Multiple Sclerosis Journal, Год журнала: 2023, Номер 29(10), С. 1204 - 1205
Опубликована: Сен. 1, 2023
Язык: Английский
Neurology and Therapy, Год журнала: 2024, Номер unknown
Опубликована: Сен. 4, 2024
Язык: Английский
Процитировано
1
Multiple Sclerosis Journal, Год журнала: 2024, Номер unknown
Опубликована: Сен. 9, 2024
Infection by cytomegalovirus (HCMV) and Epstein-Barr virus (EBV) play a prognostic role in multiple sclerosis (MS).
Язык: Английский
Процитировано
1
medRxiv (Cold Spring Harbor Laboratory), Год журнала: 2023, Номер unknown
Опубликована: Апрель 20, 2023
The UK Biobank (UKB) imaging project is a crucial resource for biomedical research, but limited to 100,000 participants due cost and accessibility barriers. Here we used genetic data predict heritable imaging-derived phenotypes (IDPs) larger cohort. We developed evaluated 4,375 IDP scores (IGS) derived from UKB brain body images. When applied who were not imaged, IGS revealed links numerous stratified at increased risk both somatic diseases. For example, identified individuals higher Alzheimer's disease multiple sclerosis, offering additional insights beyond traditional polygenic of these independent external cohorts, also those high in the All Us Research Program Disease Neuroimaging Initiative study. Our results demonstrate that, while cohort largely healthy may be most enriched management, it holds immense potential stratifying various diseases broader cohorts.
Язык: Английский
Процитировано
2
Multiple Sclerosis Journal, Год журнала: 2024, Номер 30(4-5), С. 585 - 593
Опубликована: Фев. 15, 2024
Background: Despite advancements in treatments of multiple sclerosis (MS), there is a lack awareness early MS symptoms, especially students and the public, contributing to delays diagnosis treatment. This review aims identify gaps tools increase provide bilingual framework facilitate recognition symptoms. Methods: We performed literature determine use English Spanish mnemonics education for medical patients. Results: There no educational tool help remember signs at present. Here we present encompassed VISIBLY (English) VISIBLE (Spanish). stands (1) Vision changes: Painful vision loss, loss color or double vision; (2) Belly Back numbness Balance issues; (3) Limb weakness Numbness; (4), Young people. version included manuscript. Conclusion: posit that VISIBL-MS provides addresses interconnection between language, culture, health literacy, outcomes can be useful tackle effects literacy on diverse communities.
Язык: Английский
Процитировано
0
Fortschritte der Neurologie · Psychiatrie, Год журнала: 2024, Номер 92(11), С. 468 - 481
Опубликована: Ноя. 1, 2024
Biomarker gelten als Schlüsselelement für die Umsetzung von Präzisionsmedizin. Technische Fortschritte in der Quantifizierbarkeit ZNS-Molekülen im peripheren Blut und Design klinischen Studien zur Identifizierung Validierung Biomarkern haben den letzten Jahren zu einer starken Dynamik Biomarkerentwicklung sowohl bei entzündlichen auch degenerativen Erkrankungen des Nervensystems geführt. Die vorliegende Übersicht fasst aktuellen Stand Entwicklungslinien molekularen neurologischen zusammen.
Процитировано
0
European Radiology, Год журнала: 2024, Номер unknown
Опубликована: Ноя. 15, 2024
Язык: Английский
Процитировано
0
Frontiers in Neurology, Год журнала: 2024, Номер 15
Опубликована: Фев. 15, 2024
Background Patient disability, relapse rate, and age are used for family planning in multiple sclerosis (MS). However, the need more accurate biomarkers is widely recognized. We aimed to explore influence of on neurofilament light chain (sNfL), which reflects acute inflammation; glial fibrillary acidic protein (GFAP), associated with disability progression independent relapses; anti-Müllerian hormone (AMH), reflecting ovarian reserve, provide a tailored strategy. Methods This case-control study included 95 MS patients 61 healthy control women (HCW). sNfL GFAP levels were measured using sensitive single-molecule array assay. AMH by automated Elecsys ® Anti-Müllerian Hormone Assay. Results observed no significant differences values between group within any age-matched categories. Age exhibited negative correlation both groups, as expected. Nevertheless, our findings suggest slight tendency toward reduced reserve (rho = −0.67, p < 0.0001; rho HCW −0.43, 0.0006). Interestingly, among 76 participants under 40 years old, we identified ten individuals (13.1%) below 0.7 ng/ml, indicative low an additional six (7.8%) ng/ml 0.9 suggesting potential risk premature failure. Conversely, high variability but showed association intervals. Conclusion found AMH, or The assessment sNFL at onset facilitates personalized therapeutic strategies childbearing-age women.
Язык: Английский
Процитировано
0
Elsevier eBooks, Год журнала: 2024, Номер unknown, С. 35 - 86
Опубликована: Янв. 1, 2024
Язык: Английский
Процитировано
0
Journal of Neuroimaging, Год журнала: 2024, Номер 34(5), С. 497 - 504
Опубликована: Авг. 22, 2024
Abstract Background and Purpose Magnetic resonance imaging (MRI) is heavily relied upon for the diagnosis monitoring of multiple sclerosis (MS), a chronic, demyelinating disease central nervous system. Serum biomarkers may serve as an accessible tool increasing sensitivity, improving accessibility, corroborating symptoms, providing additional data to guide clinical management. This scoping review investigates current understanding how serum biomarker glial fibrillary acidic protein (sGFAP) relates brain MRI metrics. Methods We adhered Joanna Briggs Institute methodology reviews Preferred Reporting Items Systematic Meta‐Analyses guidelines. The databases Medline (Ovid), Embase CINAHL (Ebsco), Web Science (University British Columbia institutional access) were searched on August 24, 2023 using combination medical subject headings keyword terms topic in MS. Results A total 9880 articles retrieved which 6271 unique titles abstracts screened. Twelve 259 resultant papers contained sGFAP proceeded extraction. It was found that lesion metrics generally had positive relationship with sGFAP, while gray matter white metrics, including normal‐appearing matter, related negatively or not at all. Conclusions These results highlight be specific MS, it have utility sensitivity postdiagnosis MS progression.
Язык: Английский
Процитировано
0
Med, Год журнала: 2024, Номер unknown
Опубликована: Окт. 1, 2024
Язык: Английский
Процитировано
0