Pharmacology Options for Bulimia Nervosa DOI
Aaron Keshen,

Susan Gamberg,

Sara Bartel

и другие.

Eating Disorders, Год журнала: 2022, Номер unknown, С. 1 - 22

Опубликована: Янв. 1, 2022

Although psychotherapy is effective for bulimia nervosa (BN), many individuals remain symptomatic after treatment. Therefore, pharmacotherapies have been studied as stand-alone treatments, and adjuncts psychotherapy, with the goal of improving outcomes BN. Despite much research in this area, fluoxetine remains only medication regulatory approval. However, there are off-label options several medications development. The chapter to review literature related following BN: a) antidepressants, b) antiepileptics, c) stimulants, d) other medications. We will also combining pharmacotherapy those BN present evidence treatment youth disorder.

Язык: Английский

Use of glucagon‐like peptide‐1 receptor agonists in eating disorder populations DOI Creative Commons
Sara Bartel, Susan L. McElroy, Danielle Levangie

и другие.

International Journal of Eating Disorders, Год журнала: 2023, Номер 57(2), С. 286 - 293

Опубликована: Дек. 22, 2023

Abstract Glucagon‐like peptide‐1 receptor agonists (GLP‐1As) are being used as approved or off‐label treatments for weight loss. As such, there has been increasing concern about the potential GLP‐1As to impact eating disorder (ED) symptomatology. This article seeks (1) review current state of knowledge regarding and ED symptomatology; (2) provide recommendations future research; (3) guide clinicians in how discuss clinical practice. Although evidence is limited, it possible that could exacerbate, contribute development of, pathology negatively treatment. Preliminary research on use treat binge conducted; however, studies have design limitations additional needed. Therefore, at time not sufficient support GLP‐1s symptoms. In summary, more required before negative positive conclusions can be drawn EDs psychopathology. Herein, we specific a help navigate discussions with their clients GLP‐1As. A client handout also provided. Public Significance Despite glucagon‐like (GLP‐1As; e.g., semaglutide) increasingly topic public discourse, little known It maintain, worsen, improve reviews limited literature symptoms, recommends research, provides discussing clients.

Язык: Английский

Процитировано

35
Classic psychedelics and alcohol use disorders: A systematic review of human and animal studies DOI
Javier Calleja‐Conde, José Á. Morales-García, Víctor Echeverry‐Alzate

и другие.

Addiction Biology, Год журнала: 2022, Номер 27(6)

Опубликована: Авг. 31, 2022

Classic psychedelics refer to substances such as lysergic acid diethylamide (LSD), psilocybin, ayahuasca, and mescaline, which induce altered states of consciousness by acting mainly on 5-HT

Язык: Английский

Процитировано

33
Safety of Stimulants Across Patient Populations DOI Creative Commons
Henrique Nunes Pereira Oliva, Tiago Paiva Prudente,

Talia F. Mayerson

и другие.

JAMA Network Open, Год журнала: 2025, Номер 8(5), С. e259492 - e259492

Опубликована: Май 9, 2025

Importance The use of stimulant medications has expanded substantially beyond the traditional treatment attention-deficit/hyperactivity disorder (ADHD) to encompass a variety other clinical conditions. Understanding safety these is important as their increases across diverse patient populations. Objective To assess reported in randomized trials (RCTs) investigating methylphenidate, lisdexamfetamine, and amphetamines. Data Sources A comprehensive literature search was conducted from July 1, 2024, through February 28, 2025, using CINAHL, Embase, PubMed or MEDLINE, ScienceDirect, Web Science for studies published since 2000. Keywords included safety, adverse event, side effect, amphetamine, dextroamphetamine, stimulant, methylphenidate . Study Selection RCTs between January 2000, December 13, were included. These investigated stimulants various conditions, including ADHD, depression, binge eating disorder, schizophrenia, Alzheimer disease, disorders well healthy individuals. Trials not focused on events (AEs) stimulants, nonoriginal research, nonhuman with concomitant prescriptions than without placebo group excluded. Extraction Synthesis extraction followed Preferred Reporting Items Systematic Reviews Meta-Analyses (PRISMA) reporting guideline. Independent reviewers extracted study data, random-effects model used pool results. Heterogeneity assessed I 2 statistic. Main Outcomes Measures primary outcome risk ratio (RR) developing any AE participants taking vs placebo. Results total 93 after exclusions. methodological quality assessment showed overall low unclear bias. duration up 52 weeks that associated an increased AEs compared (RR, 1.34; 90% CI, 1.27-1.41), high heterogeneity ( = 67%). Statistical significance this finding maintained when subgroups (ie, amphetamines) separately analyzed. Conclusions Relevance This meta-analysis found Future research could provide more standardized consistent assessments may improve understanding about misuse risk.

Язык: Английский

Процитировано

1
Fascia as a regulatory system in health and disease DOI Creative Commons

Alison M. Slater,

S. Jade Barclay,

Rouha M. S. Granfar

и другие.

Frontiers in Neurology, Год журнала: 2024, Номер 15

Опубликована: Авг. 7, 2024

Neurology and connective tissue are intimately interdependent systems critical in regulating many of the body's systems. Unlocking their multifaceted relationship can transform clinical understanding mechanisms involved multisystemic regulation dysregulation. The fascial system is highly innervated rich with blood vessels, lymphatics, hormonal neurotransmitter receptors. Given its ubiquity, fascia may serve as a "watchman," receiving processing information on whole body health. This paper reviews what constitutes fascia, why it clinically important, contiguous nervous system. Unquestionably, integrity paramount to human locomotion, interaction our environment, bodily sense, general physical emotional wellbeing, so an dysregulation that defines range pathological states, including hypermobility syndromes, autonomic dysregulation, mast cell activation, acquired disorders ensuring recognition, research, appropriate management these conditions, satisfaction patient well treating practitioner.

