA3 dentate gyrus-DG). The WB revealed no statistically differences levels among groups; however, reduced found sub-regions using IHC. Specifically, significantly decreased receptor CA1 DG both sexes, whereas decrease limited males. Interestingly, proved protective against reductions. These findings suggest region sex-specific endocannabinoid response stress, emphasizing positive early experiences protection adolescent adverse later life.

Язык: Английский

Процитировано

2