International Journal of Biological Macromolecules, Год журнала: 2024, Номер 265, С. 131097 - 131097
Опубликована: Март 26, 2024
Язык: Английский
Diabetes/Metabolism Research and Reviews, Год журнала: 2021, Номер 38(2)
Опубликована: Сен. 13, 2021
Diabetes mellitus (DM), a chronic metabolic disease characterised by elevated levels of blood glucose, is among the most common diseases. The incidence and prevalence DM have been increasing over years. complications represent serious health problem. long-term include macroangiopathy, microangiopathy neuropathy as well sexual dysfunction (SD) in both men women. Erectile (ED) has considered important SD with DM. ED approximately 3.5-fold higher than those without Common risk factors for development its sedentary lifestyle, overweight/obesity increased caloric consumption. Although lifestyle changes may help improve function, specific treatments are often needed. This study aims to review definition DM, impact treatment on and, finally, current emerging therapies patients
Язык: Английский
Процитировано
170
Molecular Medicine, Год журнала: 2024, Номер 30(1)
Опубликована: Янв. 15, 2024
Abstract Male infertility is a physiological phenomenon in which man unable to impregnate fertile woman during 12-month period of continuous, unprotected sexual intercourse. A growing body clinical and epidemiological evidence indicates that the increasing incidence male reproductive problems, especially infertility, shows very similar trend diabetes within same age range. In addition, large number previous vivo vitro experiments have also suggested complex pathophysiological changes caused by may induce multiple aspects, including hypothalamic-pituitary–gonadal axis dysfunction, spermatogenesis maturation disorders, testicular interstitial cell damage erectile dysfunction. Based on above related mechanisms, studies focused potential therapeutic association between progression patients with providing important clues for treatment this population. paper, we summarized research results effects function recent 5 years, elaborated mechanisms induced diabetes, reviewed prospected measures.
Язык: Английский
Процитировано
33
Periodontology 2000, Год журнала: 2024, Номер 94(1), С. 257 - 414
Опубликована: Фев. 1, 2024
Abstract Exosomes are the smallest subset of extracellular signaling vesicles secreted by most cells with ability to communicate other tissues and cell types over long distances. Their use in regenerative medicine has gained tremendous momentum recently due their be utilized as therapeutic options for a wide array diseases/conditions. Over 5000 publications currently being published yearly on this topic, number is only expected dramatically increase novel strategies continue developed. Today exosomes have been applied numerous contexts including neurodegenerative disorders (Alzheimer's disease, central nervous system, depression, multiple sclerosis, Parkinson's post‐traumatic stress disorders, traumatic brain injury, peripheral nerve injury), damaged organs (heart, kidney, liver, stroke, myocardial infarctions, ovaries), degenerative processes (atherosclerosis, diabetes, hematology musculoskeletal degeneration, osteoradionecrosis, respiratory disease), infectious diseases (COVID‐19, hepatitis), procedures (antiaging, bone regeneration, cartilage/joint osteoarthritis, cutaneous wounds, dental dermatology/skin erectile dysfunction, hair regrowth, intervertebral disc repair, spinal cord vascular regeneration), cancer therapy (breast, colorectal, gastric osteosarcomas), immune function (allergy, autoimmune regulation, inflammatory diseases, lupus, rheumatoid arthritis). This scoping review first its kind aimed at summarizing extensive potential broad range disorders.
Язык: Английский
Процитировано
22
Frontiers in Endocrinology, Год журнала: 2024, Номер 15
Опубликована: Апрель 4, 2024
Background Previous studies have established that diabetes mellitus (DM) markedly raises the risk of developing erectile dysfunction (ED). Despite extensive investigations, factors associated with ED in diabetic men yet to be unequivocally determined, owing incongruent and inconclusive results reported various studies. Objective The objective this systematic review meta-analysis was assess for DM. Methods A comprehensive conducted, encompassing published PubMed, Scopus Embase databases up August 24th, 2023. All examining patients DM were included analysis. To identify significant variations among factors, odds ratios (ORs) their corresponding 95% confidence intervals (CIs) employed. bias evaluated using Newcastle-Ottawa Scale(NOS) longitudinal Agency Healthcare Research Quality Scale(AHRQ) cross-sectional Results total 58 studies, including a substantial participant pool 66,925 individuals diagnosed DM, both or without ED, meta-analysis. Mean age (OR: 1.31, CI=1.24-1.37), smoking status 1.32, CI=1.18-1.47), HbA1C 1.44, CI=1.28-1.62), duration 1.39, CI=1.29-1.50), neuropathy 3.47, CI=2.16-5.56), retinopathy 3.01, CI=2.02-4.48), foot 3.96, CI=2.87-5.47), cardiovascular disease 1.92, CI=1.71-2.16), hypertension 1.74, CI=1.52-2.00), microvascular 2.14, CI=1.61-2.85), vascular 2.75, CI=2.35-3.21), nephropathy 2.67, CI=2.06-3.46), depression 1.82, CI=1.04-3.20), metabolic syndrome 2.22, CI=1.98-2.49), diuretic treatment 2.42, CI=1.38-4.22) increased Conclusion Our study indicates several been identified, mean age, HbA1C, neuropathy, retinopathy, foot, disease, hypertension, nephropathy, depression, syndrome, treatment. By clarifying connection between these clinicians scientific experts can intervene address ultimately reducing occurrence improving patient management.
Язык: Английский
Процитировано
20
CARDIOVASCULAR THERAPY AND PREVENTION, Год журнала: 2024, Номер 23(3), С. 3696 - 3696
Опубликована: Апрель 1, 2024
Создание руководства поддержано Советом по терапевтическим наукам отделения клинической медицины Российской академии наук.