Язык: Английский

Процитировано

5
Metabolic, behavioral health, and disordered eating comorbidities associated with obesity in pediatric patients: An Obesity Medical Association (OMA) Clinical Practice Statement 2022 DOI
Suzanne Cuda, Roohi Y. Kharofa, Dominique R. Williams

и другие.

Obesity Pillars, Год журнала: 2022, Номер 3, С. 100031 - 100031

Опубликована: Авг. 6, 2022

Язык: Английский

Процитировано

15
The roles of impulsivity, comorbid ADHD, and borderline personality disorder in patients with bulimia nervosa DOI Creative Commons

Susanne Gilsbach,

Julia Leuchtenberger,

Beate Herpertz‐Dahlmann

и другие.

Eating and Weight Disorders - Studies on Anorexia Bulimia and Obesity, Год журнала: 2025, Номер 30(1)

Опубликована: Янв. 18, 2025

Bulimia nervosa (BN) is a serious mental illness with impulsivity as cardinal symptom. Impulsivity contributes to various other, often comorbid, disorders, such attention deficit/hyperactivity disorder (ADHD) and borderline personality (BPD). The aim of this study was explore comorbidities BN ADHD BPD well the contribution an underlying trait linking these disorders. Hundred fifteen females 98 healthy matched controls (HC) (age range between 16 48 years) were assessed regarding adult childhood-ADHD, disorders impulsivity. Patients more impulsive (p < 0.001) fulfilled criteria childhood/adulthood than HC, expected in general population. Childhood-ADHD = 0.009) 0.017) both significant positive predictors for scores found patients BN. Comorbidity prevalent associated increase impulsivity, latter being relevant transdiagnostic trait. It might be beneficial clinical care Evidence obtained from well-designed cohort or case-control analytic studies.

Язык: Английский

Процитировано

0
Repurposed Drugs of Abuse (Stimulants, Ketamine, and Psychedelics): Focus on Risks DOI
Breno Souza‐Marques, Ana Teresa Caliman‐Fontes, Gustavo C. Leal

и другие.

Опубликована: Янв. 1, 2025

Язык: Английский

Процитировано

0
Microextraction Techniques for Sample Preparation of Amphetamines in Urine: A Comprehensive Review DOI

Nasim Nourani,

Arezou Taghvimi,

Ahad Bavili-Tabrizi

и другие.

Critical Reviews in Analytical Chemistry, Год журнала: 2022, Номер unknown, С. 1 - 16

Опубликована: Сен. 11, 2022

Psychological disorders and dramatic social problems are serious concerns regarding the abuse of amphetamine its stimulant derivatives worldwide. Consumers such drugs experience great euphoria along with health problems. Determination quantification amphetamine-type stimulants indispensable skills for clinical forensic laboratories. Analysis low drug doses in bio-matrices necessitates applications simple also effective preparation steps. The procedures not only eliminate adverse matrix effects, but provide reasonable clean-up pre-concentration benefits. current review presents different methods used sample amphetamines from urine as most frequently biological matrix. advantages limitations various were discussed focusing on miniaturized methods.

Язык: Английский

Процитировано

11
Accessibility of Psychological Treatments for Bulimia Nervosa: A Review of Efficacy and Engagement in Online Self-Help Treatments DOI Open Access
Sarah Barakat, Sarah Maguire

International Journal of Environmental Research and Public Health, Год журнала: 2022, Номер 20(1), С. 119 - 119

Опубликована: Дек. 22, 2022

Bulimia nervosa is an eating disorder characterised by marked impairment to one’s physical health and social functioning, as well high rates of chronicity comorbidity. This literature review aims summarise existing academic research related the symptom profile BN, costs burden imposed illness, barriers receipt care, evidence base for available psychological treatments. As a consequence well-documented difficulties in accessing evidence-based treatments disorders, efforts have been made towards developing innovative, diverse channels deliver treatment, with several these attempting harness potential digital platforms. In response increasing number trials investigating utility online treatments, this paper provides critical previous attempts examine interventions treatment disorders. The results focused are presented, including detailed synthesis knowledgeable selection high-quality articles aim providing update on current state field. highlight self-help produce moderately sized reductions core behavioural cognitive symptoms However, concern raised regarding methodological limitations field, dropout poor adherence reported across most studies. suggests directions future research, need replicate findings using rigorous study design methodology, further investigation clinician support interactive features mechanisms offsetting low engagement

Язык: Английский

Процитировано

11
Practice Pearls for Stimulant Treatment of Attention-Deficit/Hyperactivity Disorder in Youth. DOI
Danielle L. Stutzman, Julie A. Dopheide

PubMed, Год журнала: 2024, Номер 29(3), С. 215 - 231

Опубликована: Июнь 1, 2024

Over half of youth with attention-deficit/hyperactivity disorder (ADHD) have co-occurring psychiatric or medical conditions that present treatment challenges. Stimulants are the most effective pharmacologic ADHD for preschoolers to adults but questions about safety frequently arise. In addition, stigma surrounding diagnosis and can negatively impact care. This manuscript presents evidence-based practice pearls guide decisions common coexisting conditions. Recommendations address specific stimulant adverse effects (i.e., anxiety, cardiac, growth, mania, psychosis) along management strategies. Pearls were developed clinical questions, controversial topics, therapeutic issues may not be widely known. The goals this to: 1) provide a detailed resource interprofessional teams regarding use in ADHD, 2) improve outcomes and/or through recommendations, 3) decrease associated education.

Язык: Английский

Процитировано

2