Язык: Русский
Процитировано
19
International Journal of Nanomedicine, Год журнала: 2022, Номер Volume 17, С. 1229 - 1253
Опубликована: Март 1, 2022
Abstract: Diabetes mellitus (DM) is among the chronic metabolic disorders that its incidence rate has shown an increase in developed and wealthy countries due to lifestyle obesity. The treatment of DM always been interest, significant effort made this field. Exosomes belong extracellular vesicles with nanosized features (30– 150 nm) are involved cell-to-cell communication preserving homeostasis. function exosomes different based on their cargo, they may contain lipids, proteins, nucleic acids. present review focuses application DM; both glucose lipid levels significantly affected by exosomes, these nanostructures enhance metabolism decrease deposition. Furthermore, promote affect level glycolytic enzymes transporters DM. Type I results from destruction β cells pancreas, can be employed ameliorate apoptosis endoplasmic reticulum (ER) stress cells. have dual functions mediating insulin resistance/sensitivity, M1 macrophage-derived inhibit secretion. miRNAs, transferring cells, regulate various molecular pathways such as AMPK, PI3K/Akt, β-catenin progression. Noteworthy, body fluids blood circulation, biomarkers for diagnosis diabetic patients. Future studies should focus engineering derived sources mesenchymal stem treat a novel strategy. Keywords: diabetes mellitus, resistance, exosome, uptake, Corrigendum paper published
Язык: Английский
Процитировано
63
Journal of Endocrinological Investigation, Год журнала: 2022, Номер 46(1), С. 15 - 26
Опубликована: Авг. 9, 2022
Abstract Purpose We herein aimed to review the new insights into impact of impaired thyroid function on male and female fertility, spacing from spontaneous pregnancy ART, with objective providing an updated narrative revision literature. Methods This was performed for all available prospective, retrospective articles, published up 2021 in PubMed. Data were extracted text tables manuscript. Results Thyroid dysfunction is frequently associated infertility, whereas its link infertility debated. Female wise, detrimental obstetric fetal outcomes both pregnancies those achieved thanks assisted reproduction technologies (ART). Furthermore, reference range TSH natural ART procedures has recently become a matter debate following recent reports this field. On other hand, reproductive system less clear, although possible role suggested via modulation Sertoli Leydig cells spermatogenesis. Conclusion should be carefully monitored female, couples seeking as well treatment generally immediate likely improve chances success.
Язык: Английский
Процитировано
44
Diabetes & Metabolic Syndrome Clinical Research & Reviews, Год журнала: 2024, Номер 18(5), С. 103044 - 103044
Опубликована: Май 1, 2024
Smoking in people with diabetes markedly elevates their risk of developing complications and increases the likelihood cardiovascular mortality. This review is first to specifically provide evidence-based analysis about influence quitting smoking on diabetes-related type 2 diabetes.
Язык: Английский
Процитировано
11
Andrology, Год журнала: 2022, Номер 11(2), С. 257 - 269
Опубликована: Авг. 5, 2022
Erectile dysfunction is associated with diabetes mellitus an estimated prevalence of 52.5% in the diabetic population. The first-line therapy for erectile phosphodiesterase type 5 inhibitors, but data suggest that men may be less responsive than non-diabetic men. Thus, other treatments, including intracavernosal injections, intraurethral prostaglandin, vacuum erection devices and penile prosthetic surgery, should considered management refractory to inhibitors. Furthermore, combination inhibitors oral treatments such as arginine or l-carnitine have synergistic effects resulting better outcomes. In addition, there are novel therapies low-intensity shockwave stem-cell therapy, which also effective targeted treatment modalities. studies can improved by targeting concurrent comorbidities metabolic diseases depression, hypertension, hypogonadism, dyslipidaemia. We present evidence-based narrative review focusing on who not responded inhibitors.Both clinicians patients aware different options
Язык: Английский
Процитировано
30
Biomedicine & Pharmacotherapy, Год журнала: 2024, Номер 177, С. 116987 - 116987
Опубликована: Июнь 18, 2024
Erectile dysfunction is a complex and common complication of diabetes mellitus, which lacks an effective treatment. The repairing role vascular endothelium the current research hotspot diabetic mellitus erectile (DMED), activation PI3K/AKT/eNOS pathway positively affects repair endothelium. herbal extract isorhamnetin has significant vasoprotective effects great potential in treating DMED. This study aimed to clarify whether ameliorative effect on DMED investigate modulation signaling by discover its mechanism action. In vivo experiments were performed using streptozotocin-induced rat model, efficacy was assessed after 4 weeks gavage administration at 10 mg/kg or 20 mg/kg. function rats maximum intracavernous pressure/mean arterial pressure (ICPmax/MAP), changes corpus cavernosum (CC) fibrosis, inflammation levels, oxidative stress apoptosis molecular biology techniques. vitro high glucose-induced endothelial cells further validate anti-apoptotic regulation pathway. findings demonstrated that enhanced function, decreased collagen content, increased smooth muscle content CC rats. addition, serum levels pro-inflammatory factors IL-6, TNF-α, IL-1β, anti-inflammatory IL-10 IL-4, activities SOD, GPx, CAT as well NO, MDA tissues. Isorhamnetin also CD31 tissues rats, activated pathway, inhibited apoptosis. conclusion, exerts protective reducing inflammatory response, attenuating level improving inhibiting underlying these may be linked
Язык: Английский
Процитировано
9